Functional immune characterization of HIV-associated non-small-cell lung cancer.

Dear Editor, In the combined anti-retroviral therapy (cART) era, non-small cell lung cancer (NSCLC) is a highly incident cause of morbidity and mortality in people living with HIV (PLHIV)[1]. The immune-pathogenesis of NSCLC and HIV infection both rely on programmed-death 1 (PD-1) receptor-ligand interaction as a mechanism to induce T-cell exhaustion. To date, PLHIV have been excluded from clinical trials of immune-checkpoint inhibitors (ICPI), on the presumption that anti-tumour immunity might be compromised by HIV infection. To verify this, we evaluated the clinico-pathologic significance of PD-ligands expression in a consecutive series of 221 archival NSCLC samples, 24 of which were HIV-associated (Table S1)

A proposed methodology for the calculation of direct consumption of fossil fuels and electricity for livestock breeding, and its application to Cyprus

On-farm energy consumption is becoming increasingly important in the context of rising energy costs and concerns over greenhouse gas emissions. For farmers throughout the world, energy inputs represent a major and rapidly increasing cost. In many countries such as Cyprus, however, there is lack of systematic research on energy use in agriculture, which hinders benchmarking end evaluation of approaches and investment decisions for energy improvement. This study established a methodology for the estimation of the direct consumption of fossil fuels and electricity for livestock breeding, excluding transport, for locations where full data sets are not available. This methodology was then used to estimate fossil fuel and electricity consumption for livestock breeding in Cyprus. For 2008, this energy was found to be equivalent to 40.3 GWh that corresponds to 8% of the energy used in agriculture. Differences between the energy consumption per animal in Cyprus and other countries was found to be mainly due to differences in climatic conditions and technologies used in the farm

A review of simple to scientific models for anaerobic digestion

To fully model the anaerobic digestion process, biological and physico-chemical background, the kinetics of bacterial growth, substrate degradation and product formation have to be taken into account. The presented approaches differ depending on the requirements and the developer of the model. Important parameters affecting the process such as temperature, which can cause great inaccuracy, are rarely included in the models. Simple calculators are also available that estimate the applicability of the process to a specific farm and provide information to a farmer or a decision maker. Six simple calculators are presented in this study: AD decision support software, Anaerobic Digestion Economic Assessment Tool, BEAT2, BioGC, FarmWare and GasTheo. The simpler calculators mainly use the relation that exists between volatile solids and biogas production. A tested case of 100 dairy cows and 50 sows was applied to the simple calculators to compare the results

Energy production from piggery waste using anaerobic digestion: Current status and potential in Cyprus

In this work the current status and the potential of biogas production and energy generation through the anaerobic digestion of piggery waste in Cyprus are presented. The onsite use of anaerobic digestion for treating piggery waste not only generates renewable energy, but it is also a sustainable waste management solution. The actual values of the biogas production (20,475m3/day) and the energy generation are compared with the theoretical values, which are in line with several units. The value 20m3/tonne of pig waste was found to predict more accurately the biogas, heat and electricity production compared to the value of 36m3/tonne of pig waste. Moreover, an empirical equation (R2=0.9939) is proposed for calculating the biogas production per day, according to the volume of pig waste treated per day BGP=14.64 (PWT)+535. The potential biogas production from the total pig population of Cyprus equals to 29,734,356m3/yr and the potential thermal and electrical energy are calculated to be 90.85GWhth/yr and 63.59GWhel/yr, respectively. Finally future alternatives on anaerobic digestion in Cyprus are presented such as co-digestion, centralized anaerobic digestion, hydrothermal pre-treatment, possible use of fuel cells and efficient utilization of pig slurry

Is transoral robotic surgery a safe and effective multilevel treatment for obstructive sleep apnoea in obese patients following failure of conventional treatment(s)?

A best evidence topic was written according to a structured protocol. The question addressed was whether TransOral Robotic Surgery (TORS) is a safe and effective multilevel treatment for Obstructive Sleep Apnoea (OSA) in obese patients following failure of conventional treatment(s). A total of 39 papers were identi fi ed using the reported searches of which 5 represented the best evidence to answer the clinical question. The authors, date, journal, study type, population, main outcome measures and results are tabulated. Existing treatments for OSA - primarily CPAP - though highly effective are poorly tolerated resulting in an adherence often lower than 50%. As such, surgery is regaining momentum, especially in those patients failing non-surgical treatment (CPAP or oral appliances). TORS represents the latest addition to the armamentarium of Otorhinolaryngologists - Head and Neck Surgeons for the manage- ment of OSA. The superior visualisation and ergonomics render TORS ideal for the multilevel treatment of OSA. However, not all patients are suitable candidates for TORS and its suitability is questionable in obese patients. In view of the global obesity pandemic, this is an important question that requires addressing promptly. Despite the drop in success rates with increasing BMI, the success rate of TORS in non-morbidly obese patients (BMI ¼ 30-35kgm -2 ) exceeds 50%. A 50% success rate may at fi rst seem low, but it is important to realize that this is a patient cohort suffering from a life-threatening disease and no option left other than a tracheostomy. As such, TORS represents an important treatment in non-morbidly obese OSA patients following failure of conventional treatment(s