Intra-amniotic Infection Caused by Capnocytophaga Species

Background: Capnocytophaga species are common oral pathogens and infrequent causes of systemic infection in patients with compromised host. The isolation of this organism suggests an oral source of infection

AGN X-ray irradiation of CO gas in NGC 2110 revealed by ChandraChandra and ALMA

We report spatial distributions of the Fe-K$\alpha$ line at 6.4 keV and the CO($J$ = 2--1) line at 230.538 GHz in NGC 2110, which are respectively revealed by $Chandra$ and ALMA at $\approx$ 0.5 arcsec. A $Chandra$ 6.2--6.5 keV-to-3.0--6.0 keV image suggests that the Fe-K$\alpha$ emission extends preferentially in a northwest-to-southeast direction out to $\sim$ 3 arcsec, or 500 pc, on each side. Spatially-resolved spectral analyses support this by finding significant Fe-K$\alpha$ emission lines only in northwest and southeast regions. Moreover, their equivalent widths are found $\sim$ 1.5 keV, indicative for the fluorescence by nuclear X-ray irradiation as the physical origin. By contrast, CO($J$ = 2--1) emission is weak therein. For quantitative discussion, we derive ionization parameters by following an X-ray dominated region (XDR) model. We then find them high enough to interpret the weakness as the result of X-ray dissociation of CO and/or H$_2$. Another possibility also remains that CO molecules follow a super-thermal distribution, resulting in brighter emission in higher-$J$ lines. Further follow-up observations are encouraged to draw a conclusion on what predominantly changes the inter-stellar matter properties, and whether the X-ray irradiation eventually affects the surrounding star formation as an AGN feedback.Comment: 15 pages, 11 figures, 3 tables. Accepted for publication in Ap

ALMA 0.02"-resolution observations reveal HCN-abundance-enhanced counter-rotating and outflowing dense molecular gas at the NGC 1068 nucleus

We present ALMA ~0.02"-resolution observations of the nucleus of the nearby (~14 Mpc) type-2 AGN NGC 1068 at HCN/HCO+/HNC J=3-2 lines, as well as at their 13C isotopologue and vibrationally excited lines, to scrutinize the morphological/dynamical/chemical/physical properties of dense molecular gas in the putative dusty molecular torus around a mass-accreting supermassive black hole. We confirm almost east-west-oriented dense molecular gas emission both morphologically and dynamically, which we regard as coming from the torus. Bright emission is compact (<3 pc), and low-surface-brightness emission extends out to 5-7 pc. These dense molecular gas properties are not symmetric between the eastern and western torus. The HCN J=3-2 emission is stronger than the HCO+ J=3-2 emission within the ~7 pc torus region, with an estimated dense molecular mass of (0.4-1.0)x10^6Msun. We interpret that HCN abundance is enhanced in the torus. We detect signatures of outflowing dense molecular gas and a vibrationally excited HCN J=3-2 line. Finally, we find that in the innermost (<1 pc) part of the torus, the dense molecular line rotation velocity, relative to the systemic velocity, is the opposite of that in the outer (>2 pc) part, in both the eastern and western torus. We prefer a scenario of counter-rotating dense molecular gas with innermost almost-Keplerian-rotation and outer slowly rotating (far below Keplerian) components. Our high-spatial-resolution dense molecular line data reveal that torus properties of NGC 1068 are much more complicated than the simple axi-symmetrically rotating torus picture in the classical AGN unification paradigm.Comment: 45 pages, 20 Figures. Accepted for publication in Ap

パンティストッキングのサイズに関する一考察

On this study, usefulness of new various sizes in girth of panty hoses was examined with wearing test of panty hoses (of new size and present size) and measurement of body size. The reserch about consciousness for panty hoses (for example, the price, the way of buying, and so on) was also carried out to women who have been wearing the panty hoses in daily life. The results were summarized as follows. 1. New vafious sizes in circumference of panty hoses is prefered to present size of them, and usefullness of new size is proved. 2. It is recognized that the discontent with the length of panty hoses is still remaind under the new size products. Therefore, the development of various sizes toward the length of panty hoses is desired. 3. The good fitness is precious factor for the consumer next to the price and color. 4. It is important that the information and knowledge of the size of panty hoses must be diffused for the consumer

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

Designing non-natural antibody formats is a practical method for developing highly functional next-generation antibody drugs, particularly for improving the therapeutic efficacy of cancer treatments. One approach is constructing bispecific antibodies (bsAbs). We previously reported a functional humanized bispecific diabody (bsDb) that targeted epidermal growth factor receptor and CD3 (hEx3-Db). We enhanced its cytotoxicity by constructing an Fc fusion protein and rearranging order of the V domain. In this study, we created an additional functional bsAb, by integrating the molecular formats of bsAb and high-affinity mutants previously isolated by phage display in the form of Fv. Introducing the high-affinity mutations into bsDbs successfully increased their affinities and enhanced their cytotoxicity in vitro and in vivo. However, there were some limitations to affinity maturation of bsDb by integrating high-affinity Fv mutants, particularly in Fc-fused bsDb with intrinsic high affinity, because of their bivalency. The tetramers fractionated from the bsDb mutant exhibited the highest in vitro growth inhibition among the small bsAbs and was comparable to the in vivo anti-tumor effects of Fc-fused bsDbs. This molecule shows cost-efficient bacterial production and high therapeutic potential

軽度要介護認定者の介護サービス未利用と社会関連性との関連

The objective of this study was to understand the state of long-term care service use by individuals certified as requiring lower care and, from the viewpoint of their relationship with society, to clarify why individuals do not use services. A questionnaire using un-named, individually filled-in forms via mailing was administered targeting 2,355 elderly people who maintain an at home lifestyle and receive approved Needing support 1 and 2 and Long-term care 1 and 2. We have received the following results. ① Participants not using had higher IADL scores. Also, the group who need support showed a significantly higher rate in living alone, and the group who need long-term care had a lower average age and showed a significantly higher rate in residency of 10 years or more. ② The group who need support responded, “Having discussion with family members” while the group who need longterm care responded, “no discussion with family members and other people.” Thereby, showing a relation to unused long-term care service. From the above results, we have determined that the group who need support and the group who need long-term care have different backgrounds, revealing the possibility that the groups require separate support measures. Moreover, there is a possibility that those not using but belonging to the group who need long-term care may be isolated from family and neighbors. Hence it may be required to create a mechanism in which we can gain an understanding of their situation and build an individual relationship with them through house-calls, etc

トクシマ ダイガク ビョウイン ノウソッチュウ センター ニオケル インナイ ハッショウ ノウソッチュウ ノ ケントウ

We assessed the current status of patients with acute in-hospital stroke. 63 patients with acute in-hospital stroke were enrolled. The most prevalent subtype of stroke was embolism（n＝24）. The main cause of hospitalization were malignant neoplasms in15. Only 5 patients were treated with rt-PA, 8 patients received endovascular interventions. In-hospital stroke is a sever complication of in-patients and is associated with an unfavorable prognosis, but endovascular interventions offer safe and feasible therapeutic treatment options