15,110 research outputs found
Potential for Higgs Physics at the LHC and Super-LHC
The expected sensitivity of the LHC experiments to the discovery of the Higgs
boson and the measurement of its properties is presented in the context of both
the standard model and the its minimal supersymmetric extension. Prospects for
a luminosity-upgraded ``Super-LHC'' are also presented.Comment: Invited talk at 2005 International Linear Collider Physics and
Detector Workshop and Second ILC Accelerator Workshop, Snowmass,
CO(Snowmass05) 3 pages, 0 figures. PSN ALCPG060
Multivariate Analysis from a Statistical Point of View
Multivariate Analysis is an increasingly common tool in experimental high
energy physics; however, many of the common approaches were borrowed from other
fields. We clarify what the goal of a multivariate algorithm should be for the
search for a new particle and compare different approaches. We also translate
the Neyman-Pearson theory into the language of statistical learning theory.Comment: Talk from PhyStat2003, Stanford, Ca, USA, September 2003, 4 pages,
LaTeX, 1 eps figures. PSN WEJT00
Frequentist Hypothesis Testing with Background Uncertainty
We consider the standard Neyman-Pearson hypothesis test of a
signal-plus-background hypothesis and background-only hypothesis in the
presence of uncertainty on the background-only prediction. Surprisingly, this
problem has not been addressed in the recent conferences on statistical
techniques in high-energy physics -- although the its confidence-interval
equivalent has been. We discuss the issues of power, similar tests, coverage,
and ordering rules. The method presented is compared to the Cousins-Highland
technique, the ratio of Poisson means, and ``profile'' method.Comment: Talk from PhyStat2003, Stanford, Ca, USA, September 2003, 4 pages,
LaTeX, 2 eps figures. PSN WEMT00
Transmission eigenvalues and thermoacoustic tomography
The spectrum of the interior transmission problem is related to the unique
determination of the acoustic properties of a body in thermoacoustic imaging.
Under a non-trapping hypothesis, we show that sparsity of the interior
transmission spectrum implies a range separation condition for the
thermoacoustic operator. In odd dimension greater than or equal to three, we
prove that the transmission spectrum for a pair of radially symmetric
non-trapping sound speeds is countable, and conclude that the ranges of the
associated thermoacoustic maps have only trivial intersection
Genome Sequence of Kurthia Type Species Kurthia zopfii Strain ATCC 33403T
The genome of the type strain of the Kurthia genus, Kurthia zopfii ATCC 33403, was sequenced. Nonpathogenic K. zopfii has been isolated from intestinal contents, fecal material, meats, meat products, milk, water, and air, including air at high altitudes. The predicted genome size is 2,878,279 bp, with 37.05% G+C content
Treating hepatic steatosis and fibrosis by modulating mitochondrial pyruvate metabolism
A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease (NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and diabetes. The spectrum of NAFLD ranges from simple hepatic fat accumulation to a more severe disease termed nonalcoholic steatohepatitis (NASH), involving inflammation, hepatocyte death, and fibrosis. Importantly, NASH is linked to a much higher risk of cirrhosis, liver failure, and hepatocellular carcinoma, as well as an increased risk for nonhepatic malignancies and cardiovascular disease. Interest in the understanding of the disease processes and search for treatments for the spectrum of NAFLD-NASH has increased exponentially, but there are no approved pharmacologic therapies. In this review, we discuss the existing literature supporting insulin-sensitizing thiazolidinedione compounds as potential drug candidates for the treatment of NASH. In addition, we put these results into new context by summarizing recent studies suggesting these compounds alter mitochondrial metabolism by binding and inhibiting the mitochondrial pyruvate carrier. Keywords: Nonalcoholic Steatohepatitis, Mitochondria, Pyruvate, Thiazolidinedion
Complete Genome Sequence of Staphylococcus epidermidis ATCC 12228 Chromosome and Plasmids Generated by Long-Read Sequencing
Staphylococcus epidermidis ATCC 12228 was sequenced using a long-read method to generate a complete genome sequence, including some plasmid sequences. Some differences from the previously generated short-read sequence of this nonpathogenic and non-biofilm-forming strain were noted. The assembly size was 2,570,371 bp with a total G+C% content of 32.08%
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