High-power 1.3 µm superluminescent diode

Superluminescent diodes with high output power (10 mW at 175 mA), wide spectral width (28 nm), low spectral modulation depth (<15%), wide frequency modulation bandwidth (570 MHz), and high single-mode fiber coupling efficiency (40%) are reported. The structure is based on a buried crescent laser structure with an antireflection coating and a "short-circuit" absorber to suppress lasing

Long time Solutions for a Burgers-Hilbert Equation via a Modified Energy Method

We consider an initial value problem for a quadratically nonlinear inviscid Burgers-Hilbert equation that models the motion of vorticity discontinuities. We use a modified energy method to prove the existence of small, smooth solutions over cubically nonlinear time-scales

The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease

Alcoholic liver disease (ALD) is one of the most common liver diseases worldwide characterized by the accumulation of lipids within the liver, inflammation and the possibility of progressing to cirrhosis and liver failure. More importantly, there are currently no effective treatments for ALD and liver transplantation remains the only therapeutic option for end-stage liver disease. Previous studies have shown that ALD is a result of a combination of endoplasmic reticulum (ER) stress, lipid metabolism dysregulation and inflammation. It has been previously reported that alcohol disrupts gut microbiota homeostasis and causes increased endotoxins that contribute to the pathology of ALD. However, the detailed mechanism(s) underlying ALD and disease progression is poorly understood. We have discovered that sphingosine kinase 2 (SphK2) deficient (SphK2-/-) mice on an alcohol diet exhibit increased steatosis and inflammation compared to wild type mice. Sphingosine 1-phosphate receptor 2 (S1PR2) and SphK2 have been previously shown to play a key role in nutrient metabolism and signaling. However, their roles in alcohol-induced liver injury have not been characterized. The overall objective of this study is to determine the molecular mechanism(s) by which disruption of S1PR2-mediated SphK2 signaling contributes to ALD. The effects of alcohol on mouse primary hepatocytes and cultured RAW264.7 macrophages were examined. The acute on chronic alcohol mouse model from NIAAA that recapitulates the drinking pattern of human ALD patients was used to study the effects of SphK2 deficiency in ALD. In addition, 60-day chronic alcohol mouse model was used to determine whether a more severe form of ALD was present in SphK2-/- mice. The results indicated that SphK2-/- mice on an alcohol diet exhibited an increased amount of hepatic steatosis compared to wild type mice. Genes regulating lipid metabolism were also dysregulated in SphK2-/- mice. SphK2-/- mice also had increased inflammation and liver injury as shown by an upregulation of inflammatory markers and increased levels of liver enzymes. Moreover, SphK2 protein expression levels were downregulated in the human livers of alcoholic cirrhotic and hepatocellular carcinoma (HCC) patients. These findings contribute to a greater understanding of the pathophysiology of ALD and could provide information on the development of novel therapeutics against ALD

Unconditionally secure key distillation from multi-photons

In this paper, we prove that the unconditionally secure key can be surprisingly extracted from {\it multi}-photon emission part in the photon polarization-based QKD. One example is shown by explicitly proving that one can indeed generate an unconditionally secure key from Alice's two-photon emission part in ``Quantum cryptography protocols robust against photon number splitting attacks for weak laser pulses implementations'' proposed by V. Scarani {\it et al.,} in Phys. Rev. Lett. {\bf 92}, 057901 (2004), which is called SARG04. This protocol uses the same four states as in BB84 and differs only in the classical post-processing protocol. It is, thus, interesting to see how the classical post-processing of quantum key distribution might qualitatively change its security. We also show that one can generate an unconditionally secure key from the single to the four-photon part in a generalized SARG04 that uses six states. Finally, we also compare the bit error rate threshold of these protocols with the one in BB84 and the original six-state protocol assuming a depolarizing channel.Comment: The title has changed again. We considerably improved our presentation, and furthermore we proposed & analyzed a security of a modified SARG04 protocol, which uses six state

What could be learnt from Positronium for Quarkonium?

In order to fulfill Low's theorem requirements, a new lowest order basis for bound state decay computations is proposed, in which the binding energy is treated non-perturbatively. The properties of the method are sketched by reviewing standard positronium decay processes. Then, it is shown how applying the method to quarkonia sheds new light on some longstanding puzzles.Comment: 12 pages, 10 figures. Talk given at the ETH Workshop on Positronium Physics, May 30-31, 2003, Zurich, Switzerlan

Comparative lipid profiling dataset of the inflammation-induced optic nerve regeneration.

In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RGCs die after acute injury and in progressive degenerative diseases such as glaucoma; this can lead to permanent vision loss and, eventually, blindness. Lipids are crucial for the development and maintenance of cell membranes, myelin sheaths, and cellular signaling pathways, however, little is known about their role in axon injury and repair. Studies examining changes to the lipidome during optic nerve (ON) regeneration could greatly inform treatment strategies, yet these are largely lacking. Experimental animal models of ON regeneration have facilitated the exploration of the molecular determinants that affect RGC axon regeneration. Here, we analyzed lipid profiles of the ON and retina in an ON crush rat model using liquid chromatography-mass spectrometry. Furthermore, we investigated lipidome changes after ON crush followed by intravitreal treatment with Zymosan, a yeast cell wall derivative known to enhance RGC regeneration. This data is available at the NIH Common Fund's Metabolomics Data Repository and Coordinating Center (supported by NIH grant, U01-DK097430) website, the Metabolomics Workbench, http://www.metabolomicsworkbench.org, where it has been assigned Project ID: PR000661. The data can be accessed directly via it's Project DOI: doi: 10.21,228/M87D53

Neuroprotection and acidosis induced by cortical spreading depression

We read with interest the article “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5” published in Neuropsychiatr Dis Treat by Viggiano et al.1 The authors showed that cerebral spreading depression (CSD) triggered uncoupling protein-5 (UCP-5),1 which had been reported to exert a long-term effect upon neuron protection.2 The result is another piece in CSD literature on modifying gene expressions to provide neuroprotection to subsequent ischemic episodes.3,

On the performance of two protocols: SARG04 and BB84

We compare the performance of BB84 and SARG04, the later of which was proposed by V. Scarani et al., in Phys. Rev. Lett. 92, 057901 (2004). Specifically, in this paper, we investigate SARG04 with two-way classical communications and SARG04 with decoy states. In the first part of the paper, we show that SARG04 with two-way communications can tolerate a higher bit error rate (19.4% for a one-photon source and 6.56% for a two-photon source) than SARG04 with one-way communications (10.95% for a one-photon source and 2.71% for a two-photon source). Also, the upper bounds on the bit error rate for SARG04 with two-way communications are computed in a closed form by considering an individual attack based on a general measurement. In the second part of the paper, we propose employing the idea of decoy states in SARG04 to obtain unconditional security even when realistic devices are used. We compare the performance of SARG04 with decoy states and BB84 with decoy states. We find that the optimal mean-photon number for SARG04 is higher than that of BB84 when the bit error rate is small. Also, we observe that SARG04 does not achieve a longer secure distance and a higher key generation rate than BB84, assuming a typical experimental parameter set.Comment: 48 pages, 10 figures, 1 column, changed Figs. 7 and