Sex and Gender-Based Women\u27s Health: A Practical Guide for Primary Care - A Resource for Learning and Teaching

TOP WINNER Background: Patients expect comprehensive, gender-specific care; yet studies reveal that few residency programs in internal medicine provide dedicated training in women’s health and gender-based medicine. Further, graduates are unable to demonstrate competency to care for female and gender-diverse patients. Objectives: To produce a sex and gender-based women’s health curriculum, written explicitly for primary care providers to guide the care of women and gender-diverse patients, and to be used as a curriculum to educate learners. Methods: In collaboration with Springer Nature, development of this online and inprint textbook began in 2017. Topics were chosen with input from women’s health experts and are tailored to gender-based conditions commonly evaluated, diagnosed, and/or managed in the primary care setting. Authors were then recruited nationally for each topic. Using evidenced-based medicine principles, chapters were formatted for consistency to include the epidemiology, physiology/pathophysiology, clinical manifestations, differential diagnosis, diagnostic approach, and treatment for each topic, when appropriate. Each chapter has clear, measurable learning objectives, summary statements, and multiplechoice questions with annotated answers to check understanding and help earn CME and MOC credit. With 39 chapters and \u3e600 pages, sections are comprehensive and include Breast and Gynecologic Health and Disease, Obstetric Medicine, Chronic Pain Disorders, Mental Health and Trauma, LGBTQ Health, Common Medical Conditions (osteoporosis, cardiovascular disease), and Foundations of Women’s Health, which highlights the history, disparities, and future of women’s and gender-based healthcare. Conclusions/Impact: This is the first comprehensive curricular resource written by clinical women’s health physicians, using the most up-to-date evidence, clinical guidelines, expert opinion, and clinical pearls. Our goal is to provide a guide that can serve as a quick point-of-care clinical reference for a specific topic or as a longitudinal curriculum for learners in any primary care discipline, especially programs where women’s health and gender-specific curricula and champions are sparse.https://jdc.jefferson.edu/sexandgenderhealth/1030/thumbnail.jp

Benchmark RGB-D Gait Datasets: A Systematic Review

Human motion analysis has proven to be a great source of information for a wide range of applications. Several approaches for a detailed and accurate motion analysis have been proposed in the literature, as well as an almost proportional number of dedicated datasets. The relatively recent arrival of depth sensors contributed to an increasing interest in this research area and also to the emergence of a new type of motion datasets. This work focuses on a systematic review of publicly available depth-based datasets, encompassing human gait data which is used for person recognition and/or classification purposes. We have conducted this systematic review using the Scopus database. The herein presented survey, which to the best of our knowledge is the first one dedicated to this type of datasets, is intended to inform and aid researchers on the selection of the most suitable datasets to develop, test and compare their algorithms. (c) Springer Nature Switzerland AG 2019

Garotas de loja, história social e teoria social [Shop Girls, Social History and Social Theory]

Shop workers, most of them women, have made up a significant proportion of Britain’s labour force since the 1850s but we still know relatively little about their history. This article argues that there has been a systematic neglect of one of the largest sectors of female employment by historians and investigates why this might be. It suggests that this neglect is connected to framings of work that have overlooked the service sector as a whole as well as to a continuing unease with the consumer society’s transformation of social life. One element of that transformation was the rise of new forms of aesthetic, emotional and sexualised labour. Certain kinds of ‘shop girls’ embodied these in spectacular fashion. As a result, they became enduring icons of mass consumption, simultaneously dismissed as passive cultural dupes or punished as powerful agents of cultural destruction. This article interweaves the social history of everyday shop workers with shifting representations of the ‘shop girl’, from Victorian music hall parodies, through modernist social theory, to the bizarre bombing of the Biba boutique in London by the Angry Brigade on May Day 1971. It concludes that progressive historians have much to gain by reclaiming these workers and the service economy that they helped create

Modulation of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase activity and oxidative modification during the development of adjuvant arthritis

Adjuvant arthritis (AA) was induced by intradermal administration of Mycobacterium butyricum to the tail of Lewis rats. In sarcoplasmic reticulum (SR) of skeletal muscles, we investigated the development of AA. SR Ca2+-ATPase (SERCA) activity decreased on day 21, suggesting possible conformational changes in the transmembrane part of the enzyme, especially at the site of the calcium binding transmembrane part. These events were associated with an increased level of protein carbonyls, a decrease in cysteine SH groups, and alterations in SR membrane fluidity. There was no alteration in the nucleotide binding site at any time point of AA, as detected by a FITC fluorescence marker. Some changes observed on day 21 appeared to be reversible, as indicated by SERCA activity, cysteine SH groups, SR membrane fluidity, protein carbonyl content and fluorescence of an NCD-4 marker specific for the calcium binding site. The reversibility may represent adaptive mechanisms of AA, induced by higher relative expression of SERCA, oxidation of cysteine, nitration of tyrosine and presence of acidic phospholipids such as phosphatidic acid. Nitric oxide may regulate cytoplasmic Ca2+ level through conformational alterations of SERCA, and decreasing levels of calsequestrin in SR may also play regulatory role in SERCA activity and expression