1 research outputs found
Regioselective Direct C‑3 Arylation of Imidazo[1,2‑<i>a</i>]pyridines with Aryl Tosylates and Mesylates Promoted by Palladium–Phosphine Complexes
Direct C-3 arylation
of imidazoÂ[1,2-<i>a</i>]Âpyridines
with aryl tosylates and mesylates has been accomplished by employing
palladiumÂ(II) acetate associated with SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl)
or <b>L1</b> (2-(2-(diisoÂpropylÂphosÂphino)Âphenyl)-1-methyl-1<i>H</i>-indole). This catalyst system can be applied to a wide
range of aryl sulfonates and shows excellent C-3 regioselectivity
of imidazoÂ[1,2-<i>a</i>]Âpyridine. These results represent
the first examples of using tosylate- and mesylate-functionalized
arenes as the electrophile partners for this regioselective direct
arylation