Myomectomy in pregnant patient with multiplace uterine myoma

Tactics of managment of reproductive age patients with multplace uterine myoma is disscusable. In spite of high risk of surgical complications the choise of operation treatment, saving of uterus has its own allies. One of the main reason of myomectomy in pregnant patient with uterine myoma is clinical evidence of its necrosis. The case of managment of pregnant woman with multplace uterine mioma is presented in the article.Тактика ведения пациенток репродуктивного возраста с множественной миомой матки является дискутабельной. Решение вопроса о проведении органосохраняющей операции при множественной миоме матки имеет своих сторонников несмотря на высокий риск осложнений при удалении множества миоматозных узлов. Одним из показаний для оперативного лечения миомы матки при беременности является нарушение питания или некроз опухоли. Приведено описание случая собственного ведения беременной с множественной миомой с некрозом

COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE

Aim. To compare effects of 12-month monotherapy with nebivolol, enalapril and indapamide on blood pressure (BP), left ventricular hypertrophy and quality of life in the locomotive engineers and their assistants with stress-associated hypertension at the work place (HTwp).Material and methods. 96 locomotive engineers (20- 53 y.o) and their assistants with HTwp were observed. The patients were randomized to receive nebivolol (1 group), enalapril (2 group) or indapamide (3 group). 24-hour BP monitoring, echocardiography and quality of life interview with SF–36 questionnaire were performed at the start and after 12 months of the treatment.Results. Long-term therapy lead to achievement of target BP level, improved quality of life and reduced in left ventricular hypertrophy in patients with HTwp. Nebivolol reduced systolic “BP load” more significantly than indapamide did, exerted favorable influence on circadian BP rhythm and reduced heart rate. Monotherapy with nebivolol showed benefits in effect on quality of life.Conclusion. Nebivolol has some advantages in comparison with indapamide and enalapril in antihypertensive therapy of patients with stress-associated HT

Determination of reference values for TREC and KREC in circulating blood of the persons over 18 years

Increasing attention is being paid to methods for detecting primary and secondary T and/or B cell immunodeficiencies. Their implementation into laboratory diagnostics would contribute to the early diagnostics of immunodeficiencies. Currently, the number of identified adult patients with immunodeficiencies of various origins is steadily increasing. Age, gender and ethnicity of patients may be significant factors of immunity. Hence, determination of the population reference intervals for TREC and KREC DNA excision rings in peripheral blood of adult persons is an urgent laboratory task for in-depth examination of both congenital and acquired immunodeficiency conditions. Our purpose was to determine the reference intervals for the quantitative assay of TREC and KREC fragments in peripheral blood among the adult population of St. Petersburg. We studied whole blood samples obtained from 717 apparently healthy volunteers aged 18 to 108 years within the program of population immunity assessment among residents of St. Petersburg. The exclusion criterion included immunodeficiency of any origin, viral hepatitis A, B, C, HIV infection. Quantitation of the target TREC and KREC DNA fragments was carried out using a set of reagents for the quantitative determination of excisional rings TREC and KREC by Real-time PCR (TREC/KREC-AMP PS). The reference intervals were determined by the direct method according to the recommendations of the International Federation of Clinical Chemistry and the Russian State Standard (GOST) R 53022.3-2008. The volunteers were divided into six age groups: 18-29, 30-39, 40-49, 50-59, 60-69 years old, and the persons over 70. The amounts of TREC and KREC in each blood sample were determined for all age groups. Upon correlation analysis, we have revealed a negative relationship between the concentration of TREC molecules in blood samples, and the age of study participants (Spearman correlation coefficient r = -0.80 (p-value < 0.0001)). Significant differences in TREC levels between different age groups were revealed. No correlations were detected between KREC contents in blood samples and age as well as any differences between age groups. Reference intervals of the TREC level were determined for each mentioned age group. A unified reference range was established for the KREC levels. The established reference intervals for TREC and KREC molecules in adults are significantly lower than in newborns. The obtained results enable determination of reference intervals for TREC and KREC levels among adults, thus contributing to effective personalized laboratory diagnosis of immunodeficiency states of various origins

Clinical speciality of reproductive age women with uterine myoma

In spite of multifactory development reasons of uterine myoma the main method of treatment of reproductive age patients is surgical one. The choise of managment of young women isn't simple, because it's nessesary to make prognosis of growth and character of tumour. Data of reaserch of reproductive age women with uterine myoma are represented in this article. The study group includes 190 patients of the age from 18 to 35 years. The main features are infertility, miscarrige in anamnesis and bad(proliferative) hystological type of myomaНесмотря на мультифакторную природу миомы матки, хирургический метод в комплексном лечении больных репродуктивного возраста является определяющим. Выбор тактики ведения молодых женщин с миомой матки является сложной клинической задачей, решение которой связано с необходимосью прогнозировать темп роста и характер опухоли. Проведено исследование 190 пациенток репродуктивного возраста с миомой матки. Для женщин оптимального ре­продуктивного возраста (от 18 до 35 лет) характерным является наличие бесплодия или невынашивания в анамнезе, отсутствие выраженных симптомов заболевания, пролиферирующий вариант миомы матки

Lambda hyperons produced in central nucleus-nucleus interactions at 4.5 GeV/c momentum per incident nucleon

Transverse momenta and rapidities of Lambda 's produced in central nucleus-nucleus collisions at 4.5 GeV/c·u (C-C,...,O-Pb) were studied and compared with those from inelastic He-Li interactions at the same incident momentum. Polarization of the Lambda hyperons was found to be consistent with zero ( alpha P=-0.06=0.11 for Lambda 's from central collisions). An upper limit of the Lambda -bar / Lambda production ratio was estimated to be less than 4.5 x 10-3. The experiment was performed in a triggered streamer chamber

The requirements for developing the programs and designing a foreign language teaching syllabus for the students following the education internationalization

© 2015 by the authors. Russia’s joining international economic and educational community, expanding multilateral ties with the countries of the united Europe and the United States, the process of internationalization which have affected all major spheres of modern society including education mounts challenges for the design and implementation of the teaching foreign language syllabus. Therefore, this article aims to identify and study the requirements for the development and design of the foreign language teaching syllabus inclusive of the education internationalization compliant with the social order and determined by the linguistic world dynamics, reflecting a vivid communicative, person-oriented and professional focus of teaching a foreign language. The article submissions may be useful to the teachers of “Foreign Language” disciplines as well as for the students of the teachers’ training universities

The requirements for developing the programs and designing a foreign language teaching syllabus for the students following the education internationalization

© 2015 by the authors. Russia’s joining international economic and educational community, expanding multilateral ties with the countries of the united Europe and the United States, the process of internationalization which have affected all major spheres of modern society including education mounts challenges for the design and implementation of the teaching foreign language syllabus. Therefore, this article aims to identify and study the requirements for the development and design of the foreign language teaching syllabus inclusive of the education internationalization compliant with the social order and determined by the linguistic world dynamics, reflecting a vivid communicative, person-oriented and professional focus of teaching a foreign language. The article submissions may be useful to the teachers of “Foreign Language” disciplines as well as for the students of the teachers’ training universities