Realization of a feedback controlled flashing ratchet

A flashing ratchet transports diffusive particles using a time-dependent, asymmetric potential. Particle speed is predicted to increase when a feedback algorithm based on particle positions is used. We have experimentally realized such a feedback ratchet using an optical line trap, and observed that use of feedback increases velocity by up to an order of magnitude. We compare two different feedback algorithms for small particle numbers, and find good agreement with simulations. We also find that existing algorithms can be improved to be more tolerant to feedback delay times

Precipitation Behavior and Magnetic Properties of Cu-Fe-Co Alloys Containing Nanogranular Ferromagnetic-Element Particles

This work investigates the evolution of microstructures and magnetic properties during isothermal annealing of Cu-Fe-Co alloys, using electron microscopy and superconducting quantum interference device (SQUID) magnetometry. Small coherent granular precipitates composed of iron and cobalt formed in the copper matrix in the early stage of precipitation. As annealing proceeded, the precipitates lost coherency to the matrix after reaching a size of 15–20 nm and twin-like structures were consecutively introduced in the particles. The SQUID measurements revealed that the magnetic properties of the specimens correlated with the microstructural evolution. The coercive force initially increased with annealing time but decreased after reaching a peak. Lorentz Microscopy suggested that the initial large increase of magnetization was invoked by a structural transition from fcc to B2 in the precipitates

Analytical calculation of the Peierls-Nabarro pinning barrier for one-dimensional parametric double-well models

Lattice effects on the kink families of two models for one-dimensional nonlinear Klein-Gordon systems with double-well on-site potentials are considered. The analytical expression of the generalized Peierls-Nabarro pinning potential is obtained and confronted with numerical simulations.Comment: RevTex, 10 pages, 4 figure

Improvement in the performance of the X-ray source based on parametric X-ray radiation using a wedge-shaped target crystal

The properties of parametric X-ray radiation (PXR) emitted from a wedge-shaped Si(111) crystal plate were experimentally investigated using the PXR generator at the Laboratory for Electron Beam Research and Application (LEBRA) of Nihon University. The wedge surface was imposed on a symmetric-cut Si(111) plate and has an asymmetric cut-surface with respect to the (111) crystal planes. As a result of the experiment, it was found that the PXR intensity improved can be obtained suppressing the degradation of the X-ray performance using a wedgeshaped target. With this improvement, phase-contrast images without absorption contrast could be obtained from DEI images taken with the exposure of severalten seconds. The reduction of the exposure time made it possible to carry out a computed tomography (CT) experiment by DEI within a practical machine time, and phase-contrast tomograms of a biological sample were obtained at the PXR energy of 17.5 keV

Acoustic Cues for Sound Source Distance and Azimuth in Rabbits, a Racquetball and a Rigid Spherical Model

There are numerous studies measuring the transfer functions representing signal transformation between a source and each ear canal, i.e., the head-related transfer functions (HRTFs), for various species. However, only a handful of these address the effects of sound source distance on HRTFs. This is the first study of HRTFs in the rabbit where the emphasis is on the effects of sound source distance and azimuth on HRTFs. With the rabbit placed in an anechoic chamber, we made acoustic measurements with miniature microphones placed deep in each ear canal to a sound source at different positions (10–160 cm distance, ±150° azimuth). The sound was a logarithmically swept broadband chirp. For comparisons, we also obtained the HRTFs from a racquetball and a computational model for a rigid sphere. We found that (1) the spectral shape of the HRTF in each ear changed with sound source location; (2) interaural level difference (ILD) increased with decreasing distance and with increasing frequency. Furthermore, ILDs can be substantial even at low frequencies when distance is close; and (3) interaural time difference (ITD) decreased with decreasing distance and generally increased with decreasing frequency. The observations in the rabbit were reproduced, in general, by those in the racquetball, albeit greater in magnitude in the rabbit. In the sphere model, the results were partly similar and partly different than those in the racquetball and the rabbit. These findings refute the common notions that ILD is negligible at low frequencies and that ITD is constant across frequency. These misconceptions became evident when distance-dependent changes were examined

Na V 1.6a is required for normal activation of motor circuits normally excited by tactile stimulation

A screen for zebrafish motor mutants identified two noncomplementing alleles of a recessive mutation that were named non-active ( nav mi89 and nav mi130 ). nav embryos displayed diminished spontaneous and touch-evoked escape behaviors during the first 3 days of development. Genetic mapping identified the gene encoding Na V 1.6a ( scn8aa ) as a potential candidate for nav . Subsequent cloning of scn8aa from the two alleles of nav uncovered two missense mutations in Na V 1.6a that eliminated channel activity when assayed heterologously. Furthermore, the injection of RNA encoding wild-type scn8aa rescued the nav mutant phenotype indicating that scn8aa was the causative gene of nav . In-vivo electrophysiological analysis of the touch-evoked escape circuit indicated that voltage-dependent inward current was decreased in mechanosensory neurons in mutants, but they were able to fire action potentials. Furthermore, tactile stimulation of mutants activated some neurons downstream of mechanosensory neurons but failed to activate the swim locomotor circuit in accord with the behavioral response of initial escape contractions but no swimming. Thus, mutant mechanosensory neurons appeared to respond to tactile stimulation but failed to initiate swimming. Interestingly fictive swimming could be initiated pharmacologically suggesting that a swim circuit was present in mutants. These results suggested that Na V 1.6a was required for touch-induced activation of the swim locomotor network. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70:508–522, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75774/1/20791_ftp.pd

Transgenic Zebrafish Recapitulating tbx16 Gene Early Developmental Expression

We describe the creation of a transgenic zebrafish expressing GFP driven by a 7.5 kb promoter region of the tbx16 gene. This promoter segment is sufficient to recapitulate early embryonic expression of endogenous tbx16 in the presomitic mesoderm, the polster and, subsequently, in the hatching gland. Expression of GFP in the transgenic lines later in development diverges to some extent from endogenous tbx16 expression with the serendipitous result that one line expresses GFP specifically in commissural primary ascending (CoPA) interneurons of the developing spinal cord. Using this line we demonstrate that the gene mafba (valentino) is expressed in CoPA interneurons