Physical research of microgravity influence on physical phenomenon in cryogenic liquids and general-purpose onboard cryogenic facility for realization of this researchaboard International Space Station

The united research plan named "Boiling" is created on the basis of several cryogenic research projects developed by experts in Russia and Ukraine for International Space Station. The "Boiling" plan includes 8 first experiments aimed at investigating the influence of microgravity on boiling processes, heat transfer and hydrodynamics in liquid helium being either under normal or superfluid conditions. The experiments are supposed to be carried out with individual cells collected inside a single cryogenic onboard experimental facility. The international research program experiments are characterized by the following features: utilization of several artificially simulated microgravity levels, owing to rotation of the experimental helium cryostat; visualization of the processes that occur in liquid helium; research of boiling and hydrodynamics both in a large volume of stationary liquid, and in a liquid flow running through a channel. Upon completion of the "Boiling" research plan, the cryogenic onboard facility created for International Space Station would be able to find its application in further scientific and experimental researches with helium

Метод расчета объема костнозамещающего материала при операции синус-лифтинга с использованием цифровых технологий

The method of digital planning of sinus-lifting operation using the data of computed tomography, laser surface scanning of dentition, as well as a number of computer programs, the use of which in the treatment of tooth loss allows you to accurately determine the volume of bone-substituting material and the area of implant placement. This technique is based on the digital calculation of the volume of bone-substituting material required for introduction into the maxillary sinus during sinus-lifting operation.Приведен метод цифрового планирования операции синус-лифтинга, используя данные компьютерной томографии, лазерного поверхностного сканирования зубных рядов, а также ряда компьютерных программ, использование которых при лечении потери зубов позволяет точно определять объем костозамещающего материала и зону установки имплантатов. Данная методика основана на цифровом планировании объема костнозамещающего материала, необходимого для внесения в верхнечелюстную пазуху при операции синус-лифтинга

Цифровое планирование как метод профилактики осложнений при операции синус-лифтинга

The method of digital planning of the sinus-lifting operation using data from computed tomography, laser surface scanning of the dentition, as well as a number of computer programs, the use of which in the treatment of tooth loss allows you to accurately position the window for lateral access to the maxillary sinus. This technique is based on digital planning for open sinus-lift surgery.Приведен метод цифрового планирования операции синус-лифтинга с использованием данных компьютерной томографии, лазерного поверхностного сканирования зубных рядов, а также ряда компьютерных программ, использование которых при лечении потери зубов позволяет точно позиционировать костное окно при латеральном доступе в верхнечелюстную пазуху. Данная методика основана на цифровом планировании при операции открытого синус-лифтинга

Bacterial vaginosis: comparative effectiveness of treatments with 5-nitroimidazole derivatives

I.G. Kutsenko, I.O. Borovikov, E.I. Kravtsova, S.K. Batmen, A.S. Magay, O.I. Borovikova, V.A. Avakimyan, A.A. Andreeva Kuban State Medical University, Krasnodar, Russian Federation Aim: to perform a comparative analysis of clinical and microbiological efficacy and compliance to treatment with 5-nitroimidazole derivatives in patients with bacterial vaginosis (BV). Patients and Methods: this prospective open randomized study included 96 patients diagnosed with BV. The patients were divided into two groups: group 1 (n=48) received antimicrobials — oral secnidazole 2000 mg in a single dose (decontamination therapy) and vaginally administered L. casei rhamnosus Doderleini for 14 days to restore the vaginal flora (contamination therapy); group 2 (n=48) received oral metronidazole 500 mg twice daily for 7 days (decontamination therapy) and vaginally administered L. casei rhamnosus Doderleini for 14 days (contamination therapy). Clinical efficacy was evaluated one and six months after the end of therapy. The treatment efficacy criteria included the absence of specific patient's complaints, clinical and laboratory findings (pH; Nugent score), and PCR results. The compliance to treatment was assessed using clinical and psychological tests (the Morisky-Green Scale and the Modified Medication Compliance Scale). The assessment of safety profile was based on the analysis of adverse events (AE). Results: one month after the end of treatment all patients had a statistically significant (p&lt;0.05) reduction in the prevalence of BV symptoms (unpleasant vaginal odor, pathological vaginal discharge, itching, dyspareunia, dysuria events) as compared to those at the baseline. At month 1 after the end of treatment, subgroup analysis did not demonstrate a significant difference. Six months after the end of treatment the proportion of the group 1 patients who had pathological vaginal discharge with specific odor increased to 16.7%, while in the group 2 patients it reduced to 8.3% (p&lt;0.05). Microbiological assessment (PCR) of the combination therapy in two groups of patients with BV demonstrated a high antibacterial efficacy of 5-nitroimidazole derivatives during the first month of follow-up. The patients were considered fully compliant if they scored 4 on the Morisky — Green Scale and scored 30 on the Modified Medication Compliance Scale of V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology. The percentage of full compliance was 76.2±2.8% in the group 1 patients and 93.75±3.25% in the group 2 patients. Conclusion: a high comparative clinical and microbiological effectiveness of treatments with 5-nitroimidazole derivatives (metronidazole and secnidazole) with further vaginal colonization with lactobacilli was demonstrated in patients with bacterial vaginosis. Full medication compliance was higher in patients receiving secnidazole for BV treatment. Keywords: bacterial vaginosis, vaginal microbiota, vaginal discharge, 5-nitroimidazole derivatives, metronidazole, secnidazole, compliance. For citation: Kutsenko I.G., Borovikov I.O., Kravtsova E.I. et al. Bacterial vaginosis: comparative effectiveness of treatments with 5-nitroimidazole derivatives. Russian Journal of Woman and Child Health. 2023;6(2):78–87 (in Russ.). DOI: 10.32364/2618-8430-2023-6-2-78-87. </p

The estimation of the efficiency of the initial orbit determination multistage algorithm at the processing of radar measurements, which are taken within one circle of a low orbit space vehicle

Проведен анализ эффективности многоэтапного алгоритма первоначального определения орбиты космического объекта при обработке результатов измерений нескольких радиолокационных станций на одном витке. По результатам статистического моделирования показаны условия, при которых обеспечивается высокая вероятность взятия на сопровождение низкоорбитального космического объекта на одном мерном витке.Проведений аналіз ефективності багатоетапного алгоритму первинного визначення орбіти космічного об’єкта при обробці результатів вимірювань декількох радіолокаційних станцій на одному витку. За результатами статистичного моделювання показані умови, за яких забезпечується висока імовірність взяття на супроводження низькоорбітального космічного об’єкта на одному мірному витку.The analysis of the efficiency of the initial orbit determination multistage algorithm at processing of some radars’ measurements, which are taken within one circle, is conducted. According to the results of statistical modeling, the conditions, which ensure an achievement of a high probability of taking a low orbit space vehicle on tracking within one measuring circle, are shown

PARITY NON-CONSERVING ASYMMETRY OF LONGITUDINALLY POLARIZED THERMAL NEUTRONS PROPAGATION

L'asymétrie ne conservant pas la parité dans la propagation de neutrons thermiques polarisés longitudinalement a été mesurée pour quelques éléments. Les valeurs suivantes concernant la différence relative des sections efficaces totales pour des neutrons d'hélicités opposées (unités 10-6) ont été obtenues : uranium - 233 : 0,9 ± 0,9, plomb 207 : 0,9 ± 1,7, plomb naturel : 0,0 ± 0,6, thorium - 232 : 0,7 ± 2,3, zirconium naturel : 0,5 ± 0,9, brome naturel : 11,4 ± 1,4.The parity-non-conserving (PNC) asymmetry of the longitudinally polarized thermal neutron propagation was measured for some elements. The following values (in units of 10-6) for the relative difference in total cross-sections for neutrons of opposite helicities have been obtained : uranium - 233 : 0.9 ± 0.9, lead - 207 : 0.9 ± 1.7, natural lead : 0.0 ± 0.6, thorium - 232 : 0.7 ± 2.3, natural zirconium : 0.5 ± 0.9 and natural bromine : 11.4 ± 1.4