Naṣīr al-Dīn al-Ṭūsī’s revision of Theodosius’s Spherics

We examine the Arabic edition of Theodosius’s Spherics composed by Naṣīr al-Dīn al-Ṭūsī. Through a comparison of this text with earlier Arabic and Greek versions and a study of his editorial remarks, we develop a better understanding of al-Ṭūsī editorial project. We show that al-Ṭūsī’s goal was to revitalize the text of Theodosius’s Spherics by considering it firstly as a product of the mathematical sciences and secondarily as a historically contingent work. His editorial practices involved adding a number of additional hypotheses and auxiliary lemmas to demonstrate theorems used in the Spherics, reworking some propositions to clarify the underlying mathematical argument and reorganizing the proof structure in a few propositions. For al-Ṭūsı, the detailed preservation of the words and drawings was less important than a mathematically coherent presentation of the arguments and diagrams

Preference of middle-aged Japanese regarding place to receive end-of-life care: a case study of parents of nursing students

Objectives: This study was performed to assess the preference of middle-aged Japanese regarding end-of-life care. 　Methods: A structured, self-administered questionnaire survey regarding preference of place to receive end-of-life care was performed among parents of nursing school students by postal mail. 　Results: A total of 64 （61.5%） participants returned the questionnaire. Some of the major concerns regarding home-based end-of-life care were being a burden on their family and whether their family would accept care at home at the end of their life. The majority of the participants wanted more information regarding financial support system and availability of medical and care institutions and care support services to receive home-based end-of-life care, regardless of the extent of their pre-existing knowledge regarding end-of-life care, and participants with little or no prior knowledge of the end-of-life care were less likely to appreciate the importance of family support system. 　Conclusions: These results suggest that ignorance about end-of-life care produces a narrower range of choices and limits decision making regarding such care, even though most participants would prefer to receive end-of-life care at home

The Socioeconomic Factors Affecting the Mental Health Status of Family Caregivers of Type 2 Diabetic Patients

As Japan’s ‘super aged society’ develops, more and more aged caregivers are obliged to take care of patients with chronic diseases. In this study, the family caregivers of type 2 diabetic patients were targeted to identify the socioeconomic conditions that affect their mental health status. The results indicated that when the caregivers were overly concerned about the patients’ care, they had higher GHQ （General Health Questionnaire） scores（ r=.685, p<0.05）. On the other hand, the more caregivers spoke frankly about their feelings to the patients, the lower their GHQ Likert Scores were（ r=.-718, p<0.05）. Suggestions for medical staff were made to establish a support system not only for type 2 diabetic patients, but also for the family caregivers of these patients

Safety and Efficacy of FIT039 for Verruca Vulgaris: A Placebo-Controlled, Phase I/II Randomized Controlled Trial

TRIAL DESIGN: Human papillomavirus infection causes verruca vulgaris. CDK9 inhibitor FIT039 inhibits DNA virus proliferation in animal models. We conducted a multicenter, single-blind, placebo-controlled, randomized phase I/II clinical trial evaluating the safety and efficacy of FIT039 against verruca vulgaris. METHODS: Target lesions were treated with liquid nitrogen once, and a FIT039 patch or placebo patch was applied for 14 days. The primary endpoint was lesion disappearance. The secondary endpoints were safety and changes in dimension, cross-sectional area, and the number of petechial lesions. RESULTS: A total of 24 participants were randomly allocated to the FIT039 (n = 13, median age, 54 years) and placebo (n = 11, median age, 62 years) groups. Verruca vulgaris did not disappear. FIT039 decreased the dimension to 76% of the initial value on day 29, followed by an increase to 98% on day 57. Placebo showed a monotonic increase to 107% on day 57. Changes in the cross-sectional area and petechiae number were comparable between the groups. CONCLUSIONS: No drug-related adverse reactions occurred. FIT039 efficacy was not determined in this study

Effects of transcutaneous electrical nerve stimulation on physical symptoms in advanced cancer patients receiving palliative care

Transcutaneous electrical nerve stimulation (TENS) is primarily used for pain, butmight be useful for various other physical symptoms, including nausea, fatigue,dyspnea, and constipation. However, few studies have used TENS for treating thephysical symptoms of patients with advanced cancer. In this crossover trial, we assessthe effects of TENS on pain and other physical symptoms in 20 in-patients withadvanced cancer receiving palliative care. For 5-day phases between wash out periodsof 5 days, patients received TENS or non-TENS. TENS was delivered at four points: thecenter of the back for mainly nausea and dyspnea, on the back at the same dermatomallevel as the origin of the pain (100 Hz), and on both ankle joints for constipation (10Hz). The intensity of pain and the total opioid dose used during phases were recorded.Physical symptoms were evaluated using the European Organization for Research andTreatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care(QLQ-C15-PAL). Hematological and biochemical data were recorded before and afterthe TENS phase. The average pain and total number of opioid rescue doses weresignificantly reduced by TENS. TENS tended to improve nausea and appetite loss, butnot constipation. There were no effects on hematological and biochemical parameters.Use of TENS could safely improve pain, nausea, and appetite loss in patients withadvanced cancer. Although it cannot be used as a substitute for opioids and otherpharmaceutical treatment, it may be useful to support palliative care

マウス乾癬モデルにおいてビタミンD誘導体はIL-17産生能を有するT細胞を抑制する

京都大学0048新制・課程博士博士(医学)甲第22000号医博第4514号新制||医||1038(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 生田 宏一, 教授 竹内 理, 教授 杉田 昌彦学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA