11 research outputs found
High-plasticity mesenchymal stem cells isolated from adult-retained primary teeth and autogenous adult tooth pulp--A potential source for regenerative therapies?
Relation between the catalytic activity of binary compounds of Group II metals with nonmetals and the positions of the elements in Mendeleev's periodic system Communication 4. Catalytic decomposition of isopropyl alcohol over zinc selenide and telluride
The impact of wrong-site surgery on dental undergraduate teaching: a survey of UK dental schools
A M�ssbauer investigation of the structure of modified SA-I catalyst for synthesizing organic compounds from CO and H2O
Surgical treatment of painful inferior alveolar nerve injuries following endodontic treatment: a consecutive case series of seven patients
Inflammatory Cytokines and Biodegradable Scaffolds in Dental Mesenchymal Stem Cells Priming
Mesenchymal stem cells (MSC) are multipotent stem cells with wide-ranging clinical applications due to their ability to regenerate tissue from mesenchymal origin and their capability of suppressing immune responses, thus reducing the likelihood of graft versus host disease after transplantation. MSCs can be isolated from a variety of sources including bone marrow, adipose tissue, umbilical cord blood, and immature teeth. Dental stem cells (DSC) possess progenitor and immunomodulatory abilities as the other MSC types and because they can be easily isolated, are considered as attractive therapeutic agents in regenerative dentistry. Recently, it has been shown that DSCs seeded onto newly developed synthetic biomaterial scaffolds have retained their potential for proliferation and at the same time have enhanced capabilities for differentiation and immunosuppression. The scaffolds are becoming more efficient at MSC priming as researchers learn how short peptide sequences alter the adhesive and proliferative capabilities of the scaffolds by stimulating or inhibiting classical osteogenic pathways. New findings on how to modulate the inflammatory microenvironment, which can prime DSCs for differentiation, combined with the use of next generation scaffolds may significantly improve their therapeutic potential. In this review, we summarize current findings regarding DSCs as a potential regenerative therapy, including stem cell priming with inflammatory cytokines, types of scaffolds currently being explored and the modulation of scaffolds to regulate immune response and promote growth