THE MANAGEMENT OF TUBO-OVARIAN ABSCESS

Objective: To determine the management of tubo-ovarian abscess (TOA) and put out the complications in patients operated on

Sentinel lymph node biopsy in endometrial cancer: description of the technique and preliminary results

Objective: To measure the feasibility of sentinel lymph node technique in endometrial cancer

A CASE OF GASTROINTESTINAL STROMAL TUMOR PRESENTING AS A TUBOOVARIAN ABSCESS

A gastrointestinal stromal tumor (GIST) is a rare tumor of the gastrointestinal tract. Although stomach is the most frequent site of occurrence, GISTs can arise from anywhere in the gastrointestinal tract. The most common symptoms are vague and nonspecific abdominal pain or discomfort. We would like to present a GIST case with the complaint of acute abdominal pain and fever due to an accompanying complex adnexial mass. A 47-year-old female patient with sudden onset abdominal pain and fever applied at our clinic. A 8 cm diameter sized, complex, solid mass on the ultrasonografic examination was found. Her temperature was 38.6 degrees C and on her laboratory examination, leukocyte and CRP values were 27.400 and 254, respectively After an initial diagnosis of tuboovarian abscess, the patient was internalized. Abdominal CT revealed a solid lesion originating from small bowel resulting in signs of sepsis due to a closed perforation. Resection of the mass was performed and the postop pathology report was GIST. Patient had adjuvant imatinib therapy Although GIST's are mostly seen in stomach with vague symptoms, large sized GIST's which occur in the lower abdomen can be complicated and present as having a tuboovarian abscess clinic

Determination of serum CRP, VEGF, Leptin, CK-MB, CA-15-3 and IL-6 levels for malignancy prediction in adnexal masses

Objective: Investigation of serum markers which could be used in the malignancy prediction of adnexal masses

Changes in Markers of Ovarian Reserve After Laparoscopic Ovarian Cystectomy

Study Objective: This study was conducted to determine the changes in ovarian reserve markers after laparoscopic ovarian cystectomy (LOC)

Influence of body mass index on clinicopathologic features, surgical morbidity and outcome in patients with endometrial cancer

To examine the influence of obesity on the patient characteristics and clinicopathologic features of endometrial cancer, and to find how treatment and prognosis were affected by obesity in women with endometrial cancer

Impact of Human Papillomavirus on Wnt/Beta-Catenin Signaling in Morphological Inconspicuous Cervicovaginal Cells

Introduction: The aim of this study was to identify early changes in the Wnt/beta-catenin signaling pathway in high-risk human papillomavirus (HPV) infected cervicovaginal cells and to correlate these changes with cell proliferation, apoptosis, and autophagic processes. Methods: We evaluated 91 cervicovaginal smears of women with (n = 41) and without (n = 50) HPV-DNA. Smears were stained against beta-catenin, c-myc, secreted frizzled-related protein 4 (sFRP4), cleaved caspase-3, and the autophagy markers Beclin-1 and light chain 3B. In addition, sFRP-1, -2, -3, -4, -5 mRNA levels were determined by quantitative reverse transcription-PCR in primary keratinocytes and FaDu cells expressing HPV16-E6, -E7, or -E6E7. Results: Our data indicated that the Wnt/beta-catenin signaling is activated in HPV (+) cervicovaginal cells that can already be detected in cells with no obvious changes in cellular morphology (HPV [+]/cyto [-]). These cells also had significantly higher sFRP4 levels when compared to HPV-negative samples. In primary keratinocytes, sFRP4 was found to be absent and sFRP1 and sFRP2 to be repressed in the presence of HPV16-E6 and E7. Interestingly, sFRP4 is expressed in FaDu cells and can be upregulated in the presence of E6E7. Curiously, SFRP4 expression correlated with an increase in the level of autophagic markers in HPV (+)/cyto (-) smears. Conclusion: In conclusion, the activation of the Wnt/beta-catenin signaling pathway and upregulation of sFRP4, paralleled by an activation of the autophagic pathway may represent predisposing cellular factors early after HPV infection which need to be further determined in larger study

Impact of Human Papillomavirus on Wnt/Beta-Catenin Signaling in Morphological Inconspicuous Cervicovaginal Cells

Introduction: The aim of this study was to identify early changes in the Wnt/beta-catenin signaling pathway in high-risk human papillomavirus (HPV) infected cervicovaginal cells and to correlate these changes with cell proliferation, apoptosis, and autophagic processes. Methods: We evaluated 91 cervicovaginal smears of women with (n = 41) and without (n = 50) HPV-DNA. Smears were stained against beta-catenin, c-myc, secreted frizzled-related protein 4 (sFRP4), cleaved caspase-3, and the autophagy markers Beclin-1 and light chain 3B. In addition, sFRP-1, -2, -3, -4, -5 mRNA levels were determined by quantitative reverse transcription-PCR in primary keratinocytes and FaDu cells expressing HPV16-E6, -E7, or -E6E7. Results: Our data indicated that the Wnt/beta-catenin signaling is activated in HPV (+) cervicovaginal cells that can already be detected in cells with no obvious changes in cellular morphology (HPV [+]/cyto [-]). These cells also had significantly higher sFRP4 levels when compared to HPV-negative samples. In primary keratinocytes, sFRP4 was found to be absent and sFRP1 and sFRP2 to be repressed in the presence of HPV16-E6 and E7. Interestingly, sFRP4 is expressed in FaDu cells and can be upregulated in the presence of E6E7. Curiously, SFRP4 expression correlated with an increase in the level of autophagic markers in HPV (+)/cyto (-) smears. Conclusion: In conclusion, the activation of the Wnt/beta-catenin signaling pathway and upregulation of sFRP4, paralleled by an activation of the autophagic pathway may represent predisposing cellular factors early after HPV infection which need to be further determined in larger study