25 research outputs found
Editorial: Translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma
Multiple organ dysfunction or even failure after sepsis or trauma is due to a dysregulated host response. Currently, besides (surgical) source control (e.g., control of bleeding or drainage of abscesses) and administration of antimicrobial drugs, therapeutic approaches are limited to supportive care. Advances in our understanding of the key pathophysiological pathways involved in the excessive inflammation triggered by trauma, sepsis and/or ischemia-reperfusion have had limited impact. The 28 article in this Research Topic focus on the molecular mechanisms behind (hyper) inflammation after sepsis or trauma, with special emphasis on preclinical and translational studies that target potential organ-protective and/or -resuscitative therapeutic strategies. Most studies report rodent models of trauma and elective surgery (three articles), non-microbial hyper-inflammation induced with endotoxin exposure (LPS; seven articles) and chemical pancreatitis (one article), and cecal ligation and puncture-induced sepsis (six articles). Additional papers summarize investigations of human material (six articles) or fully-resuscitated large animal models (two articles). These article are complimented by four reviews and a commentary
On the Location of the Gamma-ray Emission in the 2008 Outburst in the BL Lacertae Object AO 0235+164 through Observations across the Electromagnetic Spectrum
We present observations of a major outburst at centimeter, millimeter,
optical, X-ray, and gamma-ray wavelengths of the BL Lacertae object AO
0235+164. We analyze the timing of multi-waveband variations in the flux and
linear polarization, as well as changes in Very Long Baseline Array (VLBA)
images at 7mm with 0.15 milliarcsecond resolution. The association of the
events at different wavebands is confirmed at high statistical significance by
probability arguments and Monte-Carlo simulations. A series of sharp peaks in
optical linear polarization, as well as a pronounced maximum in the 7 mm
polarization of a superluminal jet knot, indicate rapid fluctuations in the
degree of ordering of the magnetic field. These results lead us to conclude
that the outburst occurred in the jet both in the quasi-stationary "core" and
in the superluminal knot, both parsecs downstream of the supermassive black
hole. We interpret the outburst as a consequence of the propagation of a
disturbance, elongated along the line of sight by light-travel time delays,
that passes through a standing recollimation shock in the core and propagates
down the jet to create the superluminal knot. The multi-wavelength light curves
vary together on long time-scales (months/years), but the correspondence is
poorer on shorter time-scales. This, as well as the variability of the
polarization and the dual location of the outburst, agrees with the
expectations of a multi-zone emission model in which turbulence plays a major
role in modulating the synchrotron and inverse Compton fluxes.Comment: Accepted for Publication in the Astrophysical Journal Letters. 7
pages (including 5 figures). Minor corrections with regard to previous
version, as proposed by the refere
Multi-band Optical Variability of the TeV Blazar PG 1553+113 in 2019
We report the flux and spectral variability of PG 1553+113 on intra-night
(IDV) to short-term timescales using BVRI data collected over 91 nights from 28
February to 8 November 2019 employing ten optical telescopes: three in
Bulgaria, two each in India and Serbia, and one each in Greece, Georgia, and
Latvia. We monitored the blazar quasi-simultaneously for 16 nights in the V and
R bands and 8 nights in the V, R, I bands and examined the light curves (LCs)
for intra-day flux and colour variations using two powerful tests: the
power-enhanced F-test and the nested ANOVA test. The source was found to be
significantly (> 99%) variable in 4 nights out of 27 in R-band, 1 out of 16 in
V-band, and 1 out of 6 nights in I-band. No temporal variations in the colours
were observed on IDV timescale. During the course of these observations the
total variation in R-band was 0.89 mag observed. We also investigated the
spectral energy distribution (SED) using B, V, R, and I band data. We found
optical spectral indices in the range of 0.878+-0.029 to 1.106+-0.065 by
fitting a power law to these SEDs of PG 1553+113. We found that the source
follows a bluer-when-brighter trend on IDV timescales. We discuss possible
physical causes of the observed spectral variability.Comment: 13 pages,8 figures, 7 tables, Accepted for publication in MNRA
Location of the Gamma-Ray Flaring Emission in the Parse-Scale Jet of the BL Lac Object AO 0235+164
We locate the gamma-ray and lower frequency emission in flares of the BL Lac
object AO 0235+164 at >12pc in the jet of the source from the central engine.
We employ time-dependent multi-spectral-range flux and linear polarization
monitoring observations, as well as ultra-high resolution (~0.15
milliarcsecond) imaging of the jet structure at lambda=7mm. The time
coincidence in the end of 2008 of the propagation of the brightest superluminal
feature detected in AO 0235+164 (Qs) with an extreme multi-spectral-range
(gamma-ray to radio) outburst, and an extremely high optical and 7mm (for Qs)
polarization degree provides strong evidence supporting that all these events
are related. This is confirmed at high significance by probability arguments
and Monte-Carlo simulations. These simulations show the unambiguous correlation
of the gamma-ray flaring state in the end of 2008 with those in the optical,
millimeter, and radio regime, as well as the connection of a prominent X-ray
flare in October 2008, and of a series of optical linear polarization peaks,
with the set of events in the end of 2008. The observations are interpreted as
the propagation of an extended moving perturbation through a re-collimation
structure at the end of the jet's acceleration and collimation zone.Comment: To be published in the proceedings of High Energy Phenomena in
Relativistic Outflows III (HEPRO III, IJMPCS). 6 page
Probing the Inner Jet of the Quasar PKS 1510-089 with Multi-waveband Monitoring during Strong Gamma-ray Activity
We present results from monitoring the multi-waveband flux, linear
polarization, and parsec-scale structure of the quasar PKS 1510-089,
concentrating on eight major gamma-ray flares that occurred during the interval
2009.0-2009.5. The gamma-ray peaks were essentially simultaneous with maxima at
optical wavelengths, although the flux ratio of the two wavebands varied by an
order of magnitude. The optical polarization vector rotated by 720 degrees
during a 5-day period encompassing six of these flares. This culminated in a
very bright, roughly 1 day, optical and gamma-ray flare as a bright knot of
emission passed through the highest-intensity, stationary feature (the "core")
seen in 43 GHz Very Long Baseline Array images. The knot continued to propagate
down the jet at an apparent speed of 22c and emit strongly at gamma-ray
energies as a months-long X-ray/radio outburst intensified. We interpret these
events as the result of the knot following a spiral path through a mainly
toroidal magnetic field pattern in the acceleration and collimation zone of the
jet, after which it passes through a standing shock in the 43 GHz core and then
continues downstream. In this picture, the rapid gamma-ray flares result from
scattering of infrared seed photons from a relatively slow sheath of the jet as
well as from optical synchrotron radiation in the faster spine. The 2006-2009.7
radio and X-ray flux variations are correlated at very high significance; we
conclude that the X-rays are mainly from inverse Compton scattering of infrared
seed photons by 20-40 MeV electrons.Comment: 10 pages of text + 5 figures, to be published in Astrophysical
Journal Letters in 201
Flaring Behavior of the Quasar 3C~454.3 across the Electromagnetic Spectrum
We analyze the behavior of the parsec-scale jet of the quasar 3C~454.3 during
pronounced flaring activity in 2005-2008. Three major disturbances propagated
down the jet along different trajectories with Lorentz factors 10. The
disturbances show a clear connection with millimeter-wave outbursts, in 2005
May/June, 2007 July, and 2007 December. High-amplitude optical events in the
-band light curve precede peaks of the millimeter-wave outbursts by 15-50
days. Each optical outburst is accompanied by an increase in X-ray activity. We
associate the optical outbursts with propagation of the superluminal knots and
derive the location of sites of energy dissipation in the form of radiation.
The most prominent and long-lasting of these, in 2005 May, occurred closer to
the black hole, while the outbursts with a shorter duration in 2005 Autumn and
in 2007 might be connected with the passage of a disturbance through the
millimeter-wave core of the jet. The optical outbursts, which coincide with the
passage of superluminal radio knots through the core, are accompanied by
systematic rotation of the position angle of optical linear polarization. Such
rotation appears to be a common feature during the early stages of flares in
blazars. We find correlations between optical variations and those at X-ray and
-ray energies. We conclude that the emergence of a superluminal knot
from the core yields a series of optical and high-energy outbursts, and that
the mm-wave core lies at the end of the jet's acceleration and collimation
zone.Comment: 57 pages, 23 figures, 8 tables (submitted to ApJ
Photographic and CCD Observations of the Nearby Clusters of Galaxies
The photometry is reported for galaxies in two clusters A1983, 2065 with redshifts 0.046, 0.072 respectively. The luminosity segregation is observed only within a magnitude from the brightest galaxy. The alignment of the galaxy major axis is observed in the Corona Borealis cluster. The intermediate distance clusters (0:05 ! z ! 0:15) will be studied by CCD mounted on 125cm RCh and 70cm meniscus type telescopes. I. INTRODUCTION Numerous studies of clusters of galaxies (CG) over the past two decades have added many important facts to our knowledge of their optical, X-ray and radio Radio properties (O'Dea 1986, Seitter 1984, Durrett 1985). Extensive investigation of the optical properties of CG have been carried out (Dressler 1978, Couch and Newell 1984, Butcher and Oemler 1985, Lugger 1986) in order to reveal global photometric properties of clusters. In the middle of 1970s a photometrical study of selected CG has been undertaken at Abastumani. The objects to be studied were selected ..