Random effects meta-analysis of the BMI association with 25(OH)D in men (A) (<i>n</i> = 20,950) and women (B) (<i>n</i> = 21,074).

<p>95% confidence intervals given by error bars.</p

Meta-analysis of the BMI allele score association with 25(OH)D (<i>n</i> = 31,120).

<p>95% confidence intervals given by error bars.</p

Meta-analysis of the BMI allele score association with BMI (<i>n</i> = 32,391), and the vitamin D synthesis (<i>n</i> = 35,873) and metabolism (<i>n</i> = 38,191) allele score association with 25(OH)D.

<p>95% confidence intervals given by error bars.</p

Summary of the coefficients used for IV ratio analyses.

a<p>Calculated as the ratio between the allele score association with the outcome and intermediate trait. Coefficients can be interpreted as percent change in the outcome by percent change in the intermediate trait.</p

Characteristics of the study cohorts stratified by sex.

a<p>Sample size based on available information on body mass index and 25(OH)D.</p

Meta-analysis of the synthesis allele score association with BMI (A) (<i>n</i> = 36,553) and the metabolism allele score association with BMI (B) (<i>n</i> = 40,367).

<p>95% confidence intervals given by error bars.</p

Results for the association between vitamin D SNPs/allele scores and BMI from the GIANT consortium.

<p>The GIANT meta-analyses consisted of 46 studies with up to 123,865 adults of European ancestry <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001383#pmed.1001383-Speliotes1" target="_blank">[23]</a>, including the 1958 British Birth Cohort, Framingham Heart study, Nurses' Health Study, Twins UK, UK Blood Services Common Control Collection, the Amish Family Osteoporosis Study, Health2000 GENMETS sub-sample, and Northern Finland Birth Cohort 1966, which were also part of the D-CarDia collaboration.</p>a<p>Calculated as described in Ehret et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001383#pmed.1001383-Ehret1" target="_blank">[35]</a>.</p

Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2.

<p>Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2.</p

Novel SNVs/Genes associated with BP traits in European ancestry.

<p>Novel SNVs/Genes associated with BP traits in European ancestry.</p

Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).

<p>Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).</p