Additional file 1: of WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

Table S1. Frequency of KMT2/MLL Mutations in Colon Cancer Cell Lines. Table S2. Sequences of individual siRNA and shRNA duplexes. Table S3. Sequences of qPCR primers. Figure S1. Validation of four oligos used for RNAi-mediated WDR5 depletion. Figure S2. Drug dose response curve for OICR-9429 in HCT116 cells. Figure S3. Representative propidium iodide cell cycle analysis following WDR5 depletion or OICR-9429 treatment in three colon cancer cell lines. Figure S4. Evaluation of apoptosis via Annexin V/PI staining following WDR5 depletion or OICR-9429 treatment in three colon cancer cell lines. Figure S5. RBBP5 depletion does not affect cell viability in a panel of colon cancer cell lines. (PDF 394 kb