Restructuring Information Technology Area: an experience report in the public service

One of the biggest challenges for an organizations IT area is to provide support so effective and efficient that the finalistics areas can achieve their missions, goals, indicators and compliance with legal requirements. The key to this problem is associated to information systems which are based on business models, being properly analyzed and specified, originating products that are close to business objectives and strategies. This article presents the experience with a complete restructuring proposal of the IT area, which includes changing internal processes, customization and deployment of software tools, involving organizational cultural changes. The proposal was implemented with the help of a framework, being used in many IT projects at the Ministry of Science, Technology and Innovation. When Complete the first execution cycle some organization benefits were verified, such as IT services quality, customer satisfaction and engagement, as well as transparency on IT projects

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead