3 research outputs found
Pilot Formulation Study of Ph-sensitive Gels
- Publication venue
- Sciendo
- Publication date
- 01/08/2023
- Field of study
Drugs remain for a short time on mucus membranes, such as oral, ocular, or nasal mucus, which are washed with physiological fluids. One of the possibilities to overcome this obstacle is the application of solutions that, due to the physiological environment or stimulus, turn into more viscous gels. These gels often also have mucoadhesive properties and the drug is released from them for a longer period. Carbomer 940 (C940), polycarbophil (PCP), and chitosan (CH) are gel-forming excipients, and the consistency of their solutions changes due to the concentration of protons (pH); therefore, they are referred to as pH-sensitive gelling agents. The aim of this study was to prepare pH-sensitive solutions that form gels in the pH of the oral cavity. We prepared water solutions with various concentrations of gel-forming excipients and evaluated the appearance, pH of the solution, injectability of the solution, and pH of gelation. By determining the pH of gelation, suitable concentrations (w/w) of the used polymers were found, namely, 0.1% C940, 0.225% PCP, and 2.5% CH with medium molecular weight (CHM). The 0.1% C940 and 0.225% PCP solutions were injectable through the syringe with the smallest 0.5 mm needle diameter. The 2.5% CHM solution was not injectable even through the syringe with the largest 0.8 mm needle diameter. Solgels prepared at the determined concentrations were evaluated by a dissolution test in a pH 6.8 phosphate buffer using methylene blue (MB) as a model substance. After 60 min of dissolution, 77.04% ± 5.94%, 48.85% ± 5.74%, and 77.35% ± 4.98% of MB were released from samples with C940, PCP, and CHM, respectively. The dissolution of the C940 and CHM samples took place according to the Korsmeyer–Peppas kinetic model (R2 0.999 ± 0.001, 0.978 ± 0.003) and of the PCP samples took place according to the first-order model (R2 0.994 ± 0.001). The 0.225% PCP pH-sensitive gel showed the most advantageous properties in terms of injectability, pH gelation, and prolonged release of MB
Food Insecurity in HIV-Hepatitis C Virus Co-infected Individuals in Canada: The Importance of Co-morbidities
- Author
- A Anema
- A Anema
- A Anema
- A Anema
- A Anema
- A Campa
- A Kendall
- A-M Hamelin
- AJ Coleman-Jensen
- Anne-Marie Hamelin
- Aranka Anema
- AW Singer
- C Strike
- D Belle
- DA Himmelgreen
- DB Rubin
- EA Wang
- EJC Ameijden van
- Erica E. M. Moodie
- FJ Santolaria-Fernández
- G Bickel
- Gilles Paradis
- JL Goulet
- JM Mrus
- Joseph Cox
- JT Cook
- K Vasarhelyi
- Kathleen C. Rollet-Kurhajec
- L Normen
- LC Ivers
- M Hull
- M Tavakol
- Marina B. Klein
- MB Klein
- MB Klein
- MB Klein
- N Dachner
- N Romero-Daza
- P Braitstein
- RS Remis
- S Young
- SA Andersen
- SB Rourke
- SC Kalichman
- SC Kalichman
- SD Weiser
- SD Weiser
- SD Weiser
- Sean B. Rourke
- SG Kertesz
- SH Roshanafshar
- Sharon L. Walmsley
- SI Kirkpatrick
- T Rhodes
- T Rhodes
- Taylor McLinden
- V Lux
- V Tarasuk
- W Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).
- Author
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- Matengeni A
- Mateos E
- Matiko E
- Matlhaba O
- Matlhagela K
- Matsheka M
- Matteelli A
- Matthews G
- Matthews PC
- Maurer M
- Maurer M
- Mave V
- Mavedzenge SN
- Mavengere Y
- Mayer K
- Mayer K
- Mayer KH
- Mayer KH
- Mboh E
- Mboh E
- McCallister S
- McCallister S
- McCauley M
- McCauley M
- McCloskey R
- Mccloskey R
- McCloskey R
- McComsey G
- McCoy S
- McCoy SI
- Mccoy SI
- McElrath J
- Mcfarland W
- McGowan CC
- McGowan I
- Mcgrath C
- Mchugh G
- McHutchison JG
- Mcingana M
- McIntyre J
- McKinstry L
- McMahan V
- McMahon J
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- Mejía-Villatoro C
- Mekviwattanawan S
- Melbourne K
- Mellado MJ
- Merati TP
- Mercier J
- Merlini E
- Mesplède T
- Metivier S
- Metras M-E
- Meza R
- Mhango E
- Mhango E
- Miailhes P
- Micci L
- Michael N
- Midiani D
- Miller C
- Miller R
- Miller WC
- Miller WC
- Millett G
- Milloy M-J
- Milloy M-J
- Milloy M-J
- Milloy M-J
- Milloy MJ
- Milloy MJ
- Mills L
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- Min JE
- Min JE
- Min Z
- Miro JM
- Mirzazadeh A
- Mirzazadeh A
- Miyahara S
- Mocroft A
- Moebus S
- Mofolo I
- Mohammed T
- Mohapi L
- Mokoena I
- Mollan K
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- Money D
- Money D
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- Monforte AD
- Montaner J
- Montaner J
- Montaner J
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- Montefiori D
- Monteiro P
- Moodie EE
- Moore D
- Moore P
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- Moracco KE
- Morales-Ramirez J
- Moran ME
- Moreira RI
- Moreno A
- Moreno S
- Mori M
- Morissette C
- Morris L
- Moses A
- Moshgabadi N
- Mosoko JJ
- Mota T
- Mothopeng T
- Moukambi F
- Mourez T
- Moyo S
- Moyo S
- Moyo T
- Mpofu D
- Msandiwa R
- Mshana G
- Msukwa MT
- Mtande T
- Mudender F
- Muffih PT
- Mugo C
- Mugo NR
- Mugurungi O
- Mugurungi O
- Mugyenyi P
- Mujuru HA
- Mukerjee P
- Mukui I
- Mulawa M
- Mulder N
- Mulema V
- Mullins JI
- Munsakul W
- Munyati S
- Murakami-Ogasawara A
- Murakami-Ogasawara A
- Murphy RL
- Murray C
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- Murray K
- Musarandega R
- Musau S
- Mushavi A
- Mushavi A
- Musiime V
- Musinguzi J
- Musomba RZ
- Musonda R
- Mustafa M
- Mutanha N
- Mutanhaurwa R
- Muula A
- Muñoz-Fernández MÁ
- Mwale M
- Mwangomba L
- Mwanyumba S
- Myer L
- Myer L
- Myer L
- Myer L
- Myers S
- Nabitaka L
- Naggie S
- Naidoo K
- Nair G
- Najarro K
- Nalugoda F
- Namey E
- Namuwenge N
- Nanda K
- Nankya I
- Naranbhai V
- Natumanya E
- Ncube G
- Ndhlovu L
- Ndhlovu LC
- Ndjoyi-Mbiguino A
- Ndlovu B
- Ndulue N
- Ndung'u T
- Ndung'u T
- Neilands TB
- Nelson M
- Nelson W
- Neumann T
- Newell M-L
- Neytra S
- Nganga L
- Nganga L
- Ngo-Giang-Huong N
- Nguimkeu P
- Nguyen BC
- Nguyen HH
- Nguyen HL
- Nguyen MS
- Nguyen P
- Nguyen T
- Nhan T
- Nhando N
- Nicholas S
- Nickel G
- Niehues T
- Nielsen K
- Nikolopoulos G
- Nimitvilai S
- Nitayaphan S
- Njau P
- Njuguna I
- Noe S
- Nordio J
- Nosyk B
- Nosyk B
- Nsumba MS
- Ntombela F
- Nunez A
- Nunez A
- Nyandindi C
- Nyirenda M
- Nzengui GFN
- O'Brien M
- O'Connell R
- O'Doherty U
- Obel N
- Ochoa-Moreno I
- Oishi K
- Okala SG
- Okesola N
- Okitolonda E
- Okonji E
- Okonji E
- Omanga E
- Omanga E
- Omolo D
- Orkin C
- Orne-Gliemann J
- Orne-Gliemann J
- Orrell C
- Osman N
- Osmand T
- Osoti A
- Ospina-Norvell C
- Ostrowski M
- Ou S-S
- Ou S-S
- Ou S-S
- Ou SS
- Ouattara M
- Ouedraogo G
- Owen SM
- Padgett D
- Padian N
- Padian NS
- Padian NS
- Pageaux G-P
- Paiardini M
- Palma P
- Palmer S
- Palou E
- Pan J
- Panchia R
- Panchia R
- Pang PS
- Pankam T
- Pannetier J
- Panteleev A
- Pape JW
- Papoyan A
- Parades Z
- Paraskevis D
- Parikh S
- Parslow T
- Pascale J
- Pate KM
- Patel M
- Patel V
- Pattanasin S
- Peacock D
- Peeling R
- Pence BW
- Pendse R
- Perelson A
- Perez A
- Perry B
- Peters P
- Peters PJ
- Petersen M
- Peterson C
- Petit L
- Peton N
- Petro G
- Pettifor A
- Pettifor A
- Pettifor AP
- Peyrani P
- Peytavin G
- Peytavin G
- Peytavin G
- Pham HT
- Phanuphak N
- Phanuphak N
- Phanuphak N
- Phanuphak P
- Phanuphak P
- Phanuphak P
- Phanuphak P
- Phaswana-Mafuya N
- Phillips T
- Piatak M
- Piazza P
- Pick N
- Pilcher C
- Pillay D
- Pillay D
- Pillay D
- Pillay S
- Pina C
- Ping L-H
- Pinyakorn S
- Piper J
- Pitche V
- Pitisuttithum P
- Piwowar-Manning E
- Piwowar-Manning E
- Piwowar-Manning E
- Piwowar-Manning E
- Planas D
- Plantier J-C
- Platt HL
- Plazy M
- Plettenberg A
- Plotkin M
- Plummer A
- Podlekareva DN
- Pohlmeyer C
- Polacino P
- Pontones P
- Pontones P
- Poon A
- Poon AF
- Poon AFY
- Porcella SF
- Porcella SF
- Porras G
- Porter K
- Portilla J
- Post F
- Post FA
- Post FA
- Powers KA
- Powis K
- Pozniak A
- Pozniak A
- Prasithsirikul W
- Prasitsuebsai W
- Prasitsuebsai W
- Prentice H
- Prestage G
- Promda N
- Prozesky H
- Prueksakaew P
- Prueksakaew P
- Psichogiou M
- Pujol BG
- Purcell D
- Puren A
- Puthanakit T
- Puttkammer N
- Pyra M
- Quant C
- Queen S
- Quereda C
- Quinn T
- Quinn T
- Quinn TC
- Quirk E
- Quiroz-Morales V
- Rabezanahary H
- Racz L
- Raffi F
- Rain-Taljaard R
- Rajasingham R
- Rajkotia Y
- Rakhmanina N
- Ramachandran A
- Ramachandran S
- Ramapuram J
- Ramogothobeng K
- Rangel G
- Rao S
- Ratanasuwan W
- Ratcliff A
- Ravalihasy A
- Ravelomanana NLR
- Ravindran P
- Rawangban B
- Rawat A
- Ray N
- Raymond A
- Rebeiro PF
- Redd A
- Redd AD
- Reed JS
- Rees H
- Reeves RK
- Reidner G
- Reimann K
- Reinsch N
- Reliquet V
- Rerks-Ngarm S
- Reyes H
- Reyes-Terán G
- Reynolds S
- Reza T
- Richardson B
- Richardson L
- Richman D
- Rinaldo CR
- Riviere C
- Robb M
- Robertson M
- Robinson J
- Robison J
- Rocha MM
- Roche M
- Rockstroh JK
- Rodrigues V
- Rodriguez B
- Rodriguez F
- Rolland M
- Rollet-Kurhajec K
- Ronen K
- Rooney J
- Rosalind P-R
- Roseberry J
- Roseberry JC
- Rosen S
- Rosenberg N
- Rosenthal E
- Rosenthal K
- Rountree W
- Routy J-P
- Rouzioux C
- Rowhani-Rahbar A
- Rowland-Jones S
- Roxby A
- Roy É
- Ruane PJ
- Rudy B
- Rutherford A
- Rutledge B
- Ruxrungtham K
- Ryan E
- Saag M
- Saag MS
- Sabsanong P
- Sabuni N
- Sacha JB
- Saeed S
- Saengtawan P
- Saez-Cirion A
- Saidi F
- Salazar-Vizcaya L
- Saleh S
- Salgado M
- Salmon D
- Salo E
- Samson L
- Samson L
- Samsunder N
- Sanchez A
- Sandoval M
- Sandstrom P
- Sang N
- Santangelo P
- Santos RB
- Sathane I
- Sato P
- Satumay K
- Sauve L
- Sauve L
- Schadendorf D
- Schafer J
- Schechter M
- Schechter MT
- Scheepers E
- Scheepers E
- Scherpbier HJ
- Schley A
- Schmid RM
- Schmitz K
- Schnippel K
- Schomaker M
- Schomaker M
- Schramm B
- Schrijvers R
- Schultze A
- Schulze C
- Schwartz S
- Schwarz M
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- Schürmann D
- Scully E
- Seclen-Palacin J
- Sedaghat A
- Sekaly R
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- Selin A
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- Serwadda D
- Sevelius JM
- Sevinsky H
- Shackleton CR
- Shah M
- Shamblaw D
- Shang H
- Shankar A
- Shannon K
- Shao Y
- Shapiro R
- Sharifi H
- Shattock A
- Shattock R
- Shattock RJ
- Shaughnessy M
- Shaw A
- Shearer K
- Shen X
- Shengelia N
- Shepherd BE
- Shepherd BE
- Sherr K
- Sherwood J
- Shields J
- Shields R
- Shighata C
- Shikuma C
- Shingadia D
- Shirk E
- Shive C
- Shokoohi M
- Shwartz J
- Sibanda E
- Sibanyoni M
- Siberry G
- Sievers M
- Sievers M
- Sikaris K
- Silicano J
- Silicano R
- Siliciano RF
- Silima M
- Sim B
- Simba O
- Simon K
- Simoni JM
- Simpson S
- Singa B
- Singer J
- Singer J
- Singh B
- Singtoroj T
- Singtoroj T
- Sirisanthana T
- Sirivichayakul S
- Siriwachirachai T
- Sithole B
- Skowronska E
- Skrahin A
- Slyker J
- Slyker JA
- Smith D
- Smith KN
- Sobotha C
- Sodhi S
- Sogni P
- Sohn AH
- Solomon A
- Solomon MM
- Solomon S
- Somsouk M
- Sonza S
- Soto-Nava M
- Soto-Nava M
- Soule M
- Spinner CD
- Spoulou V
- Spörri A
- Sripan P
- Sriporn A
- Ssali F
- Ssekubugu R
- Ssemmondo E
- Stahlman S
- Stamm LM
- Stanley C
- Stekler J
- Stevens M
- Stinson K
- Stinson K
- Stintzi A
- Stirratt M
- Stirratt M
- Stojiljkovic T
- Strathdee S
- Strathdee S
- Strathdee SA
- Strumpf EC
- Struthers H
- Stuart R
- Sudjaritruk T
- Sudjaritruk T
- Sugandhi N
- Sulaberidze L
- Sulkowski M
- Sulkowski MS
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- Sun X
- Sungkanuparph S
- Sunseri N
- Supervie V
- Suthar A
- Suttichom D
- Swanstrom R
- Swanstrom R
- Sweitzer S
- Swindells S
- Switzer WM
- Sylla M
- Sypsa V
- Szumilin E
- Taha T
- Taiwo B
- Takebe Y
- Tal K
- Taljjard D
- Tang W
- Tang W
- Tanser F
- Tanser F
- Tapia K
- Taruberekera N
- Tayea A
- Taylor A
- Taylor J
- Tayong G
- Teague A
- Techapornroong M
- Tee KK
- Teeraananchai S
- Tenakoon S
- Tene G
- Tenthani L
- Teodoro E
- Teppler H
- Terris-Prestholt F
- Terán GR
- Thai H
- Thirumurthy H
- Thirumurthy H
- Thirumurthy H
- Thomas KK
- Thomas R
- Thompson D
- Thompson LH
- Thompson M
- Tih PM
- Timimi HB
- Tippanonth N
- Tiraboschi JM
- Toby M
- Toibaro J
- Tollman S
- Tomaras G
- Torres S
- Townley E
- Trahan M-J
- Tran HT
- Traore B
- Trapence G
- Treves-Kagan S
- Treves-Kagan S
- Trichavaroj R
- Trichavaroj R
- Trinh R
- Trunfio M
- Truong KH
- Trypsteen W
- Tsereteli N
- Tucker J
- Tumba N
- Tumbare E
- Tumwesigye E
- Turrini F
- Turyamureeba B
- Twine R
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- Twine R
- Uebel KE
- Umar E
- Urien S
- Valantin MA
- Valenzuela-Ponce H
- Valenzuela-Ponce H
- van der Elst L
- Van Eygen V
- van Heerden A
- van Lettow M
- Van Lint C
- Van Lunzen J
- Van Nguyen L
- Van Nguyen TT
- van Oosterhout J
- van Oosterhout JJ
- Van Rompay K
- van Rooyen H
- Van Schalkwyk J
- Vandekerckhove L
- Vandendriessche A
- Vasarhelyi K
- Vaudry W
- Vaudry W
- Veloso VG
- Veloso VG
- Venter F
- Ventura A
- Verhofstede C
- Vermillion M
- Vernazza P
- Vervisch K
- Vets S
- Viana R
- Vibeke R
- Vicenzi E
- Vicol LA
- Viljoen K
- Villinger F
- Vincent T
- Vitoria M
- Vittinghoff E
- Volberding P
- Volokha A
- von Werder A
- Vu QD
- Wagner A
- Wagner R
- Wagner T
- Wainberg M
- Wainfen W
- Walker BD
- Walker BD
- Walker-Sperling V
- Wallis C
- Walmsley S
- Wamalwa D
- Wamalwa D
- Wambura M
- Wamicwe J
- Wanasiri P
- Wang C
- Wang J
- Wang J
- Wang Z
- Warnke A
- Warszawski J
- Watadzaushe C
- Waterhouse D
- Wawer M
- Weaver E
- Webb GM
- Wei C
- Wei X
- Weidle P
- Weiser B
- Weiss H
- Weissenhorn W
- Welty T
- Welty T
- Wendoh J
- Wenzi LK
- Werb D
- Wertheim JO
- Westgard T
- Wiesner L
- Wijayaratne S
- Wilen C
- Wilkinson L
- Williams T
- Wilson CM
- Wilson D
- Wimonsate W
- Wittkop L
- Woelk G
- Wolf E
- Wolff M
- Wolters L
- Wood E
- Wood E
- Wood E
- Wood E
- Woods C
- Wu HL
- Wu V
- Wyles D
- Wylie JL
- Xaba T
- Xia G
- Xiao H
- Xing Y
- Xu D
- Xu J
- Xu X
- Yang B
- Yang JC
- Yang L
- Yao KA
- Yassi A
- Yates N
- Yazdanpanah Y
- Yin M
- Yindom L-M
- Yotebieng M
- Young J
- Young P
- Youngleson M
- Yu Y
- Zablotska I
- Zamor P
- Zang O
- Zash R
- Zerbe A
- Zhang M
- Zhang Y
- Zhang Y
- Zhou S
- Zhuang M
- Ziegler JB
- Zink A
- Zink C
- Zolla-Pazner S
- Zolopa A
- Zolowere DB
- Zou H
- Zuma N
- Ásbjörnsdóttir KH
- Ávila-Ríos S
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2015
- Field of study