2 research outputs found
Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line
No full textA total
synthesis of the natural product 6-deoxypladienolide D
(<b>1</b>) has been achieved. Two noteworthy attributes of the
synthesis are (1) a late-stage allylic oxidation which proceeds with
full chemo-, regio-, and diastereoselectivity and (2) the development
of a scalable and cost-effective synthetic route to support drug discovery
efforts. 6-Deoxypladienolide D (<b>1</b>) demonstrates potent
growth inhibition in a mutant SF3B1 cancer cell line, high binding
affinity to the SF3b complex, and inhibition of pre-mRNA splicing
Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line
No full textA total
synthesis of the natural product 6-deoxypladienolide D
(<b>1</b>) has been achieved. Two noteworthy attributes of the
synthesis are (1) a late-stage allylic oxidation which proceeds with
full chemo-, regio-, and diastereoselectivity and (2) the development
of a scalable and cost-effective synthetic route to support drug discovery
efforts. 6-Deoxypladienolide D (<b>1</b>) demonstrates potent
growth inhibition in a mutant SF3B1 cancer cell line, high binding
affinity to the SF3b complex, and inhibition of pre-mRNA splicing
