萎縮性胃炎とガストリンの実験胃癌に及ぼす影響

In the present experiment the influence of atrophic mucosa and resulting endogenous hypergastrinemia on the induction of gastric cancer by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined in male Donryu rats. All rats were fed MNNG in tap water for 6 months and were killed after more 5 months. The incidence of gastric cancer was 55% in rats with atrophic gastritis and hypergastrinemia, which is significantly higher than the incidence of 10 % observed in rats treated with MNNG alone. Gastric cancer was not found in any rats with atrophic gastritis without associating with hypergastrinemia. These data suggest that atrophic mucosa and resulting hypergastrinemia are important in development and growth of gastric cancer in rats.This work was supported by a grant from the Ministry of Education (1976-1977)

糖尿病ラットの消化管における VIP 作動神経

Diabetic gastroenteropathy developed in about 70% of the rats with diabetes induced by streptozotocin. These rats were associated with diarrhea, gastric paresis, and small intestinal stasis. About 30% of the rats with diabetic gastroenteropathy had narrowed and contracted segments of the lower esophagus and 70% of the colon of the rats showed dilated and contracted segments. Changes in the distribution of VIP-like immunoreactivities in nerve plexuses of the gastrointestinal wall which were observed with destruction of the autonomic nerves (both submucosal and myenteric plexuses) could be one of the plausible causes of diabetic gastroenteropathy induced by streptozotocin, although the precise mechanism of the development of diabetic gastroenteropathy in rats remains obscure

Two Cases of Atraumatic Chylous Ascites Characterized by Hypotriglyceridemia and Partially Managed with an Oral Fat-Free Elemental Diet

Most cases of chylous ascites occur after surgery, but it also develops in nonoperative cases, although rarely. Such cases are often difficult to treat. In this study, we treated 2 cases of atraumatic chylous ascites, which were controlled by combining diuretic treatment with an oral fat-free elemental diet (Elental®, EA Pharma Co., Ltd., Tokyo, Japan). Elental can provide oral nutrition compatible with a lipid-restricted diet, which may be useful for control of chylous ascites. We report on these cases, including literature review-based considerations

Presence of perivenular elastic fibers in nonalcoholic steatohepatitis Fibrosis Stage III

Elastic fibers appear in extensive old fibrotic foci in general. We examined an association between hepatic fibrosis stage and the presence of perivenular elastic fibers in nonalcoholic steatohepatitis (NASH). A total of 48 liver needle biopsy specimens were used, taken from 48 cases with NASH. Fibrosis Stage (Brunt E, et al. Am. J. Gastroenterol. 1999) of the cases was as follows; six Fibrosis Stage I, twenty-two Fibrosis Stage II, and twenty Fibrosis Stage III. We examined Orcein stain sections in all of the liver needle biopsy specimens. In all twenty Fibrosis Stage III cases, perivenular elastic fiber bundles were observed. In contrast, perivenular elastic fibers were detected only in one of the six Fibrosis Stage I and two of the twenty-two Fibrosis Stage II cases. In liver needle biopsy specimens of NASH, detection of perivenular elastic fibers is useful in deciding Fibrosis Stage III