Initial operation of perpendicular line-of-sight compact neutron emission spectrometer in the large helical device

The perpendicular line-of-sight compact neutron emission spectrometer (perpendicular CNES) was newly installed to understand the helically trapped fast-ion behavior through deuterium–deuterium (D–D) neutron energy spectrum measurement in the Large Helical Device (LHD). The energy calibration of the EJ-301 liquid scintillation detector system for perpendicular CNES was performed on an accelerator-based D–D neutron source. We installed two EJ-301 liquid scintillation detectors, which view the LHD plasma vertically from the lower side through the multichannel collimator. The D–D neutron energy spectrum was measured in a deuterium perpendicular-neutral-beam-heated deuterium plasma. By the derivative unfolding technique, it was found that the D–D neutron energy spectrum had a double-humped shape with peaks at ∼2.33 and ∼2.65 MeV. D–D neutron energy spectrum was calculated based on the fast ion distribution function using guiding center orbit-following models considering the detector’s energy resolution. The calculated peak energies in the D–D neutron energy spectrum almost match the experiment. In addition, a feasibility study toward the measurement of the energy distribution of ion-cyclotron-range-of-frequency-wave-accelerated beam ions was performed

Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia

Neurological dementias such as Alzheimer’s disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregates in order to prevent and/or delay the progression of dementia in these ailments. In this report, we investigated the effects of spearmint extract (SME) and rosmarinic acid (RA; the major component of SME) on the amyloid fibril formation reactions of αSyn, Aβ, and Tau proteins in vitro. SME or RA was added to soluble samples of each protein and the formation of fibrils was monitored by thioflavin T (ThioT) binding assays and transmission electron microscopy (TEM). We also evaluated whether preformed amyloid fibrils could be dissolved by the addition of RA. Our results reveal for the first time that SME and RA both suppress amyloid fibril formation, and that RA could disassemble preformed fibrils of αSyn, Aβ, and Tau into non-toxic species. Our results suggest that SME and RA may potentially suppress amyloid fibrils implicated in the progression of Alzheimer’s disease and Lewy body dementia in vivo, as well

Sensitivity of Gaussian energy broadening function of MCNP pulse height spectra on CLYC7 scintillation detector

The Cs2LiYCl6:Ce crystal (CLYC) is an inorganic scintillator which has been developed for the γ-ray and neutron measurement with the high detection efficiency, high resolution, and no need unfolding technique. To enhance the measurement of the fast neutron, the CLYC with 7Li-enrichment (CLYC7) scintillator is developed. In this work, the response of the CLYC7 detector to γ-ray is obtained using 137Cs γ-ray calibration source and calculated using Monte Carlo N-Particle transport code (MCNP). A comparison of measured and calculated γ-rays spectra is complicated by the fact that physical radiation detectors have finite energy resolution. In this study, we treated detector energy resolution effect by Gaussian energy broadening (GEB) in MCNP pulse height spectra calculation. We observe the parameters in the GEB function which provides simulation spectrum matches the experiment spectrum, especially on the photopeak region. The detail sensitivity of GEB function on CLYC7 scintillation detector is presented in this work

Neutron Shielding Design of Infrared Imaging Video Bolometer for LHD Deuterium Experiment

InfraRed imaging video bolometer (IRVB) is a powerful diagnostic for the plasma radiation measurement. Study on plasma radiation phenomena, e.g., plasma detachment, is one of the crucial issues to realize a fusion reactor. In order to apply the IRVB to such a study, a shielding is required to protect an IR camera from neutron irradiation. In the large helical device (LHD), deuterium experiment has started in 2017. Then, the shielding was designed using MCNP6 code with the 3-D modeling of LHD. The guideline of the neutron flux for the design was determined by the operational experience in JT-60U tokamak and by the result of the irradiation in OKTAVIAN. The strong neutron flux due to the location close to the vacuum vessel and the influx through the lens hole were reduced sufficiently. The designed shielding was applied to the LHD deuterium experiments and the IRVB with the shielding could be operated successfully without any dead pixels in the neutron emission rate up to 3.3×10 15 n·s -1 , which is the maximum rate in the first experimental campaign and in the total neutron emission of 3.6×10 18 n. These correspond to the neutron emission rate of 2.9×10 7 n·s -1 and the total neutron emission of 3.2 × 10 10 n at around the IR camera

Evaluation of tritium production rate in a blanket mock-up using a compact fusion neutron source

We report a neutronics study of a blanket mock-up using a discharge-type compact fusion neutron source. Deuterium–deuterium fusion neutrons were irradiated to the mock-ups composed of tritium breeder and neutron reflector/moderator. The tritium production rate (TPR) per source neutron was measured by a single-crystal diamond detector with a 6Li-enriched lithium fluoride film convertor after the calibration process. Despite the low neutron yield, energetic alpha and triton particles via 6Li(n, t)α neutron capture as well as 12C via elastic scattering were successfully detected by the SDD with high signal to noise ratios. The TPRs were experimentally evaluated with errors of 8.4%–8.5% at the 1σ level at the positions with high thermal neutron fluxes where the errors were dominantly introduced by uncertainties in the monitoring of the neutron production rate. The calculated to experimental (C/E) values of TPR were evaluated to be 0.91–1.27 (FENDL-2.1) and 0.94–1.28 (FENDL-3.1). As the neutron source can generate 14 MeV neutrons using a mixed gas of deuterium and tritium, this approach provides more opportunities for blanket neutronics experiments

Thermal neutron flux evaluation by a single crystal CVD diamond detector in LHD deuterium experiment

The single crystal CVD diamond detector (SDD) was installed in the torus hall of the Large Helical Device (LHD) to measure neutrons with high time resolution and neutron energy resolution. The LiF foil with 95.62 % of 6Li isotope enrichment pasted on the detector was used as the thermal neutron convertor as the energetic ions of 2.0 MeV alpha and 2.7 MeV triton particles generated in LiF foil and deposited the energy into SDD. SDD were exposed to the neutron field in the torus hall of the LHD during the 2nd campaign of the deuterium experiment. The total pulse height in SDD was linearly propotional to the neutron yield in a plasma operation in LHD over 4 orders of magnitude. The energetic alpha and triton were separately measured by SDD with LiF with the thickness of 1.9 μm, although SDD with LiF with the thickness of 350 μm showed a broadened peak due to the large energy loss of energetic particles generated in the bulk of LiF. The modeling with MCNP and PHITS codes well interpreted the pulse height spectra for SDD with LiF with different thicknesses. The results above demonstrated the sufficient time resolution and energy discrimination of SDD used in this work

Magnetic configuration effects on TAE-induced losses and a comparison with the orbit-following model in the Large Helical Device

Fast-ion losses from Large Helical Device (LHD) plasmas due to toroidal Alfvén eigenmodes (TAEs) were measured by a scintillator-based lost fast-ion probe (SLIP) to understand the loss processes. TAE-induced losses measured by the SLIP appeared in energy E ranges of around 50–180 keV with pitch angles χ between 35°–45°, and increased with the increase in TAE amplitudes. Position shifts of the magnetic axis due to a finite plasma pressure led not only to an increase in TAE-induced losses but also to a stronger scaling of fast-ion losses on TAE amplitudes. Characteristics of the observed fast-ion losses were compared with a numerical simulation based on orbit-following models in which the TAE fluctuations are taken into account. The calculation indicated that the number of lost fast ions reaching the SLIP increased with the increase in the TAE amplitude at the TAE gap. Moreover, the calculated dependence of fast-ion loss fluxes on the fluctuation amplitude became stronger in the case of large magnetic axis shifts, compared with the case of smaller shifts, as was observed in the experiments. The simulation results agreed qualitatively with the experimental observations in the LHD

Case report: a case of intractable Meniere's disease treated with autogenic training

<p>Abstract</p> <p>Background</p> <p>Psychological stress plays an important role in the onset and course of Meniere's disease. Surgical therapy and intratympanic gentamicin treatment are options for cases that are intractable to conventional medical therapy. Psychotherapy, however, including autogenic training (AT), which can be used for general relaxation, is not widely accepted. This paper describes the successful administration of AT in a subject suffering from intractable Meniere's disease.</p> <p>Case presentation</p> <p>A 51-year-old male patient has suffered from fluctuating right sensorineural hearing loss with vertigo since 1994. In May 2002, he was first admitted to our hospital due to a severe vertigo attack accompanied by right sensorineural hearing loss. Spontaneous nystagmus toward the right side was observed. Since April 2004, he has experienced vertigo spells with right-sided tinnitus a few times per month that are intractable to conventional medical therapy. After four months, tympanic tube insertion was preformed in the right tympanic membrane. Intratympanic injection of dexamethasone was ineffective. He refused Meniett therapy and intratympanic gentamicin injection. In addition to his vertigo spells, he suffered from insomnia, tinnitus, and anxiety. Tranquilizers such as benzodiazepines and antidepressants such as serotonin selective re-uptake inhibitors (SSRIs) failed to stop the vertigo and only slightly improved his insomnia. In December 2006, the patient began psychological counseling with a psychotherapist. After brief psychological counseling along with cognitive behavior therapy (CBT), he began AT. He diligently and regularly continued his AT training in his home according to a written timetable. His insomnia, tinnitus, and vertigo spells disappeared within a few weeks after only four psychotherapy sessions. In order to master the six standard formulas of AT, he underwent two more sessions. Thereafter, he underwent follow-up for 9 months with no additional treatment. He is now free from drugs, including tranquilizers, and has continued AT. No additional treatment was performed. When we examined him <b>six </b>and nine months later for follow-up, he was free of vertigo and insomnia.</p> <p>Conclusion</p> <p>AT together with CBT can be a viable and palatable treatment option for Meniere's disease patients who are not responsive to other therapies.</p