On the Security of TrCBC

TrCBC is a variant of CBC-MAC which appeared in Information Processing Letters, 112(7):302-307, 2012. The authors claimed TrCBC to be a secure message authentication code (MAC) with some interesting properties. If TrCBC is instantiated with a block cipher with block length n, then it requires ⌈λ/n⌉ block cipher calls for authenticating a λ-bit message and requires a single key, which is the block cipher key. The authors state that TrCBC can have tag lengths of size less than n/2. We show that with high probability, an adversary can forge TrCBC with tag length n/2 − 1 with just three queries. The attack that we show can be applied to forge a large class of messages. The authors proved TrCBC to be a pseudorandom function (PRF). A scrutiny of the claimed PRF bound shows that for some recommended values of tag lengths, the bound turns out to be quite large. Thus, the security theorem does not imply security of TrCBC for all recommended tag lengths

Tight Security Bound of 2k-LightMAC Plus

In ASIACRYPT\u2717, Naito proposed a beyond-birthday-bound variant of the LightMAC construction, called LightMAC_Plus, which is built on three independently keyed $n$-bit block ciphers, and showed that the construction achieves $2n/3$-bits PRF security. Later, Kim et al. claimed (without giving any formal proof) its security bound to $2^{3n/4}$. In FSE\u2718, Datta et al. have proposed a two-keyed variant of the LightMAC_Plus construction, called 2k-LightMAC_Plus, which is built on two independently keyed $n$-bit block ciphers, and showed that the construction achieves $2n/3$-bits PRF security. In this paper, we show a tight security bound on the 2k-LightMAC_Plus construction. In particular, we show that it provably achieves security up to $2^{3n/4}$ queries. We also exhibit a matching attack on the construction with the same query complexity and hence establishing the tightness of the security bound. To the best of our knowledge, this is the first work that provably shows a message length independent $3n/4$-bit tight security bound on a block cipher based variable input length PRF with two block cipher keys

Designing Tweakable Enciphering Schemes Using Public Permutations

A tweakable enciphering scheme (TES) is a length preserving (tweakable) encryption scheme that provides (tweakable) strong pseudorandom permutation security on arbitrarily long messages. TES is traditionally built using block ciphers and the security of the mode depends on the strong pseudorandom permutation security of the underlying block cipher. In this paper, we construct TESs using public random permutations. Public random permutations are being considered as a replacement of block cipher in several cryptographic schemes including AEs, MACs, etc. However, to our knowledge, a systematic study of constructing TES using public random permutations is missing. In this paper, we give a generic construction of a TES which uses a public random permutation, a length expanding public permutation based PRF and a hash function which is both almost xor universal and almost regular. Further, we propose a concrete length expanding public permutation based PRF construction. We also propose a single keyed TES using a public random permutation and an AXU and almost regular hash function

Pre-operative assessment of impacted mandibular third molar and inferior alveolar canal using orthopantomograhpy and cone beam computed tomography

The aim of this study was to assess the proximity and relation of impacted mandibular third molar and inferior alveolar canal on orthopantomogram and cone beam computed tomography (CBCT). Sixty impacted mandibular third molars having close proximity with the  inferior alveolar canal were included. CBCT images were done to determine the exact location and relationship of impacted third molar tooth and inferior alveolar canal. We assessed the radiographic signs from orthopantomogram, the course of  inferior alveolar canal and proximity to the third molar tooth in CBCT. The buccal course of  inferior alveolar canal was most frequently detected (n=36) in CBCT findings. The impacted lower third molar roots were 55% contact with the  inferior alveolar canal and 45% separate from the canal. On orthopantomogram, the following signs were strongly correlated with actual contact: Superimposed relationship between the third molar and the inferior alveolar canal. CBCT is useful as a presurgical planning in patients with impacted mandibular third molar showing close proximity to the  inferior alveolar canal

Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages

Macrophage infiltration into adipose tissue during obesity and their phenotypic conversion from anti-inflammatory M2 to proinflammatory M1 subtype significantly contributes to develop a link between inflammation and insulin resistance; signaling molecule(s) for these events, however, remains poorly understood. We demonstrate here that excess lipid in the adipose tissue environment may trigger one such signal. Adipose tissue from obese diabetic db/db mice, high fat diet-fed mice, and obese diabetic patients showed significantly elevated fetuin-A (FetA) levels in respect to their controls; partially hepatectomized high fat diet mice did not show noticeable alteration, indicating adipose tissue to be the source of this alteration. In adipocytes, fatty acid induces FetA gene and protein expressions, resulting in its copious release. We found that FetA could act as a chemoattractant for macrophages. To simulate lipid-induced inflammatory conditions when proinflammatory adipose tissue and macrophages create a niche of an altered microenvironment, we set up a transculture system of macrophages and adipocytes; the addition of fatty acid to adipocytes released FetA into the medium, which polarized M2 macrophages to M1. This was further confirmed by direct FetA addition to macrophages. Taken together, lipid-induced FetA from adipocytes is an efficient chemokine for macrophage migration and polarization. These findings open a new dimension for understanding obesity-induced inflammation

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, “Difficulty falling or staying asleep?” (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with VA and Medicare administrative data and VA fee-for-service data. Those with baseline CVD were excluded. Results: HIV-infected (N=3,108) veterans had a median follow-up time of 10.8 years, during which 267 CVD events occurred. Compared to HIV-infected veterans with no difficulty falling or staying asleep, HIV-infected veterans bothered a lot by insomnia symptoms had an increased risk of incident CVD after adjusting for demographics (HR=1.64, 95%CI=1.16-2.31, p=.005), CVD risk factors (HR=1.62, 95%CI=1.14-2.30, p=.007), additional potential confounders (hepatitis C infection, renal disease, anemia, alcohol use, cocaine use; HR=1.70, 95%CI=1.19-2.43, p=.003), and HIV-specific factors (HIV-1 RNA, CD4+ T-cell count, ART; HR=1.66, 95%CI=1.16-2.37, p=.005). Additional adjustment for non-benzodiazepine sleep medication (HR=1.62, 95%CI=1.13-2.32, p=.009) did not attenuate the association; however, it fell short of significance at p < .01 after adjustment for depressive symptoms (HR=1.51, 95%CI=0.98-2.32, p=.060) or antidepressant medication (HR=1.51, 95%CI=1.04-2.19, p=.031). Conclusion: Highly bothersome insomnia symptoms were significantly associated with incident CVD in HIV-infected veterans, suggesting that insomnia may be a novel, modifiable risk factor for CVD in HIV

Observation of multiple doubly degenerate bands in Tl-195

The High-spin states in 195Tl, populated through the 185,187Re(13C, xn) fusion evaporation reaction at the beam energy of 75 MeV, were studied using the Indian National Gamma Array (INGA). More than 50 new γ transitions have been placed in the proposed level scheme which is extended up to the excitation energy of ≈ 5.6 MeV and spin. Two pairs of degenerate bands based on two different quasi-particle configurations have been identified in this nucleus indicating the first observation of such bands in an odd-A nucleus in region and signify the first evidence of multiple chiral bands in a nucleus in this region. The total Routhian surface calculations predict triaxial shapes for both the configurations and thereby, support the experimental observation. The importance of multiple neutron holes in the orbital and the stability of shapes for these two configurations have been discussed.Financial support of Department of Science & Technology, Govt. of India for clover detectors of INGA (Grant No. IR/S2/PF-03/2003-II) is greatfully acknowledged. One of the authors (S. Bhattacharya) acknowledges with thanks the financial support received as Raja Ramanna Fellowship from the Department of Atomic Energy, Govt. of India. T.R and Md. A.A acknowledge with thanks the financial support received as research fellows from the Department of Atomic Energy (DAE), Govt. of India

New high precision study on the decay width of the Hoyle state in C-12

Precise estimation of the rare direct 3α decay of the Hoyle state of 12C has been made to unveil its unusual α-cluster configurations ranging from linear 3α chain structure to diffuse Bose gas as well as Bose Einstein condensate. The present new high precision, nearly zero background experimental study with Hoyle events has converged on the upper limit for direct decay at ∼0.019% with 95% confidence limit, which is more than a factor of 2 lower than the limit obtained in the previous studies.Two of the authors (S.B. and A.R.) acknowledge the financial support received as Raja Ramanna Fellowship from the Department of Atomic Energy, Government of India

‘Sensory pad’: a novel chemoreceptive device in Hilsa (Tenualosa ilisha) to support its amphihaline attribute

Hilsa, Tenualosa ilisha is an amphihaline migratory fish that performs spawning migration to selected freshwater rivers in Indo-Pacific region. It is not clear what force triggers its migration. In this paper, we attempted to describe the features of outer integument from its head region as chemosensory site which appears to play significant role in its upstream migration. We found that this area (termed as snout) has very soft and scale less tissue oriented with pit like grooves named as ‘epidermal pit’. Around these pits, odorant receptor G-protein subunits (Gαq, Gαs/olf and Gαo) have been substantially localized. Use of DASPEI also traced this area with neuronal existence. These features in the snout likely to contribute for chemosensory requirements of the fish during upstream migration. Considering such findings, we named this area of snout as ‘sensory pad’. Its position at the forefront of olfactory organ and brain may have important role in facilitating sensory reception by the fish swimming upstream to the river