4 research outputs found
Design, synthesis and characterization of novel fluorinated styryl chromones
225-228(E)-3-(3-(Trifluoromethyl)-5-nitrophenyl)acrylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with acetic acid in HCl gives 5. The structures of all synthesized compounds have been confirmed by spectroscopic techniques
Synthesis of novel fluorine containing imidazolyl aurones and benzofurans
1243-1247Imidazolyl aldehyde 1 on reaction with substituted 2-hydroxyacetophenone 2 gives chalcone 3, which on treatment with mercuric acetate in dry pyridine gives compound 4 and when treated with dry acetone in K2CO3 with 4-bromophenacylbromide gives compound 5. The structures of all the synthesized compounds have been confirmed by spectroscopic techniques
Synthesis, characterization and antibacterial screening of fluorinated benzofuran containing heterocycles
504-5102-(4-Fluorophenyl)-5-phenylbenzofuran-3-carboxylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with different reagents Ac2O in presence of sodium acetate, acetic acid in HCl, and hydrazinehydrate in alcohol gives 5, 6 and 7 respectively. The structures of all synthesized compounds have been confirmed by spectroscopic techniques. All the synthesized compounds have been screened for their antibacterial activity
Design, synthesis and characterization of novel fluorinated styryl chromones
(E)-3-(3-(Trifluoromethyl)-5-nitrophenyl)acrylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with acetic acid in HCl gives 5. The structures of all synthesized compounds have been confirmed by spectroscopic techniques