cis-Diammine(glycolato-κ2 O 1,O 2)platinum(II)

The reaction of cis-[Pt(NO3)2(NH3)2] and sodium glycolate yielded the title compound, [Pt(C2H2O3)(NH3)2]. The PtII atom, coordinated by two N atoms of ammine and two O atoms of the carboxyl­ate and oxido groups of the glycolate ligand, is in a square-planar environment. In the crystal structure, mol­ecules are connected by inter­molecular N—H⋯O hydrogen bonds, forming a three-dimensional network

Effects of temperature and wavelength choice on in-situ dissolution test of Cimetidine tablets

AbstractThe effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)<1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of λmax (218nm) was replaced by 244nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature (37°C) with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets

Few-shot image classification with multi-facet prototypes

The aim of few-shot learning (FSL) is to learn how to recognize image categories from a small number of training examples. A central challenge is that the available training examples are normally insufficient to determine which visual features are most characteristic of the considered categories. To address this challenge, we organise these visual features into facets, which intuitively group features of the same kind (e.g. features that are relevant to shape, colour, or texture). This is motivated from the assumption that (i) the importance of each facet differs from category to category and (ii) it is possible to predict facet importance from a pre-trained embedding of the category names. In particular, we propose an adaptive similarity measure, relying on predicted facet importance weights for a given set of categories. This measure can be used in combination with a wide array of existing metric-based methods

Constraints on the cosmological parameters with three-parameter correlation of Gamma-ray bursts

As one of the most energetic and brightest events, gamma-ray bursts (GRBs) can be treated as a promising probe of the high-redshift universe. Similar to type Ia supernovae (SNe Ia), GRBs with same physical origin could be treated as standard candles. We select GRB samples with the same physical origin, which are divided into two groups. One group is consisted of 31 GRBs with a plateau phase feature of a constant luminosity followed by a decay index of about -2 in the X-ray afterglow light curves, and the other has 50 GRBs with a shallow decay phase in the optical light curves. For the selected GRB samples, we confirm that there is a tight correlation between the plateau luminosity $L_0$, the end time of plateau $t_b$ and the isotropic energy release $E_{\gamma,iso}$. We also find that the $L_0-t_b-E_{\gamma,iso}$ correlation is insensitive to the cosmological parameters and no valid limitations on the cosmological parameters can be obtained using this correlation. We explore a new three-parameter correlation $L_0$, $t_b$, and the spectral peak energy in the rest frame $E_{p,i}$ ($L_0-t_b-E_{p,i}$), and find that this correlation can be used as a standard candle to constrain the cosmological parameters. By employing the optical sample only, we find the constraints of $\Omega_m = 0.697_{-0.278}^{+0.402}(1\sigma)$ for a flat $\Lambda$CDM model. For the non-flat $\Lambda$CDM model, the best-fitting results are $\Omega_m = 0.713_{-0.278}^{+0.346}$, $\Omega_{\Lambda} = 0.981_{-0.580}^{+0.379}(1\sigma)$. For the combination of the X-ray and optical smaples, we find $\Omega_m = 0.313_{-0.125}^{+0.179}(1\sigma)$ for a flat $\Lambda$CDM model, and $\Omega_m = 0.344_{-0.112}^{+0.176}$, $\Omega_{\Lambda} = 0.770_{-0.416}^{+0.366}(1\sigma)$ for a non-flat $\Lambda$CDM model.Comment: Accepted for publication in The Astrophysical Journal, 13 pages, 9 figures and 2 table

Assessment of changes in lipid profile and related enzymes in children with asthma

Purpose: To investigate the influence of the lipid profile and related parameters on the development of asthma in children aged 10 to 15 years.Methods: Peripheral blood samples were collected from a group diagnosed with asthma as well as from a healthy control group. The lipid profile parameters measured were total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), high-density lipoprotein (HDL), serum total antioxidant capacity (TAC), reduced glutathione (GSH), and malondialdehyde (MDA), and the activities of lecithin–cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP).Results: TC, TG, LDL, and VLDL levels were significantly (p ≤ 0.05) higher in the asthma group compared with the controls, while HDL level was lower. Total TAC and GSH were lower in the asthma group, while MDA level, and LCAT and CETP activities were higher.Conclusion: There is a link between an elevated lipid profile and increased antioxidant capacity in asthmatic children

Phase I Trial of Escalating-dose Cisplatin with 5-fluorouracil and Concurrent Radiotherapy in Chinese Patients with Esophageal Cancer

We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m2 on day 1, and 5-FU 500 mg/m2 on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m2 with 5-FU 700 mg/m2 and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m2 with 5-FU 700 mg/m2 and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m2 on day 1 and 5FU 700 mg/m2 on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing.</p

Radio Plateaus in Gamma-Ray Burst Afterglows and Their Application in Cosmology

The plateau phase in the radio afterglows has been observed in very few gamma-ray bursts (GRBs), and 27 radio light curves with plateau phase were acquired from the published literature in this article. We obtain the related parameters of the radio plateau, such as temporal indexes during the plateau phase ($\alpha_1$ and $\alpha_2$), break time (\Tbz) and the corresponding radio flux ($F_{\rm b}$). The two parameter Dainotti relation between the break time of the plateau and the corresponding break luminosity (\Lbz) in radio band is \Lbz \propto \Tbz^{-1.20\pm0.24}. Including the isotropic energy \Eiso and the peak energy \Epi, the three parameter correlations for the radio plateaus are written as \Lbz \propto \Tbz^{-1.01 \pm 0.24} \Eiso^{0.18 \pm 0.09} and \Lbz \propto \Tbz^{-1.18 \pm 0.27} \Epi^{0.05 \pm 0.28}, respectively. The correlations are less consistent with that of X-ray and optical plateaus, implying that radio plateaus may have a different physical mechanism. The typical frequencies crossing the observational band may be a reasonable hypothesis that causes the breaks of the radio afterglows. We calibrate GRBs empirical luminosity correlations as standard candle for constraining cosmological parameters, and find that our samples can constrain the flat $\Lambda$CDM model well, while are not sensitive to non-flat ${\Lambda}$CDM model. By combining GRBs with other probes, such as SN and CMB, the constraints on cosmological parameters are \om = 0.297\pm0.006 for the flat ${\Lambda}$CDM model and \om = 0.283\pm0.008, \oL = 0.711\pm0.006 for the non-flat ${\Lambda}$CDM model, respectively.Comment: 16 pages, 6 figures and 6 tables, accepted for publication in Ap