Protein deficiency in spaced-fed rats

1. Adult rats were trained to consume the entire day's ration in 2 h. They showed marked difference in food intake when a diet lacking in protein was given. Two broad stages were observed, the first phase did not show any drop in calorie intake whereas the second showed distinct severe calorie deficiency. 2. Definite changes were noted in the metabolic profiles of the protein-deficient group even though no evidence for a fall in calorie intake (stage 1) was provided by the measurements of body and organ weights, urinary end-products, liver constituents and liver enzymes. 3. The levels of urinary end-products and liver DNA and RNA decreased in the protein deficient and pair-fed control groups compared with the control group. 4. The liver glycogen content remained unchanged in the protein-deficient groups whereas the lipid content and the ratio of vitamin A alcohol to ester increased significantly. 5. The activity of xanthine oxidase in the liver was reduced by 75% in the pair-fed control group and by 95% in the protein-deficient group when compared with the control group. However, the activity of succinic dehydrogenase varied, depending on the unit of activity used to express it

Giant cell tumor of the uterus: case report and response to chemotherapy

BACKGROUND: Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor. The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors. Rarely, GCT can originate at extraosseous sites. More rarely, GCT may exhibit a much more aggressive phenotype. The role of chemotherapy in metastatic GCT is not well defined. CASE PRESENTATION: We report a case of an aggressive GCT of the uterus with rapidly growing lung metastases, and its response to chemotherapy with pegylated-liposomal doxorubicin, ifosfamide, and bevacizumab, along with a review of the literature. CONCLUSION: Aggressive metastasizing GCT may arise in the uterus, and may respond to combination chemotherapy

HIV and Other Sexually Transmitted Infections among Men Who Have Sex with Men Recruited by RDS in Buenos Aires, Argentina: High HIV and HPV Infection

The aim of this study was to estimate the prevalence of HIV and other STIs, among MSM from Buenos Aires (2007-2009).Responding Driven Sampling was used for recruitment of MSM. Participants completed a structured web-based survey and provided biological samples.A total of 496 MSM were studied for HIV, HBV, HCV, and T. pallidum infections. Chlamydia and HPV diagnoses were only performed in 98 and 109 participants, respectively. Prevalence of HIV was 17.3%, HBV 22.9%, HCV 7.5%, T. pallidum 20.5%, HPV 83.5%, and C. trachomatis 1.7%. In the year prior to the evaluation, 71% of the participants had had sex with men and/or trans and women (MMW) while 29% had not had sex with women (MM). Comparing MM to MMW, prevalence of HIV (30.7% vs. 11.9%, p<0.001), HBV (36.4% vs. 17.8%, p<0.001), T. pallidum (32.1% vs. 15.7%, p<0.001), and HPV (88.3% vs. 70.4%, p = 0.039) were significantly higher among MM, whereas no significant differences were found for HCV and C. trachomatis. The MM group had also significantly higher HIV incidence (5.60 vs. 4.28 per 100 persons-year, p = 0.032). HPV genotypes 16, 6, and 11 were the most frequently found; 40.7% of the MSM had more than one genotype and one high risk genotype was detected in 43.6% of participants.Both MM and MMW are at high risk of infection for HIV and other STIs. Rates of HIV, HBV, T. pallidum and HPV infections are higher in the MM group

Dehydro-irradiation process for white pomfret (Stromateus cinereus): synergistic effects of blanching with preservatives, partial dehydration and low dose irradiation

This article does not have an abstract

Development of a radiation process for some Indian fruits: mangoes and sapodillas

A combination heat-radiation process has been evolved for sterilizing mango and sapodilla slices in cans. The fruit, after peeling and slicing, is packed in sanitary cans with sucrose syrup, and the respiratory enzymes are inactivated by heating for 10 min at 70&#176;C. The cans are next evacuated for 6 min at a vacuum of 28 inches Hg, vacuum doubled-seamed, and irradiated with a total dose of 4 &#215; 105 rads at room temperature. Organoleptic evaluation, vitamin retention, and sterility tests show that these processing conditions are optimum and give an acceptable product. Canned mangoes showed progressively lower acceptability with radiation doses above 4 &#215; 105 rads, compared with the thermally processed product. Sapodillas, on the other hand, did not show appreeiable deterioration up to 1.2 &#215; 106 rads

Bacterial studies on irradiated tropical fish-Bombay duck (Harpodon nehereus)

Gamma irradiation (0.4 Mrad) of Bombay duck (Harpodon nehereus) fillets sealed in polyethylene bags brought about alterations in the bacterial flora during storage at 10-12° C. Micrococcus, Pseudomondas, Ackromobacter, Flavobacterium, Microbacterium, Bacillus, Alkaligenes, and Sarcina, which comprised the initial flora of Bombay duck, were predominated by Proteus, Bacillus, Aeromonas, Micro-cocci, and Neisseria in the spoiled samples after four days storage at 10-12° C. In contrast, absence of putrid odors in the irradiated samples stored at 10-12° C for 14 days may be attributed to the biochemically inactive nature of the predominating Micrococci

Radiation preservation of tropical shrimp for ambient temperature storage. 2. Storage studies

This article does not have an abstract

Radiation induced alterations in the endotoxin of S. typhimurium

The lipopolysaccharide (LPS) of S. typhimurium has been shown to be significantly detoxified after in vivo irradiation at 500 krad. Radiation is thus a useful method for converting endotoxin into toxoid. The structural alterations in the detoxified LPS are shown to be mainly in the lipid A molecule, resulting in the loss of &#946;-hydroxymyristic acid