D=10 super-D9-brane

Superfield equations of motion for D=10 type IIB Dirichlet super-9-brane are obtained from the generalized action principle. The geometric equations containing fermionic superembedding equations and constraints on the generalized field strength of Abelian gauge field are separated from the proper dynamical equations and are found to contain these dynamical equations among their consequences. The set of superfield equations thus obtained involves a Spin(1,9) group valued superfield h_\a^{~\b} whose leading component appears in the recently obtained simplified expression for the kappa-symmetry projector of the D9-brane. The Cayley image of this superfield coincides (on the mass shell) with the field strength tensor of the world volume gauge field characteristic for the Dirichlet brane. The superfield description of the super-9-brane obtained in this manner is known to be, on the one hand, the nonlinear (Born-Infeld) generalization of supersymmetric Yang-Mills theory and, on the other hand, the theory of partial spontaneous breaking of D=10, N=IIB supersymmetry down to D=10, N=1.Comment: 34 pages, LATEX. Minor corrections. References adde

Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways

The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, cholesterol-rich domains of the plasma membrane, termed caveolae due to their invaginated shape. The structural protein caveolin-1 partly accounts for anchoring of these receptors. We here determined the role of the other major caveolar protein, caveolin-3 (cav-3), in orchestrating cholinergic and serotonergic ASM responses, utilizing newly generated cav-3 deficient mice. Cav-3 deficiency fully abrogated serotonin-induced constriction of extrapulmonary airways in organ baths while leaving intrapulmonary airways unaffected, as assessed in precision cut lung slices. The selective expression of cav-3 in tracheal, but not intrapulmonary bronchial epithelial cells, revealed by immunohistochemistry, might explain the differential effects of cav-3 deficiency on serotonergic ASM constriction. The cholinergic response of extrapulmonary airways was not altered, whereas a considerable increase was observed in cav-3â -/- intrapulmonary bronchi. Thus, cav-3 differentially organizes serotonergic and cholinergic signaling in ASM through mechanisms that are specific for airways of certain caliber and anatomical position. This may allow for selective and site-specific intervention in hyperreactive states

Universal conservation law and modified Noether symmetry in 2d models of gravity with matter

It is well-known that all 2d models of gravity---including theories with nonvanishing torsion and dilaton theories---can be solved exactly, if matter interactions are absent. An absolutely (in space and time) conserved quantity determines the global classification of all (classical) solutions. For the special case of spherically reduced Einstein gravity it coincides with the mass in the Schwarzschild solution. The corresponding Noether symmetry has been derived previously by P. Widerin and one of the authors (W.K.) for a specific 2d model with nonvanishing torsion. In the present paper this is generalized to all covariant 2d theories, including interactions with matter. The related Noether-like symmetry differs from the usual one. The parameters for the symmetry transformation of the geometric part and those of the matterfields are distinct. The total conservation law (a zero-form current) results from a two stage argument which also involves a consistency condition expressed by the conservation of a one-form matter ``current''. The black hole is treated as a special case.Comment: 3

Hepatoprotective Effects of Milk Thistle (Silybum marianum) Seed Cakes during the Chicken Broiler Fattening

The objective of this work was to verify the hepatoprotective effects of Silybum marianum seed cakes in feed mixtures used for the fattening of chicken broilers to heavier weights. Part of the experiment was to verify the preventive effect of such modified feed mixtures with the use of chlortetracycline medication. The experiment was carried out on 180 ROSS 308 broiler chickens. The chickens were fed complete feed mixtures containing 0.0% (K), 0.2% (P1 and 1.0% (P2) of Silybum marianum seed cakes. The cakes used contained 2.95% of silymarin. On the 44th day of fattening half of the chickens from every group were supplied with chlortetracycline medicated water at a dose of 2 g kg1 live weight. The selected biochemical indices were observed: cholesterol (Chol), glutamyl transferase (GMT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). On the 52nd day of the test, six chickens from each group were euthanized and their liver was taken for histological examination. Adding Silybum marianum seed cakes resulted in a non-significant decrease in the chickens' live weight and in the feed conversion in both experimental groups compared to the control group. The cholesterol levels were highly significantly lower (p p p p p p p < 0.01) the content of lipids and increased the content of glycogen in the liver of both experimental groups

A Large Web-Based Observer Reliability Study of Early Ischaemic Signs on Computed Tomography. The Acute Cerebral CT Evaluation of Stroke Study (ACCESS)

BACKGROUND: Early signs of ischaemic stroke on computerised tomography (CT) scanning are subtle but CT is the most widely available diagnostic test for stroke. Scoring methods that code for the extent of brain ischaemia may improve stroke diagnosis and quantification of the impact of ischaemia. METHODOLOGY AND PRINCIPAL FINDINGS: We showed CT scans from patients with acute ischaemic stroke (n = 32, with different patient characteristics and ischaemia signs) to doctors in stroke-related specialties world-wide over the web. CT scans were shown twice, randomly and blindly. Observers entered their scan readings, including early ischaemic signs by three scoring methods, into the web database. We compared observers' scorings to a reference standard neuroradiologist using area under receiver operator characteristic curve (AUC) analysis, Cronbach's alpha and logistic regression to determine the effect of scales, patient, scan and observer variables on detection of early ischaemic changes. Amongst 258 readers representing 33 nationalities and six specialties, the AUCs comparing readers with the reference standard detection of ischaemic signs were similar for all scales and both occasions. Being a neuroradiologist, slower scan reading, more pronounced ischaemic signs and later time to CT all improved detection of early ischaemic signs and agreement on the rating scales. Scan quality, stroke severity and number of years of training did not affect agreement. CONCLUSIONS: Large-scale observer reliability studies are possible using web-based tools and inform routine practice. Slower scan reading and use of CT infarct rating scales improve detection of acute ischaemic signs and should be encouraged to improve stroke diagnosis

Two-dimensional effective action for matter fields coupled to the dilaton

We revise the calculation of the one-loop effective action for scalar and spinor fields coupled to the dilaton in two dimensions. Applying the method of covariant perturbation theory for the heat kernel we derive the effective action in an explicitly covariant form that produces both the conformally invariant and the conformally anomalous terms.For scalar fields the conformally invariant part of the action is nonlocal. The obtained effective action is proved to be infrared finite. We also compute the one-loop effective action for scalar fields at finite temperature.Comment: LaTeX, 25 page

Cyclotron resonance of extremely conductive 2D holes in high Ge content strained heterostructures

Cyclotron resonance has been observed in steady and pulsed magnetic fields from high conductivity holes in Ge quantum wells. The resonance positions, splittings and linewidths are compared to calculations of the hole Landau levels

From the Birkhoff-Gustavson normalization to the Bertrand-Darboux integrability condition

The Bertrand-Darboux integrability condition for a certain class of perturbed harmonic oscillators is studied from the viewpoint of the Birkhoff-Gustavson(BG)-normalization: By solving an inverse problem of the BG-normalization on computer algebra, it is shown that if the perturbed harmonic oscillators with a homogeneous-{\it cubic} polynomial potential and with a homogeneous-{\it quartic} polynomial potentials admit the same BG-normalization up to degree-4 then both oscillators satisfy the Bertrand-Darboux integrability condition.Comment: 23 pages, LaTeX (iop.sty), typos and Appendix adde