Type IV Radio Bursts and Associated Active Regions in Sunspot Cycle 24

We study the association of solar Type IV radio bursts with the location of active regions on the Sun during Solar Cycle 24. The active regions associated with moving and stationary Type IV bursts are categorized as close to disk center and far from disk center, based on their location on the solar surface (i.e. ≤ 45◦ or ≥ 45◦, respectively). The location of active regions associated with Type IV bursts accompanied with coronal mass ejections (CMEs) are also studied. We found that ≈ 30 – 40% of the active regions are located far from disk center for all the bursts. However, it is found that most of the active regions associated with stationary Type IV bursts are close to disk center (≈ 60 – 70%). The active regions associated with moving Type IV bursts are more evenly distributed across the surface, i.e. ≈ 56% and ≈ 44%, close to disk center and far from disk center, respectively. The fact that most of the bursts have active regions close to disk center indicates that these bursts can be used to obtain physical properties such as electron density and magnetic fields of the CMEs responsible for geomagnetic storms.Peer reviewe

Changes in microRNA target sites attributed to single nucleotide polymorphisms may influence breast cancer susceptibility

MicroRNAs (miRNAs) are a class of small, ~22-nt-long endogenous, single-stranded non-coding RNAs (ncRNAs) that takes part in post-transcriptional gene silencing through deadenylation, translational repression, and destroying their target messenger RNAs (mRNAs) They exert their regulatory role on the corresponding mRNAs by binding to their 3’UTR, CDS and 5’UTR. When SNP occurs in 3’ UTRs, it changes the mRNA stability and translation by altering the miRNA::mRNA interactions. SNPs present in the 3’UTR of genes associated with breast cancer might contribute to the initiation and susceptibility of the malignancy. In this work, we aim to find the significant pairs of target SNP:miRNA by using the different in silico methods. From our analysis, we screened and got six potential target SNP pairs which have been proposed to be involved in breast cancer risk in females

On the occurrence of type IV solar radio bursts in the solar cycle 24 and their association with coronal mass ejections

Solar activities, in particular coronal mass ejections (CMEs), are often accompanied by bursts of radiation at metre wavelengths. Some of these bursts have a long duration and extend over a wide frequency band, namely, type IV radio bursts. However, the association of type IV bursts with coronal mass ejections is still not well understood. In this article, we perform the first statistical study of type IV solar radio bursts in the solar cycle 24. Our study includes a total of 446 type IV radio bursts that occurred during this cycle. Our results show that a clear majority,∼81% of type IV bursts, were accompanied by CMEs, based on a temporal association with white-light CME observations. However,we found that only∼2.2% of the CMEs are accompanied by type IV radio bursts. We categorised the type IV bursts as moving or stationary based on their spectral characteristics and found that only∼18% of the total type IV bursts in this study were moving type IV bursts. Our study suggests that type IV bursts can occur with both ‘Fast’ (≥500 km/s) and ‘Slow’ (<500 km/s), and also both ‘Wide’(≥60◦) and ‘Narrow’ (<60◦) CMEs. However, the moving type IV bursts in our study were mostly associated with ‘Fast’ and ‘Wide’ CMEs (∼52%), similar to type II radio bursts. Contrary to type II bursts, stationary type IV bursts have a more uniform association with all CME types.Peer reviewe

Solar Coronal Density Turbulence and Magnetic Field Strength at the Source Regions of Two Successive Metric Type II Radio Bursts

We report spectral and polarimeter observations of two weak, low-frequency (≈85–60 MHz) solar coronal type II radio bursts that occurred on 2020 May 29 within a time interval ≈2 minutes. The bursts had fine structures, and were due to harmonic plasma emission. Our analysis indicates that the magnetohydrodynamic shocks responsible for the first and second type II bursts were generated by the leading edge (LE) of an extreme-ultraviolet flux rope/coronal mass ejection (CME) and interaction of its flank with a neighboring coronal structure, respectively. The CME deflected from the radial direction by ≈25° during propagation in the near-Sun corona. The estimated power spectral density and magnetic field strength (B) near the location of the first burst at heliocentric distance r ≈ 1.35 Re are ≈2 × 10−3 W2m and ≈1.8 G, respectively. The corresponding values for the second burst at the same r are ≈10−3 W2 m and ≈0.9 G. The significant spatial scales of the coronal turbulence at the location of the two type II bursts are ≈62–1 Mm. Our conclusions from the present work are that the turbulence and magnetic field strength in the coronal region near the CME LE are higher compared to the corresponding values close to its flank. The derived estimates of the two parameters correspond to the same r for both the CME LE and its flank, with a delay of ≈2 minutes for the latter.Peer reviewe

Artificial Intelligence approach to verify irrationality of FDCs listed by CDSCO

Various Artificial Intelligence (AI) tools were utilized to verify the irrationality of Fixed-Dose-Combinations (FDCs) which were already proven irrational by CDSCO. SwissADME, one of the AI tools was able to generate properties of FDCs by using two-dimensional structures downloaded from Pubchem (a free data source). Another interesting finding was obtained by using two different AI tools ChatGPT and BARD. These AI tools identified uncommon comparative properties and predicted most of the FDCs are irrational. This suggests that these AI tools can play a crucial role in identifying irrationality in drugs. Additionally, the study looked into drug–drug interactions, and it was found that most of the FDCs are exhibited such interactions. AI tools were capable of analysing the irrationality of a significant number of drugs. However, SwissADME, one of the AI tools has limited capability in processing large structures. This proves the further need for improvements in AI technology to produce more accurate and comprehensive analyses

Comparative study of pharmacological and combined pharmaco-mechanical method of induction of labour: a randomised study

Background: Comparative study of Pharmacological and Pharmaco- Mechanical method of induction of labour- A Randomised study. The objective of the study was to compare efficacy of pharmacological and combined pharmaco-mechanical method of induction of labour.Methods: A study was conducted in the department of Obstetrics and gynaecology, Adichunchanagiri Institute of Medical Sciences and Research Centre for a period of 18 months. 200 pregnant women requiring induction of labour were included in the study.  In group 1 Dinoprostone 0.5 mg gel was inserted into cervical canal. In group 2 Foley’s catheter No 18 F was inserted within the cervix. The balloon of the catheter was filled with 30 ml normal saline and at the same time Dinoprostone 0.5 mg gel was inserted into posterior vaginal fornix. The Excel and SPSS (SPSS Inc, Chicago V 18.5) software packages were used for data entry and analysis. The results were averaged (mean ± Std Deviation) for each parameter for continuous data in tables.Results: Mean induction to active phase interval in group 1 was 8.43±4.11 hrs, in group 26.82±3.01 hrs (p =0.001). The rate of vaginal delivery in group 1 and group 2 was 55% and 66% respectively, difference was statistically significant (p=0.026).Conclusions: Synchronous use of intracervical Foley’s catheter and Dinoprostone 0.5 mg resulted in a shorter time for progress to active phase and also shortened induction to delivery interval as compared to Dinoprostone 0.5 mg alone. Higher risk of caesarean delivery was associated with single method as compared to combined methods.

Type II radio bursts and their association with coronal mass ejections in solar cycles 23 and 24

Metre wavelength type II solar radio bursts are believed to be the signatures of shock-accelerated electrons in the corona. Studying these bursts can give information about the initial kinematics, dynamics and energetics of CMEs in the absence of white-light observations. In this study, we investigate the occurrence of type II bursts in solar cycles 23 and 24 and their association with coronal mass ejections (CMEs). We also explore the possibility of occurrence of type II bursts in the absence of a CME. We performed statistical analysis of type II bursts that occurred between 200 - 25 MHz in solar cycle 23 and 24 and found the temporal association of these radio bursts with CMEs. We categorised the CMEs based on their linear speed and angular width, and studied the distribution of type II bursts with `fast' ($speed ~\geq 500 km/s$), `slow' ($speed ~< 500 km/s$), `wide' ($width ~\geq 60^o$) and `narrow' ($width ~< 60^o$) CMEs. We explored the type II bursts occurrence dependency with solar cycle phases. Our results suggest that type II bursts dominate at heights $\approx 1.7 - 2.3 \pm 0.3 ~R_{\odot}$ with a clear majority having an onset height around 1.7 $\pm 0.3~R_{\odot}$ assuming the four-fold Newkirk model. The results indicate that most of the type II bursts had a white-light CME counterpart, however there were a few type II which did not have a clear CME association. There were more CMEs in cycle 24 than cycle 24. However, the number of type II radio bursts were less in cycle 24 compared to cycle 23. The onset heights of type IIs and their association with wide CMEs reported in this study indicate that the early CME lateral expansion may play a key role in the generation of these radio bursts.Comment: 17 pages, 8 figures, 4 tables, Accepted for publication in Astronomy & Astrophysic

Broadcast, Trace and Revoke with Optimal Parameters from Polynomial Hardness

A broadcast, trace and revoke system generalizes broadcast encryption as well as traitor tracing. In such a scheme, an encryptor can specify a list $L \subseteq N$ of revoked users so that (i) users in $L$ can no longer decrypt ciphertexts, (ii) ciphertext size is independent of $L$, (iii) a pirate decryption box supports tracing of compromised users. The ``holy grail\u27\u27 of this line of work is a construction which resists unbounded collusions, achieves all parameters (including public and secret key) sizes independent of $|L|$ and $|N|$, and is based on polynomial hardness assumptions. In this work we make the following contributions: 1. Public Trace Setting: We provide a construction which (i) achieves optimal parameters, (ii) supports embedding identities (from an exponential space) in user secret keys, (iii) relies on polynomial hardness assumptions, namely compact functional encryption (${\sf FE}$) and a key-policy attribute based encryption (${\sf ABE}$) with special efficiency properties, and (iv) enjoys adaptive security with respect to the revocation list. The previous best known construction by Nishimaki, Wichs and Zhandry (Eurocrypt 2016) which achieved optimal parameters and embedded identities, relied on indistinguishability obfuscation, which is considered an inherently subexponential assumption and achieved only selective security with respect to the revocation list. 2. Secret Trace Setting: We provide the first construction with optimal ciphertext, public and secret key sizes and embedded identities from any assumption outside Obfustopia. In detail, our construction relies on Lockable Obfuscation which can be constructed using ${\sf LWE}$ (Goyal, Koppula, Waters and Wichs, Zirdelis, Focs 2017) and two ${\sf ABE}$ schemes: (i) the key-policy scheme with special efficiency properties by Boneh et al. (Eurocrypt 2014) and (ii) a ciphertext-policy ${\sf ABE}$ for ${\sf P}$ which was recently constructed by Wee (Eurocrypt 2022) using a new assumption called {\it evasive and tensor} ${\sf LWE}$. This assumption, introduced to build an ${\sf ABE}$, is believed to be much weaker than lattice based assumptions underlying ${\sf FE}$ or ${\sf iO}$ -- in particular it is required even for lattice based broadcast, without trace. Moreover, by relying on subexponential security of ${\sf LWE}$, both our constructions can also support a super-polynomial sized revocation list, so long as it allows efficient representation and membership testing. Ours is the first work to achieve this, to the best of our knowledge