Synthesis, characterization and antimicrobial investigation of Rh(III), Ru(III) and Ag(I) complexes with some derivatives of 3-amino-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones

The reaction of 2,3-disubstituted mercapto quinazolines with 2-hydroxy benzaldehyde (HBAMQ) (1), 2-hydroxy naphthaldehyde (HNAMQ) (2), pyridine-2-carboxaldehyde (PMAMQ) (3) and thiophen-2-carboxaldehyde (TMAMQ) (4), and with metals like Rh(III), Ru(III), and Ag(I) in the presence of piperidine resulted in the formation of their respective complexes by physicochemical methods. The newly synthesized complexes were characterized by elemental analysis, magnetic data, and spectroscopic techniques like UV-Visible, IR and 1H NMR, respectively. These compounds were also evaluated for their antimicrobial activities

One-pot synthesis of novel 1,2,3-triazole-pyrimido[4,5-c]isoquinoline hybrids and evaluation of their antioxidant activity

<p>A series of novel pyrimido[4,5-<i>c</i>]isoquinolines (<b>3a–3h</b>) and 1,2,3-triazole-coupled pyrimido[4,5-<i>c</i>]isoquinolines (<b>4a–4h</b>) were synthesized in good to excellent yields in the one-pot method. The reaction of 6-amino-1,3-dimethyluracil with different 2-iodo benzoyl chlorides using Pd catalyst in dimethylformamide afforded corresponding pyrimido[4,5-<i>c</i>]isoquinolines (<b>3a–3h</b>). One-pot reaction of pyrimido[4,5-<i>c</i>]isoquinolines with propargyl bromide and benzyl azide in THF at room temperature furnished 1,2,3-triazole-coupled pyrimido[4,5-<i>c</i>]isoquinoline (<b>4a–4h</b>). In vitro antioxidant activity examination revealed that compounds <b>4d</b> and <b>4c</b> found to exhibit potent antioxidant activity as compared to the standard drug Trolox with IC₅₀ values 6.02 ± 0.6 and 12.18 ± 0.9 µM, respectively.</p