Aripiprazole loaded PLGA nanoparticles for controlled release studies: Effect of Co-polymer ratio

Poly (lactic-co-glycolic acid) nanoparticles loaded with Aripiprazole has been developed as a new therapeutic strategy to achieve its controlled release profile suitable for parenteral administration. Nanospheres composed of different lactic/glycolic acid ratios and drug compositions were synthesized and loaded with Aripiprazole by emulsion/solvent evaporation method and subsequently characterized by particle-size distribution, scanning electron microscopy, encapsulation efficiency and in–vitro drug release studies. Specific drug-polymer interactions are engineered by optimizing the lactide to glycolide ratio (L:G ratio) and including specific polymer hydrophobicity

Aripiprazole loaded PLGA nanoparticles for controlled release studies: Effect of Co-polymer ratio

Poly (lactic-co-glycolic acid) nanoparticles loaded with Aripiprazole has been developed as a new therapeutic strategy to achieve its controlled release profile suitable for parenteral administration. Nanospheres composed of different lactic/glycolic acid ratios and drug compositions were synthesized and loaded with Aripiprazole by emulsion/solvent evaporation method and subsequently characterized by particle-size distribution, scanning electron microscopy, encapsulation efficiency and in–vitro drug release studies. Specific drug-polymer interactions are engineered by optimizing the lactide to glycolide ratio (L:G ratio) and including specific polymer hydrophobicity

DEVELOPMENT AND CHARACTERIZATION OF POLYCAPROLACTONE (PCL)/POLY ((R)-3-HYDROXYBUTYRIC ACID) (PHB) BLEND MICROSPHERES FOR TAMOXIFEN DRUG RELESE STUDIES

Objective: The objective of this study was to formulate and evaluate the drug release studies using Poly (ε-caprolactone) (PCL)/and Poly (R)-3-hydroxy butyric acid (PHB) blend microspheres for controlled release of Tamoxifen, an anticancer drug.Methods: Poly (ε-caprolactone), Poly ((R)-3-Hydroxybutyric acid) blend microspheres were prepared through a modified Water/Oil/Water (W/O/W) double emulsion-solvent diffusion method using Dichloromethane as solvent. Tamoxifen (TAM), an anti Cancer drug, was used for encapsulation within PCL/PHB blend microspheres. Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated by different characterization techniques such as Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry(DSC), Scanning electron microscopy(SEM), X-ray diffraction studies(X-RD) and dissolution test studies respectively.Results: Drug loaded microspheres were analyzed by FT-IR, which indicates the interaction between drug and polymers. DSC thermograms on drug-loaded microspheres confirmed the polymorphism of Tamoxifen and indicated a molecular level dispersion of drug in the microspheres. SEM confirmed the spherical nature and smooth surface of the microspheres produced. X-RD study was performed to understand the crystalline nature of the drug after encapsulation into the microspheres and confirmed the complete dispersion of the drug in the polymer matrix. In-vitro release studies conducted in different pH which indicated a dependence of release rate on the amount of drug loading and the amount of PCL/PHB, but slow release rates were extended up to 12 h. Kinetic analysis of dissolution data showed a good fit in Peppas equation confirming diffusion controlled drug release.Conclusions: The research findings obtained from the studies were found to be satisfactory. It can be concluded that biodegradable polymer blend (PCL/PHB) microspheres can be effectively used for preparation of controlled release matrices. Â

B-flavor tagging at Belle II

We report on new flavor tagging algorithms developed to determine the quark-flavor content of bottom ( ) mesons at Belle II. The algorithms provide essential inputs for measurements of quark-flavor mixing and charge-parity violation. We validate and evaluate the performance of the algorithms using hadronic decays with flavor-specific final states reconstructed in a data set corresponding to an integrated luminosity of 62.8 fb−1 , collected at the resonance with the Belle II detector at the SuperKEKB collider. We measure the total effective tagging efficiency to be εeff=(30.0±1.2(stat)±0.4(syst))% for a category-based algorithm and εeff=(28.8±1.2(stat)±0.4(syst))% for a deep-learning-based algorithm

Search for charged-lepton flavor violation in Υ(2S)→ℓ∓τ±\Upsilon(2S) \to \ell^\mp\tau^\pm (ℓ=e,μ\ell=e,\mu) decays at Belle

We report a search for the charged-lepton flavor violation in $\Upsilon(2S) \to \ell^\mp\tau^\pm$ ($\ell=e,\mu$) decays using a $25~\mathrm{fb}^{-1}$ $\Upsilon(2S)$ sample collected by the Belle detector at the KEKB $e^{+}e^{-}$ asymmetric-energy collider. We find no evidence for a signal and set upper limits on the branching fractions ($\mathcal{B}$) at 90$\%$ confidence level. We obtain the most stringent upper limits: $\mathcal{B}(\Upsilon(2S) \to \mu^{\mp}\tau^{\pm}) < 0.26 \times 10^{-6}$ and $\mathcal{B}(\Upsilon(2S) \to e^{\mp}\tau^{\pm}) < 1.02 \times 10^{-6}$.Comment: 11 pages, 3 figures, Submitted to JHE

Search for B⁰ meson decays into Λ and missing energy with a hadronic tagging method at Belle

We present a search for the decays of B0 mesons into a final state containing a Λ baryon and missing energy. These results are obtained from a 711  fb−1 data sample that contains 772×106  B¯B pairs and was collected near the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e− collider. We use events in which one B meson is fully reconstructed in a hadronic decay mode and require the remainder of the event to consist of only a single Λ. No evidence for these decays is found, and we set 90% confidence level upper limits on the branching fractions in the range 2.1–3.8×10−5. This measurement provides the world’s most restrictive limits, with implications for baryogenesis and dark matter production

Evidence for the singly Cabibbo-suppressed decay Ωc0→Ξ−π+\Omega^0_c\to\Xi^-\pi^+ and search for Ωc0→Ξ−K+\Omega^0_c\to\Xi^-K^+ and Ω−K+\Omega^-K^+ decays at Belle

Using a data sample of 980 fb$^{-1}$ collected with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider, we study for the first time the singly Cabibbo-suppressed decays $\Omega^0_c\to\Xi^{-}\pi^{+}$ and $\Omega^-K^+$ and the doubly Cabibbo-suppressed decay $\Omega^0_c\to \Xi^- K^{+}$. Evidence for an $\Omega^0_c$ signal in the $\Omega^0_c\to\Xi^-\pi^+$ mode is reported with a significance of $4.5\sigma$ including systematic uncertainties. The ratio of branching fractions to the normalization mode $\Omega_c^0\to \Omega^-\pi^+$ is measured to be $${\cal B}(\Omega_{c}^{0} \to \Xi^{-} \pi ^{+} )/{\cal B}(\Omega_c^0\to \Omega^-\pi^+)=0.253\pm 0.053({\rm stat.})\pm 0.030({\rm syst.}).$$ No significant signals of $\Omega^0_c\to\Xi^-K^+$ and $\Omega^-K^+$ modes are found. The upper limits at $90\%$ confidence level on ratios of branching fractions are determined to be $${\cal B}(\Omega_{c}^{0} \to \Xi^{-} K ^{+})/{\cal B}(\Omega_c^0\to \Omega^-\pi^+) < 0.070$$ and $${\cal B}(\Omega_{c}^{0} \to \Omega^{-}K^{+})/{\cal B}(\Omega_c^0\to \Omega^-\pi^+) < 0.29.$$Comment: 11 pages, 2 figure

Search for the lepton flavour violating decays B+→K+τ±ℓ∓B^{+} \to K^{+} \tau^\pm \ell^\mp (ℓ=e,μ\ell = e, \mu) at Belle

We present a search for the lepton-flavour-violating decays $B^+ \to K^+ \tau^\pm \ell^\mp$, with $\ell = (e, \mu)$, using the full data sample of $772 \times 10^6$ $B\overline{B}$ pairs recorded by the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. We use events in which one $B$ meson is fully reconstructed in a hadronic decay mode. We find no evidence for $B^\pm \to K^\pm \tau \ell$ decays and set upper limits on their branching fractions at the 90% confidence level in the $(1$-$3) \times 10^{-5}$ range. The obtained limits are the world's best results.Comment: 14 pages, 6 figure

Evidence for the decay ωc_{c}0^{0} →π+^{+} ω (2012)−^{-} →π+^{+} (K‾\overline{K} Ξ)−^{-}

Using a data sample of 980 fb$^{-1}$ collected with the Belle detector operating at the KEKB asymmetric-energy e$^{+}$e$^{-}$ collider, we present evidence for the Ω(2012)$^{-}$ in the resonant substructure of Ω$_{c}$$^{0}$ → π$^{+}$ ($\overline{K}$ Ξ)$^{-}$ (($\overline{K}$ Ξ)$^{-}$ = K$^{-}$Ξ$^{0}$ + K$^{0}$Ξ$^{-}$ ecays. The significance of the decays. The significance of the Ω(2012)$^{-}$ signal is 4.2σ after considering the systematic uncertainties. The ratio of the branching fraction of Ω$_{c}$$^{0}$ → π$^{+}$ Ω(2012)$^{-}$ π$^{+}$ ($\overline{K}$ Ξ)$^{-}$ relative to that of Ω$_{c}$$^{0}$ → π$^{+}$ Ω$^{-}$ is calculated to be 0.220±0.059(stat.)±0.035(syst.). The individual ratios of the branching fractions of the two isospin modes are also determined and found to be B (Ω$_{c}$$^{0}$ → π$^{+}$ Ω(2012)$^{-}$) x B(Ω(2012)$^{-}$ → $\overline{K}$ Ξ$^{0}$) / B(Ω$_{c}$$^{0}$ → π$^{+}$ K$^{-}$Ξ$^{0}$ = (9.6±3.2(stat.) ±1.8(syst.))% and B (Ω$_{c}$$^{0}$ → π$^{+}$ Ω(2012)$^{-}$) x B(Ω(2012)$^{-}$ → $\overline{K}$$^{0}$ Ξ$^{-}$) / B(Ω$_{c}$$^{0}$ → π$^{+}$ $\overline{K}$$^{0}$Ξ$^{-}$) =(5.5±2.8(stat.) ±0.7(syst.))