Classification of Encryption Algorithms using Fisher’s Discriminant Analysis

Fisher’s Discriminant Analysis (FDA) is a method used in statistics and machine learning which can often lead to good classification between several populations by maximizing the separation between the populations. We will present some applications of FDA that discriminate between cipher texts in terms of a finite set of encryption algorithms. Specifically, we use ten algorithms, five each of stream and block cipher types. Our results display good classification with some of the features. In the present case we have little in terms of an existing standard; however, our limited study clearly shows that further exploration of this issue could be worthwhile

COVID-19: AN APPLIED INTERVENTION THROUGH AYURVEDA

The world is crippling due to pandemic coronavirus disease (COVID-19) which is caused by severe acute respiratory syndrome Coronavirus (SARS-CoV-2). This situation can be considered under Janapadodhwamsa (destructions of states or kingdoms or countries) as mentioned in Ayurveda. Further, COVID-19 infection may be correlated with Vata-Kaphaja Sannipataja Jwara (a type of fever mentioned in classical Ayurvedic texts with severe complications and fatality). The article is mainly intended to interpret direct correlation between pandemics and Janapadodhwamsa, understanding the concept of COVID-19 and its probable management principles based on ethics of Ayurveda. The main aim of management principles includes correction of the Vikruta (contaminated) Vayu (air) and Desha (place/continent etc.) and improving the strength and immunity for prevention of disease as well as the management of COVID 19 patients by various herbal or herbo-mineral combinations based on the stage/severity of the disease along with follow up of recovered patients to avoid the recurrence. Considering above comprehensive aspect in management of COVID-19, the role of Ayurveda intervention may be proved more beneficial in asymptomatic, mild and moderate stages. Further, clinical studies on these drugs need to be conducted to produce evidence for safety and efficacy on COVID-19 for wider acceptance and implementation of Ahara Vidhis, Dinacharya and Sadvritta in National Health Policies for improving disease resistance

Craniovertebral Junction Koch spine – an unusual presentation treated with a novel approach: case report and review of literature

The retropharyngeal space lies in the posterior pharyngeal wall between the middle and deep layers of the deep cervical fascia. It extends from the base of the skull to the mediastinum and frequently serves as a conduit for spread of disease from the neck into the chest. Spinal tuberculosis is the commonest extra pulmonary manifestation of tuberculosis. Clinical findings of cervical tuberculosis includes neck pain, restricted neck movements, quadriparesis, radicular manifestations, kyphosis, and sensory disturbance. It should be suspected in an adult person who presents with a destructive lesion of the cervical vertebra and retro-pharyngeal mass. Early diagnosis and treatment are necessary to prevent the serious complications of the disease. We present here a 46 years old female who presented to a tertiary care setup with acute onset dyspnea and quadriplegia with bladder bowel involvement managed with trans oral incision and drainage of retropharyngeal abscess followed by posterior occipitocervical fusion supplemented with Anti Koch Therapy with a good follow up

Autonomic Dysfunction in Acromegaly: A Case Report

Orthostatic hypotension commonly presents in patients with chronic illnesses like hypertension, diabetes mellitus, chronic kidney disease and LV dysfunction. Autonomic dysfunction is often overlooked as a cause for orthostatic hypotension that can lead to increased morbidity and mortality. Though autonomic dysfunction on electrophysiological testing has been described in patients with acromegaly, symptomatic dysautonomia resulting in orthostatic hypotension has not been previously reported in literature. Here we present a case of acromegaly who presented with postural hypotension. RR variability based clinical tests showed presence of autonomic insufficiency. His symptoms improved with conservative measures

Charcot’s Neuroarthropathy: A Case Report and Review of Literature

Charcot’s neuroarthropathy (CN) is a progressive disabling complication of diabetes mellitus, usually seen 10 years after diagnosis of diabetes. There is widespread destruction of affected joint and bones around it leading to severe deformity and loss of function. Its treatment may require multiple corrective surgeries or even amputation apart from application of cast, glycemic control and bisphosphonates. Here, we report such a case of CN, which was treated with multiple strategies aggressively to a good outcome

Biofield Treatment: An Alternative Approach to Combat Multidrug-Resistant Susceptibility Pattern of Raoultella ornithinolytica

International audienceRaoultella ornithinolytica is belongs to the family of Enterobacteriaceae, a Gram-negative encapsulated aerobic bacillus associated with bacteremia and urinary tract infections. As biofield therapy is increasingly popular in biomedical heath care, so present study aimed to evaluate the impact of Mr. Trivedi’s biofield treatment on antimicrobial sensitivity, minimum inhibitory concentration (MIC), biochemical study, and biotype number of multidrug resistant strain of R. ornithinolytica. Clinical sample of R. ornithinolytica was divided into two groups i.e. control and biofield treated which were analyzed for the above parameters using MicroScan Walk-Away® system on day 10 after treatment. Antimicrobial sensitivity assay results showed a significant increase (60.71%) in sensitivity pattern of antimicrobials i.e. changed from resistant to susceptible while 10.71% of tested antimicrobials changed from intermediate to susceptible as compared to control. MIC results showed a significant decrease in MIC values of 71.88% tested antimicrobials as compared to control.Biochemical reaction study showed 15.15% alteration in different biochemical such as cetrimide, cephalothin, kanamycin, and ornithine after biofield treatment as compared to control. A significant change in biotype number (7775 4370) was also observed with organism identified as Klebsiella oxytoca after biofield treatment as compared to control (7775 5372). Overall results conclude that biofield treatment could be used as complementary and alternative treatment strategy against multidrug resistant strain of R. ornithinolytica with respect to improve the sensitivity and reduce the MIC values of antimicrobials. Hence, it is assumed that biofield treatment might be a suitable cost effective treatment strategy in near future, which could have therapeutic value in patients suffering from multidrug resistant pathogens

Phenotypic and Biotypic Characterization of Klebsiella oxytoca: An Impact of Biofield Treatment

International audienceKlebsiella oxytoca (K. oxytoca) is a Gram-negative microbe generally associated with community and hospital-acquired infections. Due to its clinical significance, we evaluated the effect of biofield treatment on phenotype and biotype characteristics of K. oxytoca (ATCC 43165). The study was performed into three groups i.e. C (control), T1 (treatment, revived); and T2 (treatment, lyophilized). Subsequently, groups T1 and T2 were received biofield treatment and control group was remained as untreated. The antimicrobial sensitivity results showed 3.33% and 6.67% alteration in antimicrobials susceptibility in group T1 cells on day 5 and 10, respectively, and 3.33% alteration in antimicrobials susceptibility was observed in group T2 cells on day 10 as compared to control. The sensitivity patterns of cefazolin were changed from resistant (R) to intermediate (I) on day 5, and resistance (R) to susceptible (S) on day 10, in T1 cells of K. oxytoca. The MIC value of cefazolin was decreased by 2-fold in group T1 on day 10 as compared to control. The biofield treated K. oxytoca exhibited the changes in biochemical reactions about 3.03% and 15.15% of total tested biochemicals in group T1 cells on day 5 and 10, respectively as compared to control. The biotype number of K. oxytoca was altered in biofield treated group and organism identified as Raoultella ornithinolytica in T1 on day 10 as compared to control, which is the prominent finding of this study. These changes were found in treated bacteria that might be due to some alteration happened in metabolic/enzymatic pathway and/or at genetic level of K. oxytoca. Based on these data, it is speculated that biofiled treatment could be an alternative approach that can improve the effectiveness of the existing antimicrobials against the resistant pathogens

Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact of Biofield Treatment

International audienceObjective: Chloramphenicol and tetracycline are broad-spectrum antibiotics and widely used against variety of microbial infections. Nowadays, several microbes have acquired resistance to chloramphenicol and tetracycline. The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups.Results: FT-IR spectrum of treated chloramphenicol exhibited the decrease in wavenumber of NO2 from 1521 cm-1 to 1512 cm-1 and increase in wavenumber of C=O from 1681 cm-1 to 1694 cm-1 in acylamino group. It may be due to increase of conjugation effect in NO2 group, and increased force constant of C=O bond. As a result, stability of both NO2 and C=O groups might be increased in treated sample as compared to control. FT-IR spectrum of treated tetracycline showed the downstream shifting of aromatic C-H stretching from 3085-3024 cm-1 to 3064-3003 cm-1 and C=C stretching from 1648-1582 cm-1 to 1622-1569 cm-1 and up shifting of C-N stretching from 965 cm-1 to 995 cm-1. It may be due to enhanced conjugation effect in tetracycline, and increased force constant of C-N (CH3) bond of tetracycline as compared to control. The results indicated the enhanced stability of treated tetracycline as compared to control. UV-Vis spectra of biofield treated chloramphenicol and tetracycline showed the similar lambda max (λmax) to their respective control. It revealed that the chromophore groups of both antibiotics remained same as control after the biofield treatment.Conclusion: Based on FT-IR spectroscopic data, it is speculated that due to increase in bond strength and conjugation effect after biofield treatment, the chemical stability of both the drugs might be increased as compared to control

Effect of Biofield Treatment on Spectral Properties of Paracetamol and Piroxicam

International audienceParacetamol and piroxicam are non-steroidal anti-inflammatory drugs (NSAIDs), widely used in pain and inflammatory diseases. The present study aimed to evaluate the impact of biofield treatment on spectral properties of paracetamol and piroxicam. The study was performed in two groups (control and treatment) of each drug. The control groups remained as untreated, and biofield treatment was given to treatment groups. Subsequently, spectral properties of both drugs before and after biofield treatment were characterized using FT-IR and UV-Vis spectroscopic techniques. FT-IR data of paracetamol showed N-H amide II bending peak in biofield treated paracetamol, which was shifted to lower wavenumber (1565 to 1555 cm-1) as compared to control. Further, the intensity of vibrational peaks in the range of 1171-965 cm-1 (C-O and C-N stretching) were increased in treated sample of paracetamol as compared to control. Similarly, the FT-IR data of piroxicam (treated) showed increased intensity of vibrational peaks at 1628 (amide C=O stretching), 1576-1560 cm-1 (C=C stretching) with respect to control peaks. Furthermore, vibrational peak of C=N stretching (1467 cm-1) was observed in biofield treated piroxicam. This peak was not observed in control sample, possibly due to its low intensity. Based on FT-IR data, it is speculated that bond length and dipole moment of some bonds like N-H (amide), C-O, and C-N in paracetamol and C=O (amide), C=N, and C=C in piroxicam might be changed due to biofield treatment. The UV spectrum of biofield treated paracetamol showed the shifting in wavelength of UV absorption as 243→248.2 nm and 200→203.4 nm as compared to control. Likely, the lambda max (λmax) of treated piroxicam was also shifted as 328 →345.6 nm, 241→252.2 nm, and 205.2→203.2 nm as compared to control. Overall results showed an impact of biofield treatment on the spectral properties of paracetamol and piroxicam