Computer Govern Maintenance System for a Process Industry

The present paper deals with development of Computer Govern Maintenance System (CGMS) for a Process Industry. The developed software is easy to use, less complicated, less costly and less time consuming and consisting of number of modules like detailed information of equipment,  procedures of maintenance tasks, employees, work order, and calendar facility etc. The software has been developed in Microsoft Visual Studio.NET. The development of CGMS Software i.e. ‘IOCL CGMS’ at “IOCL Panipat   Refinery”, Panipat, may furnish good results. The currently developed CGMS aims to reduce total downtime, overall annual maintenance cost, frequency of failures of the machines, to get day-by-day maintenance schedule, maintenance policy. Keyword   : Computer Govern Maintenance System, Maintenance Schedule, Maintenance Policy

Comparative analysis of epinastine vs olopatadine eye drops in moderate allergic conjunctivitis patients

Background: Allergic conjunctivitis is a perennial ocular allergic disease. It is the inflammatory response of the conjunctiva to allergens such as pollen, animal dander, and other environmental allergens. The treatment consists of avoidance of the offending antigen, topical decongestants, antihistamines, mast cell stabilizers, non steroidal anti-inflammatory drugs and corticosteroids.Olopatadine hydrochloride 0.1% ophthalmic solution (Patanol) and Epinastine hydrochloride 0.05% ophthalmic solution (Elestat) are two topical ant allergic agents.Methods: After taking institutional ethics committee approval, total n= 62 (33, 29) patients were enrolled. Patients were randomized and divided into two study groups (1-olopatadine, 2-epinastine). After prescribing the drug therapy (day 1), patients were asked to visit at 3,7,15 day and at 1month. At every visit, slit lamp examination was done. Changes in all sign/symptoms were recorded. For the statistical testing of the data Chi-square test is used to find the association of variable. Mann Whitney -u test is applied for the statistically analysing the two group.Results: Both the study drugs found to be equally efficacious except at few points. Only statistically marked difference was observed in papillary hyperaemia (p<0.001) at 1 month where olopatadine found to be highly effective.Conclusions: Both drugs are found to be equally effective in moderate allergic conjunctivitis. Olopatadine is found effective in palpebral hyperaemia so it can be recommended in only moderate to severe conjunctivitis

ELEMENTAL ANALYSIS AND BIOLOGICAL STUDIES OF PHYSALIS ANGULATA L. USING WAVE LENGTH-DISPERSIVE X-RAY FLUORESCENCE TECHNIQUE, WAVELENGTH DISPERSION X-RAY FLUORESCENCE, FROM RAJASTHAN

Physalis angulata L. is an important medicinal plant, commonly known by different names such as mullaca, wintercherry, camapu, cutleaf, andreferred as pilu,†by local tribal people of Rajasthan. This plant species is distributed from temperate to tropical region of the world. Traditionally, ithas anticancerous, antimycobacterial, and anticoagulant properties. The juice is used in the treatment of earache, jaundice, fever, gonorrhea bladderdiseases, etc., cytological exploration of the species from Rajasthan revels the existence of two cytotypes diploid (2n=12) and tetraploid (2n=24). Thisstudy is undertaken to identify the total mineral content of both the cytotypes from different plant parts, i.e., fruit, leaf, stem, and roots by wavelength dispersion X-ray fluorescence technique which is a simple method, recognized as a nondestructive technique to determine the elements from the raw plant material without any chemical treatment and helps to ascertain the nutritional role. The analysis of mineral content led to the identification and concentration analysis of twenty-seven elements in diploid cytotype and twenty-five in tetraploid cytotype. The percentage value of potassium (5.52%); iron (0.50%) and selenium (0.0042%) is reported to be higher in diploid cytotype and the amount of calcium (2.15%); magnesium (0.75%) and zinc (0.0075%) are higher in tetraploid cytotype. The amount of most of the minerals is higher in tetraploid cytotype as compared to the diploid cytotype. This information is very helpful in standardization of herbal products as this plant species is widely used for its medicinal benefits

The extent of price variation amongst branded antihypertensive drugs and its association with number of pharmaceutical companies

Background: The study was performed to analyze the extent of price variation amongst branded antihypertensive drugs in India and the relation of this price variation to number of pharmaceutical companies manufacturing/marketing these drugs.Methods: Price of different brands of antihypertensive drugs was collected from authentic sources. The data were segregated and the percentage price variation was calculated applying suitable statistical tools.Results: A total of 116 formulations from different companies representing 38 antihypertensive drugs were analyzed. Maximum price variation (3233.33%) was seen with 10 mg dose of propranolol. In general the price variations are proportionally correlated to the number of pharmaceutical companies.Conclusions: Price variation of great extent was found among many formulations. Physicians should be aware of these variations for choosing the appropriate brand for rational therapeutics. This will reduce the burden on patients and family

Neutral Zone approach for severely atrophic ridges; Avenues beyond implants and surgeries – A Case Report

One of the most common problems encountered among long term denture wearers is the reduction in the denture foundation. Prosthodontic Rehabilitation of a patient with severely resorbed ridge is the most challenging therapy a prosthodontist can undertake. In order to have a favourable prognosis for the denture therapy, impression technique selected should be based on the present state of the basal tissue support. This article presents the application of neutral zone (NZ) concept being incorporated in to impression making procedure in an effort to achieve successful complete denture therapy

SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION

Objective: This work involves the synthesis of some novel schiff base derivatives synthesized from p-amino benzoic acid.Methods: A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, 1H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and anti-fungal activity against (Candida albicans and Aspergillus niger).Results: Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity.Conclusion: The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes

AN EVALUATION OF THE WOUND HEALING AND ANTI-MICROBIAL PROPERTY OF THE TINCTURE OF LANTANA CAMARA

Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2).Methods: An herbal tincture was developed from stems of L. cin concentrations of 20%, 40%, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa[a1] . Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies.Results: Both test groups were found statistically significant against standard with P&lt;0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P&lt;0.05 between the groups in incision model depicting 20% tincture as better with a mean value of 366.67±47.2. Histologically 40% tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions.Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.Â

Prevalence of tuberculosis in silicosis patients in southern part of Rajasthan

Background: Silicosis is an occupational lung disease which commonly occurs in workers involved in quarrying, mining, sandblasting etc. Tuberculosis (TB) in silicosis is more common. In southern part of Rajasthan, near Udaipur a lot of mining areas are there and workers are exposed to silica dust. The main objective of carrying out this study is to bring in focus the increasing prevalence of silicosis patients and its complications in mining areas around Udaipur in southern Rajasthan, so that the necessary prophylactic and preventive measures can be taken for the workers in future.Methods: 150 patients of silicosis and old treated case of silicotuberculosis patient with respiratory symptoms were included in the study. In all the patients, sputum was sent for routine acid fast bacilli (AFB) smear examination and if it came negative then sputum was sent for GeneXpert multidrug resistant tuberculosis (MTB) and also for AFB culture examination wherever needed.Results: The mean duration of exposure to silica particles was 10 years (5 to 15 years). Tuberculosis was diagnosed by microbiological examination in 40 cases, while 25 cases which were previously treated for tuberculosis were found negative on microbiological examination. So, the overall prevalence of TB (both old treated and new or relapse microbiologically confirmed cases) among patients of silicosis was found to be 44%.Conclusions: Our study showed an increased prevalence of tuberculosis in silicosis patients. So, there should be regular health check up educational programme for all silica mines workers and all should use prophylactic measures.

An experimental study on wistar rats to see the effect of Gymnema sylvestre on blood pressure

Background: Hypertension is a leading cause of morbidity and mortality globally. It is a well-known risk factor for an array of adverse cardiovascular outcomes. Obesity is considered as one of the major contributing factors to essential hypertension in humans. Obesity in itself is a risk factor for conditions like insulin resistance, hypertension, stroke, ischemic heart diseases, CHF etc. Undoubtedly in recent times we have achieved great advances in terms of management of hypertension but still we have miles to cover to have dominance over it. Gymnema sylvestre is a valuable indigenous herb. A number of animal and human studies have shown the potential role of Gymnema sylvestre (GS) as an anti-diabetic and anti-obesity agent.Methods: Adult Female Wistar rats, weighing between 150-200 gm, were included in the study. They were randomly divided into five groups with six rats in each group. High Fat Diet (HFD) was given for 4 weeks to induce hypertension in all the groups except group I which was fed with normal chow. Drugs along with respective diets were given to the rats for next 4 weeks by oral feeding cannula. Systolic blood pressure was measured by NIBP controller machine.Results: On feeding rats with HFD for 4 weeks the mean systolic blood pressure increased significantly. After giving drugs GS (100mg/kg), GS (200mg/kg) and Amlodipine (10mg/kg) to groups III, IV, V respectively for next 4 weeks, mean systolic blood pressure fell significantly (p <0.05) as compared to group II (HFD control group). At final evaluation at week 8 (as compared to Group 2) SBP got maximally reduced in Group 5 (35.1%) followed by Group 4 (26.4%), Group 3 (20.1%). On comparing Amlodipine standard (group 5) with other groups, a significant difference was found. This showed that Gymnema sylvestre reduced the elevated systolic blood pressure significantly but this anti-hypertensive effect was inferior to Amlodipine.Conclusions: The present study concludes that Gymnema sylvestre has a potent dose- dependent antihypertensive action but the effect is inferior to Amlodipine. Hence it can be used as an add-on to standard drugs for hypertension