An Analysis of DSR, DSDV, AODV and Adv.-AODV Routing Protocols in MANET

A mobile Ad-Hoc network is a collection of autonomous wireless nodes without any fixed infrastructure and centralized administration. Mobile ad hoc network (MANET) is an autonomous system of mobile nodes connected by wireless links. Each node operates not only as an end system, but also as a router to forward packets. The nodes are free to move about and organize themselves into a network. These nodes change position frequently. The main classes of routing protocols are Proactive, Reactive and Hybrid. A Reactive (on-demand) routing strategy is a popular routing category for wireless ad hoc routing The design follows the idea that each node tries to reduce routing overhead by sending routing packets whenever a communication is requested. In this paper, we evaluate the performance of reactive routing protocols, Ad hoc On demand Distance Vector (AODV) and Dynamic Source Routing (DSR) and proactive routing protocol Destination Sequenced Distance Vector (DSDV).The major goal of this study is to analyze the performance of well known MANETs routing protocol in high mobility case under low, medium and high density scenario. Unlike military applications, most of the other applications of MANETs require moderate to high mobility. In this paper, we evaluate the performance of reactive routing protocols, Advanced- Ad hoc On demand Distance Vector (Adv.-AODV), Ad hoc On demand Distance Vector (AODV) and Dynamic Source Routing (DSR) and proactive routing protocol Destination Sequenced Distance Vector (DSDV)[7][9].The major goal of this study is to analyze the performance of well known MANETs routing protocol in high mobility case under low, medium and high density scenario. Unlike military applications, most of the other applications of MANETs require moderate to high mobility. In this paper we analyzed the Adv.-AODV, AODV, DSDV and DSR protocols based on the performance metrics such as packet delivery ratio, average end to end delay and throughput in different test environments. DOI: 10.17762/ijritcc2321-8169.15081

Development of Nano SiO2 Particles Dispersed Shape Memory Epoxy Composites

Thermo responsive shape memory epoxy based composites are being investigated for their excellent mechanical and thermal properties. In present study the thermosetting epoxy containing different composition of SiO2 nano particles ranging from 1 to 4 wt. % have been prepared through solvent casting route. Developed composites have been studied for grain analysis, FTIR, shape recovery, impact strength and hardness. Addition of 3 wt. % SiO2 improves hardness and impact strength significantly. Average grain size of SiO2 particles increase at higher wt. % of SiO2 in polymer matrix due to agglomeration of nanoparticles

Mycobacterium tuberculosis NAD(+)-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I

DNA ligases are important enzymes which catalyze the joining of nicks between adjacent bases of double-stranded DNA. NAD(+)-dependent DNA ligases (LigA) are essential in bacteria and are absent in humans. They have therefore been identified as novel, validated and attractive drug targets. Using virtual screening against an in-house database of compounds and our recently determined crystal structure of the NAD(+) binding domain of the Mycobacterium tuberculosis LigA, we have identified N(1), N(n)-bis-(5-deoxy-α-d-xylofuranosylated) diamines as a novel class of inhibitors for this enzyme. Assays involving M.tuberculosis LigA, T4 ligase and human DNA ligase I show that these compounds specifically inhibit LigA from M.tuberculosis. In vitro kinetic and inhibition assays demonstrate that the compounds compete with NAD(+) for binding and inhibit enzyme activity with IC(50) values in the µM range. Docking studies rationalize the observed specificities and show that among several glycofuranosylated diamines, bis xylofuranosylated diamines with aminoalkyl and 1, 3-phenylene carbamoyl spacers mimic the binding modes of NAD(+) with the enzyme. Assays involving LigA-deficient bacterial strains show that in vivo inhibition of ligase by the compounds causes the observed antibacterial activities. They also demonstrate that the compounds exhibit in vivo specificity for LigA over ATP-dependent ligase. This class of inhibitors holds out the promise of rational development of new anti-tubercular agents

Enhancing productivity, economics and energy efficiency through precision nitrogen and water management in conservation agriculture-based maize (Zea mays) in the Indo-Gangetic Plains

Present study focuses on improving maize productivity, economics, and energy efficiency in the Indo-Gangetic Plains through the integration of CA, precision nitrogen and water management. Maize grain yield significantly differed among treatments, with CA outperforming CT by 13.3%, recording the highest yield with optimal N application (N3) and irrigation at 25% DASM. The CA incurred 23.7% lower cultivation costs (₹30,421/ha) compared to CT. Gross returns and net returns were higher under CA (₹1,16,007/ha and ₹85,586/ha) with a net benefit ratio of 2.78, showcasing its economic viability. Energy efficiency was a crucial aspect considered, with CA proving to be 33.1% more energy-efficient than CT. In different irrigation regimes, CA with W2 treatment exhibited superior energy parameters. The study also highlighted the significance of optimal N scheduling (N3) in achieving higher economic returns (₹97,927/ha) compared to conventional N splits (N1) and its integration. The most effective integration involved combining CA with precision N management (75% basal, GreenSeekerTM-guided top dressing) and irrigation at 25% DASM, resulting in higher grain yield (7.21 t/ ha), gross returns (₹132,497/ha), and impressive energy output (230,831 MJ/ha). In conclusion, CA, especially when combined with optimal irrigation and nitrogen management, not only enhances maize yield and economic returns but also proves to be more energy-efficient, promoting sustainable and resource-efficient agricultural practices. The study recommends this integrated approach for enhancing maize productivity, energy efficiency and economic returns

Optimization of FFF process parameters by naked mole-rat algorithms with enhanced exploration and exploitation capabilities

Fused filament fabrication (FFF) has numerous process parameters that influence the mechanical strength of parts. Hence, many optimization studies are performed using conventional tools and algorithms. Although studies have also been performed using advanced algorithms, limited research has been reported in which variants of the naked mole-rat algorithm (NMRA) are implemented for solving the optimization issues of manufacturing processes. This study was performed to scrutinize optimum parameters and their levels to attain maximum impact strength, flexural strength and tensile strength based on five different FFF process parameters. The algorithm yielded better results than other studies and successfully achieved a maximum response, which may be helpful to enhance the mechanical strength of FFF parts. The study opens a plethora of research prospects for implementing NMRA in manufacturing. Moreover, the findings may help identify critical parametric levels for the fabrication of customized products at the commercial level and help to attain the objectives of Industry 4.0

Common variants in CLDN2 and MORC4 genes confer disease susceptibility in patients with chronic pancreatitis

A recent Genome-wide Association Study (GWAS) identified association with variants in X-linked CLDN2 and MORC4 and PRSS1-PRSS2 loci with Chronic Pancreatitis (CP) in North American patients of European ancestry. We selected 9 variants from the reported GWAS and replicated the association with CP in Indian patients by genotyping 1807 unrelated Indians of Indo-European ethnicity, including 519 patients with CP and 1288 controls. The etiology of CP was idiopathic in 83.62% and alcoholic in 16.38% of 519 patients. Our study confirmed a significant association of 2 variants in CLDN2 gene (rs4409525—OR 1.71, P = 1.38 x 10-09; rs12008279—OR 1.56, P = 1.53 x 10-04) and 2 variants in MORC4 gene (rs12688220—OR 1.72, P = 9.20 x 10-09; rs6622126—OR 1.75, P = 4.04x10-05) in Indian patients with CP. We also found significant association at PRSS1-PRSS2 locus (OR 0.60; P = 9.92 x 10-06) and SAMD12-TNFRSF11B (OR 0.49, 95% CI [0.31–0.78], P = 0.0027). A variant in the gene MORC4 (rs12688220) showed significant interaction with alcohol (OR for homozygous and heterozygous risk allele -14.62 and 1.51 respectively, P = 0.0068) suggesting gene-environment interaction. A combined analysis of the genes CLDN2 and MORC4 based on an effective risk allele score revealed a higher percentage of individuals homozygous for the risk allele in CP cases with 5.09 fold enhanced risk in individuals with 7 or more effective risk alleles compared with individuals with 3 or less risk alleles (P = 1.88 x 10-14). Genetic variants in CLDN2 and MORC4 genes were associated with CP in Indian patients

Developing Standard Treatment Workflows—way to universal healthcare in India

Primary healthcare caters to nearly 70% of the population in India and provides treatment for approximately 80–90% of common conditions. To achieve universal health coverage (UHC), the Indian healthcare system is gearing up by initiating several schemes such as National Health Protection Scheme, Ayushman Bharat, Nutrition Supplementation Schemes, and Inderdhanush Schemes. The healthcare delivery system is facing challenges such as irrational use of medicines, over- and under-diagnosis, high out-of-pocket expenditure, lack of targeted attention to preventive and promotive health services, and poor referral mechanisms. Healthcare providers are unable to keep pace with the volume of growing new scientific evidence and rising healthcare costs as the literature is not published at the same pace. In addition, there is a lack of common standard treatment guidelines, workflows, and reference manuals from the Government of India. Indian Council of Medical Research in collaboration with the National Health Authority, Govt. of India, and the WHO India country office has developed Standard Treatment Workflows (STWs) with the objective to be utilized at various levels of healthcare starting from primary to tertiary level care. A systematic approach was adopted to formulate the STWs. An advisory committee was constituted for planning and oversight of the process. Specialty experts' group for each specialty comprised of clinicians working at government and private medical colleges and hospitals. The expert groups prioritized the topics through extensive literature searches and meeting with different stakeholders. Then, the contents of each STW were finalized in the form of single-pager infographics. These STWs were further reviewed by an editorial committee before publication. Presently, 125 STWs pertaining to 23 specialties have been developed. It needs to be ensured that STWs are implemented effectively at all levels and ensure quality healthcare at an affordable cost as part of UHC

Development of Nano SiO2 Particles Dispersed Shape Memory Epoxy Composites

21-24Thermo responsive shape memory epoxy based composites are being investigated for their excellent mechanical and thermal properties. In present study the thermosetting epoxy containing different composition of SiO2 nano particles ranging from 1 to 4 wt. % have been prepared through solvent casting route. Developed composites have been studied for grain analysis, FTIR, shape recovery, impact strength and hardness. Addition of 3 wt. % SiO2 improves hardness and impact strength significantly. Average grain size of SiO2 particles increase at higher wt. % of SiO2 in polymer matrix due to agglomeration of nanoparticles

Yield Performance and Nutrient Uptake of Indian Mustard (Brassica juncea L.) Varieties under Different Dates of Sowing and Planting Geometry

An investigation was conducted at research farm of SKUAST–Jammu. The experiment was laid out in factorial randomized block design with 18 treatments and three replications. The treatments consisted of three dates of sowing (25th October, 5th November and 15th November), two varieties (RL-1359 and NRCDR-2) and three spacing (30 cm x 10 cm, 30 cm x 20 cm and 30 cm x 30 cm). The results revealed that the highest seed yield 1710 kg ha-1 was recorded with 25th October sown crop and significant reduction to the extent of 15.02 and 31.63 per cent was recorded when sowing was delayed to 5th November and 15th November, respectively. Among the varieties, yield attributes of varieties such as number of silliquae per plant, and 1000-seed weight were significantly higher with NRCDR-2 than RL-1359. However, seeds siliqua-1 of both the varieties was at par. Variety NRCDR-2 also recorded significantly higher seed yield 1510 kg ha-1 which was about 9.57 per cent more in comparison to RL-1359 (1378 kg ha-1). However, seeds siliqua-1 and 1000-seed weight of 30 cm x 30 cm and 30 cm x 20 cm was at par but significantly superior to 30 cm x 10 cm whereas, silliquae plant-1 was significantly higher with spacing of 30 cm x 30 cm as compared to 30 cm x 10 cm and 30 cm x 20 cm. Nutrient uptake in Indian mustard varieties was also significantly higher in October 25 sown  crop along with the spacing of 30 cm x 10 cm at different dates of sowing and spacing. Among the varieties NRCDR-2 depicted significant higher nutrient uptake

Small-field Dosimetry of 6- and 10-MV Flattening Filter-free and Flattening Filter Photon Beams for Therapeutic Use

846-850This investigation aimed to measure and commission small unflat photon beams using the detectors described in our previous study10. Furthermore, the dosimetric parameters of small-field unflat and flat photon beams were compared to provide a better interpretation of beam energy and spectrum. The TrueBeam linear accelerator (TrueBeam LINAC, Varian Medical Systems) was employed in this study. The 10 and 6 MV unflat and flat photon beams were used to measure the output factor, depth dose, and beam profile of small-fields ranging in size from 1 cm × 1 cm to 6 cm × 6 cm. All measurements were performed according to the TRS-483 protocols established by the International Atomic Energy Agency. For both 10 and 6 MV, the output factors in unflat beam were significantly higher than in flat beam. The study found that unflat beam penumbras were slightly smaller than flat beam penumbras for both photon energies, which may improve tumor conformity and reduce doses to normal organs. The unflat photon beams had higher suface doses and lower depth doses at 10 cm than the flat photon beams for both energies, leading to considerably more beam energy degradation for unflat beams. The findings of this work are consistent with previously published data, and they will be useful for future research and LINAC commissioning