In-Vitro Mutagenic Studies in Solanum Viarum

Somaclonal variation for morphological traits was studied in both control and mutagen (chemicaland physical) treated progenies of two varieties of Solanum viarum. The SC1, SC1M1 (first generation followingtissue culture) and SC2, SC2M2 (second generation) of both 2n and 4n varieties on field evaluation showedbidirectional variation for plant height, plant spread, number of flowers and fruits per node and fresh fruitweight. Variation was more in number of fruits per node and fresh weight in physical mutagen treated progeniesin both the generations. The qualitative variations observed were less spine plants, dwarf plants, sterile planttypes and complete pollen sterility. The frequency of variations was different between varieties to varyingdegrees. SC2 and SC2M2 progenies on evaluation revealed increased variability compared to seed control for allthe traits indicating that these variabilities are not epigenetic in natur

A superior drug carrier – aponeocarzinostatin in partially unfolded state fully protects the labile antitumor enediyne

<p>Abstract</p> <p>Background</p> <p>Neocarzinostatin is a potent antitumor drug consisting of an enediyne chromophore and a protein carrier.</p> <p>Methods</p> <p>We characterized an intermediate in the equilibrium unfolding pathway of aponeocarzinostatin, using a variety of biophysical techniques including 1-anilino-8-napthalene sulfonate binding studies, size-exclusion fast protein liquid chromatography, intrinsic tryptophan fluorescence, circular dichroism, and ¹H-¹⁵N heteronuclear single quantum coherence spectroscopy.</p> <p>Results</p> <p>The partially unfolded protein is in molten globule-like state, in which ~60% and ~20% tertiary and secondary structure is disrupted respectively. Despite lacking a fully coordinated tertiary structure for assembling a functional binding cleft, the protein in molten globule-like state is still able to fully protect the labile chromophore. Titration of chromophore leads the partially denatured apoprotein to fold into its native state.</p> <p>Conclusion</p> <p>These findings bring insight into conserving mechanism of neocarzinostatin under harsh environment, where even the partially denatured apoprotein exhibits protective effect, confirming the superiority of the drug carrier.</p

Boundedness, compactness and Schatten-class membership of weighted composition operators

The boundedness and compactness of weighted composition operators on the Hardy space ${\mathcal H}^2$ of the unit disc is analysed. Particular reference is made to the case when the self-map of the disc is an inner function. Schatten-class membership is also considered; as a result, stronger forms of the two main results of a recent paper of Gunatillake are derived. Finally, weighted composition operators on weighted Bergman spaces $\mathcal{A}^2 \alpha(\mathbb{D})$ are considered, and the results of Harper and Smith, linking their properties to those of Carleson embeddings, are extended to this situation.Comment: 12 page

Inhomogeneous non-Gaussianity

We propose a method to probe higher-order correlators of the primordial density field through the inhomogeneity of local non-Gaussian parameters, such as f_NL, measured within smaller patches of the sky. Correlators between n-point functions measured in one patch of the sky and k-point functions measured in another patch depend upon the (n+k)-point functions over the entire sky. The inhomogeneity of non-Gaussian parameters may be a feasible way to detect or constrain higher-order correlators in local models of non-Gaussianity, as well as to distinguish between single and multiple-source scenarios for generating the primordial density perturbation, and more generally to probe the details of inflationary physics.Comment: 16 pages, 2 figures; v2: Minor changes and references added. Matches the published versio

Scale invariance in coarsening of binary and ternary fluids

Phase separation in binary and ternary fluids is studied using a two dimensional Lattice Gas Automata. The lengths, given by the the first zero crossing point of the correlation function and the total interface length is shown to exhibit power law dependence on time. In binary mixtures, our data clearly indicate the existence of a regime having more than one length scale where the coarsening process proceeds through the rupture and reassociation of domains. In ternary fluids; in the case of symmetric mixtures there exists a regime with a single length scale having dynamic exponent 1/2, while in asymmetric mixtures our data establish the break down of scale invariance.Comment: 20 pages, 13 figure

Mutated Hilltop Inflation : A Natural Choice for Early Universe

We propose a model of inflation with a suitable potential for a single scalar field which falls in the wide class of hilltop inflation. We derive the analytical expressions for most of the physical quantities related to inflation and show that all of them represent the true behavior as required from a model of inflation. We further subject the results to observational verification by formulating the theory of perturbations based on our model followed by an estimation for the values of those observable parameters. Our model is found to be in excellent agreement with observational data. Thus, the features related to the model leads us to infer that this type of hilltop inflation may be a natural choice for explaining the early universe.Comment: 22 pages, 7 figures, 2 tables. Matches published version in JCA

Non-Gaussianity from false vacuum inflation: Old curvaton scenario

We calculate the three-point correlation function of the comoving curvature perturbation generated during an inflationary epoch driven by false vacuum energy. We get a novel false vacuum shape bispectrum, which peaks in the equilateral limit. Using this result, we propose a scenario which we call "old curvaton". The shape of the resulting bispectrum lies between the local and the false vacuum shapes. In addition we have a large running of the spectral index.Comment: 13 pages, 3 figures; v2 with minor revison; v3 final version to appear on JCA

An Inflationary Scenario in Intersecting Brane Models

We propose a new scenario for D-term inflation which appears quite straightforwardly in the open string sector of intersecting brane models. We take the inflaton to be a chiral field in a bifundamental representation of the hidden sector and we argue that a sufficiently flat potential can be brane engineered. This type of model generically predicts a near gaussian red spectrum with negligible tensor modes. We note that this model can very naturally generate a baryon asymmetry at the end of inflation via the recently proposed hidden sector baryogenesis mechanism. We also discuss the possibility that Majorana masses for the neutrinos can be simultaneously generated by the tachyon condensation which ends inflation. Our proposed scenario is viable for both high and low scale supersymmetry breaking.Comment: 30 pages, 2 figures; v2 references and comments adde

Geometric effects on T-breaking in p+ip and d+id superconductors

Superconducting order parameters that change phase around the Fermi surface modify Josephson tunneling behavior, as in the phase-sensitive measurements that confirmed $d$ order in the cuprates. This paper studies Josephson coupling when the individual grains break time-reversal symmetry; the specific cases considered are $p \pm ip$ and $d \pm id$, which may appear in Sr$_2$RuO$_4$ and Na$_x$CoO$_2 \cdot$(H$_2$O)$_y$ respectively. $T$-breaking order parameters lead to frustrating phases when not all grains have the same sign of time-reversal symmetry breaking, and the effects of these frustrating phases depend sensitively on geometry for 2D arrays of coupled grains. These systems can show perfect superconducting order with or without macroscopic $T$-breaking. The honeycomb lattice of superconducting grains has a superconducting phase with no spontaneous breaking of $T$ but instead power-law correlations. The superconducting transition in this case is driven by binding of fractional vortices, and the zero-temperature criticality realizes a generalization of Baxter's three-color model.Comment: 8 page