Design and Optimization of Mefenamic acid Fast Dissolving Tablets Employing Modified Starch by 23 Factorial Design

Latest developments in the technology have promoted viable dosage alternatives through oral route for pediatrics, bed ridden, and nauseous patients. Patient preference is one of the most important aspects in pharmacy practice. Now a day’s pharmacy companies are coming up with innovative drug delivery systems to deliver the drugs efficiently and with less side effects. This innovation led to the introduction of the concept of fast dissolving tablets. Though, a wide range of superdisintegrant is available for formulation of fast dissolving tablets. Still there is continuous need of development of superdisintegrants. Therefore in the present investigation, starch based superdisintegrant was prepared and evaluated for its application in the design of fast dissolving dosage forms. Keywords: Fast Dissolving Tablets, Superdisintegrant, Modified Starch, Mefenamic acid

Multijet Discriminators for New Physics in Leptonic Signals at the LHC

Some of the cleanest signals for new physics in the early runs of the LHC will involve strongly-produced particles which give rise to multiple leptons by undergoing cascade decays through weakly-interacting states to stable particles. Some of the most spectacular final states will involve three or more leptons, multiple jets and generally missing energy-momentum as well. A triad of the most interesting models of new physics which induce such signals is known to consist of (i) supersymmetry with R-parity conservation, (ii) a universal extra dimension with conservation of KK-parity and (iii) little Higgs models with conserved T-parity. Similar signals could also arise if the Standard Model is augmented with a fourth sequential generation of heavy fermions. We study all these possibilities and show that a judiciously chosen set of observables, critically involving the number of identifiable jets and leptons, can collectively provide distinct footprints for each of these models. In fact, simple pairwise correlation of such observables can enable unambiguous identification of the underlying model, even with a relatively small data sample.Comment: 43 pages, LaTex2e, 8 embedded eps figure

Design, Optimization and Evaluation of Piroxicam Fast Dissolving Tablets Employing Modified Starch by 23 Factorial Design.

Fast dissolving tablet have potential advantages over conventional dosage forms, which has helped patient compliance, convenience, bioavailability and rapid onset of action. These are very good for drug delivery over geriatric and pediatric patients. They have significant advantages of solid and liquid dosage forms, because when they are in solid form and when transformed into liquid form and within few seconds after it is consumed. With new technologies for it formulation many commercial products are available in the market for the patients. So FDT have awful scope for being the delivery system. Therefore in the present investigation, starch based superdisintegrant was prepared and evaluated for its application in the design of fast dissolving dosage forms of piroxicam. Keywords: Fast Dissolving Tablets, Superdisintegrant, Modified Starch, Piroxicam

Cylindrical Shock in a Self-Gravitating Gas

The propagation of diverging cylindrical shock in a seif-gravitating gas having an initial density distribution p0, = betar-w, where beta and w are constants, has been studied for the two cases : (i) when the shock is strong and (ii) when it is weak. Analytical relations for shock velocity and shock strength have been obtained. It is shown that for strong shock, the shock velocity must decrease continuously with shock propagation; for weak shock, it initially decreases and attains a minimum value for certain propagation distance rumin and beyond this distance starts increasing.Finally, the expressions for the presure, the density and the particle velocity immediately behind the shock have been obtained for both the cases

Morbidity Pattern Among Out-Patients Attending Urban Health Training Centre in Srinagar

The current study was designed to identify the morbidity pattern of out-patients attending Urban Health Training Centre in an urban area of a medical college in Srinagar, Pauri Garhwal district, Uttarakhand, North India. The present study record-based retrospective study was conducted among the out-patients attending the regular clinic at the Urban Health Training Centre, of a medical college in Srinagar city of Uttarakhand State of North India during the study period of one year in 2014. Data was retrieved from the OPD registers maintained at the clinic. Data was collected pertaining to socio-demographic profile, morbidity details and treatment pattern. Diseases were identified using the International Classification of Diseases (ICD-10) code. Descriptive analysis was done. During the study period, a total of 9343 subjects attended the OPD. Among them, majority of them (60%) were females. More than half (56 %) belonged to the age group of 35-65 year age-group. The association of disease classification was found to be statistically significant with respect to gender. The leading morbidity of communicable disease was found to be certain infectious and parasitic diseases especially Typhoid whereas musculoskeletal system and connective tissue disorders were the most common cause among morbidity due to NCDs. Out of all, typhoid was found to cause maximum of morbidity among the subjects. The present study highlights the morbidity pattern of communicable and NCDs among the population of hilly areas of Garhwal, Uttarakhand India. Priority should be preferred for the regular tracking of diseases in terms of preventive and promotive aspects. Morbidity in the out- door clinics reflects the emerging trend of mixed disease spectrum burden comprising communicable and non-communicable diseases