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    A simple synthesis of 1,3-di-aryl-quinolone derivatives by palladium catalyzed cross-coupling reaction

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    698-705An efficient and novel method for the preparation of N-aryl-quinolone via enaminone synthesis has been described. Subsequent derivatization at 3 position has been accomplished by the palladium catalyzed Suzuki cross coupling reaction. Using this method, various aryl boronic acids as well as hetero aryl boronic acids have been coupled with 3-bromo-quinolone to generate the novel 1,3-di-aryl-quinolone derivatives. The key step quinolone ring formation has been achieved by intramolecular displacement reaction of enaminone 2 with suitably substituted ortho-fluoro group in the aromatic ring
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