Comparison of Beers criteria and EU(7) potentially inappropriate medications list for the potentially inappropriate medications in Indian elderly inpatients

Background: Use of inappropriate medication is an important problem in present geriatric clinical practice. No specific potentially inappropriate medications (PIM) tools are available considering the availability of drugs in India. Aim and objective were to assess prevalence and pattern of potentially inappropriate medication (PIM) use in elderly inpatients by updated Beers criteria 2015 and EU(7) PIM list 2015.Methods: This cross-sectional study was carried out on medical records of elderly patients (≥65 yrs) admitted in the internal medicine wards and intensive care units (ICU) over a period of 6 weeks. The medications were evaluated for the PIM use as per Beers criteria and EU(7) PIM list.Results: A total of 225 patients (mean age- 71.48 yrs) were admitted in internal medicine wards and ICU during study period. Total 184 PIM belonged to 33 different medications were used during study period. The prevalence of PIM in internal medicine wards and ICUs were 51.96% and 57.14%, respectively. The prevalence of PIM was significantly higher with the EU(7) PIM list than Beers criteria (49.77% vs. 21.77%) [p<0.0001]. The commonly prescribed PIM were dextromethorphan (13.33%), ranitidine (11.11%) and glipizide (10.22%).Conclusions: Elderly patients frequently receive PIM. EU(7) PIM list identifies more PIM among elderly inpatients than Beers criteria

UB CANSAT Competition 2017

Our mission objective is to create a solar powered science glider that can sample the atmospheric conditions like pressure, temperature, altitude and positioning during flight and compete in the CanSat competition. To model and design a solar powered glider and re-entry container. The glider is designed in such a way as to hold all the sensors for sampling and solar panels to power up the glider. To make the glider move in a circular pattern during descent with a diameter not more than 1000m

Use of Plasma Pseudocholinesterase as a Predictor of Mortality in Organophosphate Poisoning

The study was conducted on patients of organophosphate poisoning admitted to Bapuji Hospital (J. J. M. Medical College), Davangere during a period of October 2011 to March 2013. To know the incidence of acute Organophosphate poisoning, epidemiological aspects of the patient and plasma pseudocholinesterase levels at the time of admission and correlation within hospital mortality. Total number of cases studied were 150. At the time of admission blood was drawn for estimation of plasma pseudocholinesterase estimation. The patients were clinically divided into three grades according to Dreishbachs criteria. Analysis was performed by cobas integra 400 cholinesterase assay system. All patients were followed-up for 3 days to know the outcome. Majority of the cases (40%) belong to 21 to 30 years age group and predominantly belonged to male sex (73%). Seventy eight cases (52%) had severe poisoning, 40 cases (26.67%) had moderate poisoning and 32 cases (21.33%) had mild poisoning. Sixty cases (40%) had fatal outcome. Suicidal consumption was seen in 128 cases (85.33%). Plasma pseudocholinesterase levels associated with fatalities in severe poisoning and was found to range from 912 to 2490 U/L which accounts to suppression of plasma pseudocholinesterase levels by 84.04 to 93.19%

CD56 regulates human NK cell cytotoxicity through Pyk2

Human natural killer (NK) cells are defined as CD5

CD56 regulates human NK cell cytotoxicity through Pyk2

Human natural killer (NK) cells are defined as CD56+CD3. Despite its ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell cytotoxic function has not been defined. In non-immune cells, NCAM can induce signaling, mediate adhesion, and promote exocytosis through interactions with focal adhesion kinase (FAK). Here we demonstrate that deletion of CD56 on the NK92 cell line leads to impaired cytotoxic function. CD56-knockout (KO) cells fail to polarize during immunological synapse (IS) formation and have severely impaired exocytosis of lytic granules. Phosphorylation of the FAK family member Pyk2 at tyrosine 402 is decreased in NK92 CD56-KO cells, demonstrating a functional link between CD56 and signaling in human NK cells. Cytotoxicity, lytic granule exocytosis, and the phosphorylation of Pyk2 are rescued by the reintroduction of CD56. These data highlight a novel functional role for CD56 in stimulating exocytosis and promoting cytotoxicity in human NK cells