Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis

No abstract available

Precise Determination of the Neutron Magnetic Form Factor to Higher Q2Q^2

The neutron elastic magnetic form factor $G_M^n$ has been extracted from quasielastic scattering from deuterium in the CEBAF Large Acceptance Spectrometer, CLAS. The kinematic coverage of the measurement is continuous over a broad range, extending from below 1 $GeV^2$ to nearly 5 $GeV^2$ in four-momentum transfer squared. High precision is achieved by employing a ratio technique in which most uncertainties cancel, and by a simultaneous in-situ calibration of the neutron detection efficiency, the largest correction to the data. Preliminary results are shown with statistical errors only.Comment: Contribution to the proceedings of the Tenth International Conference on Baryons (2004), to be published in Nuclear Physics, Section

Free-living nitrogen fixation in Saskatchewan agriculture

Non-Peer Reviewe

Burkhardt-Cottingham sum rule and forward spin polarizabilities in Heavy Baryon Chiral Perturbation Theory

We study spin-dependent sum rules for forward virtual Compton scattering(VVCS) off the nucleon in heavy baryon chiral perturbation theory at order $O(p^4)$. We show how these sum rules can be evaluated from low energy expansions (in the virtual photon energy) of the forward VVCS amplitudes. We study in particular the Burkhardt -Cottingham sum rule in HBChPT and higher terms in the low energy expansion, which can be related to the generalized forward spin polarizabilities of the nucleon. The dependence of these observables on the photon virtuality $Q^2$ can be accessed, at small and intermediate $Q^2$ values, from existing and forthcoming data at Jefferson Lab.Comment: 16 pages,4 fig

Spacetime Virasoro algebra from strings on zero radius AdS_3

We study bosonic string theory in the light-cone gauge on AdS_3 spacetime with zero radius of curvature (in string units) R/\sqrt{\alpha^\prime}=0. We find that the worldsheet theory admits an infinite number of conserved quantities which are naturally interpreted as spacetime charges and which form a representation of (two commuting copies of) a Virasoro algebra. Near the boundary of AdS_3 these charges are found to be isomorphic to the infinite set of asymptotic Killing vectors of AdS_3 found originally by Brown and Henneaux. In addition to the spacetime Virasoro algebra, there is a worldsheet Virasoro algebra that generates diffeomorphisms of the spatial coordinate of the string worldsheet. We find that if the worldsheet Virasoro algebra has a central extension then the spacetime Virasoro algebra acquires a central extension via a mechanism similar to that encountered in the context of the SL(2,R) WZW model.Our observations are consistent with a recently proposed duality between bosonic strings on zero radius AdS_d+1 and free field theory in d dimensions.Comment: 23 pages, uses JHEP.cls. References adde

Parametrically Excited Surface Waves: Two-Frequency Forcing, Normal Form Symmetries, and Pattern Selection

Motivated by experimental observations of exotic standing wave patterns in the two-frequency Faraday experiment, we investigate the role of normal form symmetries in the pattern selection problem. With forcing frequency components in ratio m/n, where m and n are co-prime integers, there is the possibility that both harmonic and subharmonic waves may lose stability simultaneously, each with a different wavenumber. We focus on this situation and compare the case where the harmonic waves have a longer wavelength than the subharmonic waves with the case where the harmonic waves have a shorter wavelength. We show that in the former case a normal form transformation can be used to remove all quadratic terms from the amplitude equations governing the relevant resonant triad interactions. Thus the role of resonant triads in the pattern selection problem is greatly diminished in this situation. We verify our general results within the example of one-dimensional surface wave solutions of the Zhang-Vinals model of the two-frequency Faraday problem. In one-dimension, a 1:2 spatial resonance takes the place of a resonant triad in our investigation. We find that when the bifurcating modes are in this spatial resonance, it dramatically effects the bifurcation to subharmonic waves in the case of forcing frequencies are in ratio 1/2; this is consistent with the results of Zhang and Vinals. In sharp contrast, we find that when the forcing frequencies are in ratio 2/3, the bifurcation to (sub)harmonic waves is insensitive to the presence of another spatially-resonant bifurcating mode.Comment: 22 pages, 6 figures, late

Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH₂) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury.

The mitochondria-active tetrapeptide SS-31 can control oxidative tissue damage in kidney diseases. To investigate other potential beneficial nephroprotective effects of SS-31, in vivo murine models of acute tubular injury and glomerular damage were developed. Reduction of acute kidney injury was demonstrated in mice treated with SS-31. The expression of mRNAs involved in acute inflammatory and oxidative stress responses in the diseased kidneys confirmed that SS-31 could regulate these pathways in our in vivo models. Furthermore, ex vivo histoenzymography of mouse kidneys showed that aminopeptidase A (APA), the enzyme involved in the processing of angiotensin (Ang) II to Ang III, was induced in the diseased kidneys, and its activity was inhibited by SS-31. As the renin-angiotensin system (RAS) is a main regulator of kidney functions, the modulation of Ang receptors (ATR) and APA by SS-31 was further investigated using mRNAs extracted from diseased kidneys. Following acute tubular and/or glomerular damage, the expression of the AT <sub>1</sub> R mRNA was upregulated, which could be selectively downregulated upon SS-31 administration to the animals. At the same time, SS-31 was able to increase the expression of the AT <sub>2</sub> R, which may contribute to limit renal damage. Consequently, SS-31-based prodrugs were developed as substrates and/or inhibitors for APA and were screened using cells expressing high levels of APA, showing its selective regulation by α-Glu-SS-31. Thus, a link between SS-31 and the RAS opens new therapeutic implications for SS-31 in kidney diseases

A New Class of Inhomogeneous String Cosmological Models in General Relativity

A new class of solutions of Einstein field equations has been investigated for inhomogeneous cylindrically symmetric space-time with string source. To get the deterministic solution, it has been assumed that the expansion ($\theta$) in the model is proportional to the eigen value $\sigma^{1}_{1}$ of the shear tensor $\sigma^{i}_{j}$. Certain physical and geometric properties of the models are also discussed.Comment: 12 pages, no figure. Submitted to Astrophys. Space Sci. arXiv admin note: substantial text overlap with arXiv:0705.090

Bianchi type II models in the presence of perfect fluid and anisotropic dark energy

Spatially homogeneous but totally anisotropic and non-flat Bianchi type II cosmological model has been studied in general relativity in the presence of two minimally interacting fluids; a perfect fluid as the matter fluid and a hypothetical anisotropic fluid as the dark energy fluid. The Einstein's field equations have been solved by applying two kinematical ans\"{a}tze: we have assumed the variation law for the mean Hubble parameter that yields a constant value of deceleration parameter, and one of the components of the shear tensor has been considered proportional to the mean Hubble parameter. We have particularly dwelled on the accelerating models with non-divergent expansion anisotropy as the Universe evolves. Yielding anisotropic pressure, the fluid we consider in the context of dark energy, can produce results that can be produced in the presence of isotropic fluid in accordance with the \Lambda CDM cosmology. However, the derived model gives additional opportunities by being able to allow kinematics that cannot be produced in the presence of fluids that yield only isotropic pressure. We have obtained well behaving cases where the anisotropy of the expansion and the anisotropy of the fluid converge to finite values (include zero) in the late Universe. We have also showed that although the metric we consider is totally anisotropic, the anisotropy of the dark energy is constrained to be axially symmetric, as long as the overall energy momentum tensor possesses zero shear stress.Comment: 15 pages; 5 figures; matches the version published in The European Physical Journal Plu

Partial Dynamical SU(3) Symmetry and the Nature of the Lowest K=0 Collective Excitation in Deformed Nuclei

We discuss the implications of partial dynamical SU(3) symmetry (PDS) for the structure of the lowest K=0^{+} (K=0_2) collective excitation in deformed nuclei. We consider an interacting boson model Hamiltonian whose ground and gamma bands have good SU(3) symmetry while the K=0_2 band is mixed. It is shown that the double-phonon components in the K=0_2 wave function arise from SU(3) admixtures which, in turn, can be determined from absolute E2 rates connecting the K=0_2 and ground bands. An explicit expression is derived for these admixtures in terms of the ratio of K=0_2 and gamma bandhead energies. The SU(3) PDS predictions are compared with existing data and with broken-SU(3) calculations for ^{168}Er.Comment: 12 pages, 2 figure