A non-obese, diet-induced animal model of nonalcoholic steatohepatitis in Wistar/ST rats compared to Sprague-Dawley rats

Background: Non-alcoholic steatohepatitis (NASH), a subtype of non-alcoholic fatty liver disease (NAFLD), is a potentially progressive liver disease that can lead to cirrhosis. Obesity increases the risk of NAFLD/NASH, but this disease can also be observed in non-obese individuals. Methods: We investigated the metabolic and histopathological changes in 13 obesity-resistant Slc:Wistar/ST rats fed a high-fat and high-cholesterol (HFC) diet for 9 weeks, and also retrospectively compared the results of 41 Sprague-Dawley (SD) rats that were previously fed with the same protocol to the results of the Slc:Wistar/ST rats. Results: Of the 13 Slc:Wistar/ST rats fed an HFC diet containing 1.25% or 2.5% cholesterol, 11 (84.6%) developed histologically proven NASH without obesity, an increased visceral fat volume, insulin resistance, histopatological severe lobular inflammation and severe hepatic fibrosis. The HFC diets significantly increased the levels of mRNA encoding collagen type I alpha 1 (COL1A1), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1). The SD rats also developed NASH without obesity, an increased visceral fat volume and insulin resistance, but the metabolic and histopathological effects, such as lower serum adiponectin levels, higher serum leptin levels, histopatological severe lobular inflammation and hepatic fibrosis, seemed to be more pronounced in the SD rats than in the Slc:Wistar/ST rats. Conclusions: These two rat models may reflect the human etiology of NASH that is influenced by dietary factors, and the obesity-resistant Slc:Wistar/ST rat model may be particularly useful for elucidating the pathophysiological mechanism of the so-called “lean NASH”

Fighting the Backlash against Racial Justice: The Black Struggle for Anti-Racism Education and Black Studies

論文Articlesdepartmental bulletin pape

人種的正義をめざす教育と研究への反動、反人種主義教育とブラック・スタディーズを守り抜くための抵抗

論文Article

ダリット女性および部落女性における複合差別とエンパワーメントに関する国際比較研究

部落女性が担ってきた社会運動の歴史的社会的意義、彼女たちの実践と思想に通底する交差性／複合差別アプローチ、行為主体である部落女性の社会的位置、これらに関する研究成果を発表し、日本の差別論が独特の知的達成を経てきたことを示した。ダリット女性および部落女性が被る抑圧を決定づけているいくつもの条件のからみあい、それらを位置づける社会的権力関係を解明するにあたり、彼女たちによる交差性／複合差別アプローチに基づく理論と実践の思想的展開を確認し、性、人種、世系、階級といった要因の共通性と相違性を明らかにした。The theory of discrimination in Japan has undergone a unique intellectual evolution. The research presents findings on the historical and social significance of Buraku women's social movements. It also emphasizes the intersectionality approach that underpins their practices and ideologies as well as their socioeconomic position in Japanese society. Furthermore, my research highlights the development of theory and practice based on an intersectionality approach by Dalit and Buraku women. In examining the interplay between conditions that determine oppression and the social power relations that embody them, I explain the similarities and differences among various factors, including gender, race, descent, and class.研究分野：社会運動思想

Dalit and Buraku Women's Intersectionality and Empowerment: An International Comparative Study

部落女性が担ってきた社会運動の歴史的社会的意義、彼女たちの実践と思想に通底する交差性／複合差別アプローチ、行為主体である部落女性の社会的位置、これらに関する研究成果を発表し、日本の差別論が独特の知的達成を経てきたことを示した。ダリット女性および部落女性が被る抑圧を決定づけているいくつもの条件のからみあい、それらを位置づける社会的権力関係を解明するにあたり、彼女たちによる交差性／複合差別アプローチに基づく理論と実践の思想的展開を確認し、性、人種、世系、階級といった要因の共通性と相違性を明らかにした。The theory of discrimination in Japan has undergone a unique intellectual evolution. The research presents findings on the historical and social significance of Buraku women's social movements. It also emphasizes the intersectionality approach that underpins their practices and ideologies as well as their socioeconomic position in Japanese society. Furthermore, my research highlights the development of theory and practice based on an intersectionality approach by Dalit and Buraku women. In examining the interplay between conditions that determine oppression and the social power relations that embody them, I explain the similarities and differences among various factors, including gender, race, descent, and class.研究分野：社会運動思想