6 research outputs found
アヒルテンブスウイルスおよび日本脳炎ウイルス感染に対するアヒル細胞の応答ならびにアヒルテンブスウイルス感染神経細胞に対するミノサイクリンの効果に関する研究 [論文内容及び審査の要旨]
No full text
Studies on the cellular responses of duck cells to Duck Tembusu virus and Japanese encephalitis virus infection and the effect of minocycline on Duck Tembusu virus-infected neurons
No full textStudies on the cellular responses of duck cells to Duck Tembusu virus and Japanese encephalitis virus infection and the effect of minocycline on Duck Tembusu virus-infected neurons [an abstract of dissertation and a summary of dissertation review]
No full textMinocycline prevents primary duck neurons from duck Tembusu virus-induced death
No full textDuck Tembusu virus (DTMUV), a neurotropic flavivirus, is a causative agent of severe neurological diseases in different birds. No approved vaccines or antiviral therapeutic treatments are available to date. The poultry industry experiences significant economic losses due to DTMUV infections. Minocycline is a second- generation semi-synthetic tetracycline analogue that is commonly used as an antimicrobial treatment. Experimental studies have indicated the successful protective effects of minocycline against neuronal cell death from neurodegenerative diseases and viral encephalitis. The aim of this study was to investigate the effects of minocycline on DTMUV infection in neurons. Primary duck neurons were treated with minocycline, which exhibited neuroprotective effects via anti-apoptotic function rather than through viral replication inhibition. Minocycline might serve as a potential effective drug in DTMUV infection
