70 research outputs found
Clinical efficacy of a betablockers therapy in patients with chronic heart failure on the background of postinfarction cardiosclerosis
Despite the fact that betablockers (BBs) are one of the main groups of therapy of patients with acute myocardial infarction (AMI), the comparative effectiveness of various BBs in patients with postinfarction cardiosclerosis (PICS) is uncertain. There was performed comparative analysis of clinical efficacy of BBs in patients with chronic heart failure (CHF) on the background of coronary heart disease (CHD), PICS. There was evaluated the impact of metoprolol succinate, carvedilol, bisoprolol and betaxolol on blood pressure (BP), left ventricular ejection fraction (LVEF), change the functional class of chronic heart failure, and mortality in patients over 4 year
Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease
Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor
Study of sedative tea phytocomplex within the framework of studies aimed at creation of a rectal dosage form with antihistaminic effect
We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compound
Genetic determinants of endometriosis and uterine myoma combinatin
The objective of the research was a bioinformatic study of the involvement of candidate genes in the formation of a combination of endometriosis with uterine myoma in wome
Candidate genes and clinical-laboratory indices in pregnant women depending on the development of preeclampsia
The relationship between polymorphic variants of folate metabolism genes with clinical (blood pressure level before and at the end of pregnancy) and clinical and laboratory indicators (proteinuria, fibrinogen, total protein, urea and creatinine in the blood, activated partial thromboplastin time, thrombin time) were studied in pregnant women with preeclampsi
Open Clusters IC 4665 and Cr 359 and a Probable Birthplace of the Pulsar PSR B1929+10
Based on the epicyclic approximation, we have simulated the motion of the
young open star clusters IC 4665 and Collinder 359. The separation between the
cluster centers is shown to have been minimal 7 Myr ago, 36 pc. We have
established a close evolutionary connection between IC 4665 and the
Scorpius-Centaurus association -- the separation between the centers of these
structures was pc 15 Myr ago. In addition, the center of IC 4665
at this time was near two well-known regions of coronal gas: the Local Bubble
and the North Polar Spur. The star HIP 86768 is shown to be one of the
candidates for a binary (in the past) with the pulsar PSR B1929+10. At the
model radial velocity of the pulsar km s, a close
encounter of this pair occurs in the vicinity of IC 4665 at a time of -1.1 Myr.
At the same time, using currently available data for the pulsar B1929+10 at its
model radial velocity km s, we show that the hypothesis
of Hoogerwerf et al. (2001) about the breakup of the Oph--B1929+10
binary in the vicinity of Upper Scorpius (US) about 0.9 Myr ago is more
plausible.Comment: 19 pages, 8 figure
Kinematic Control of the Inertiality of ICRS Catalogs
We perform a kinematic analysis of the Hipparcos and TRC proper motions of
stars by using a linear Ogorodnikov-Milne model. All of the distant (r more
than 0.2 kpc) stars of the Hipparcos catalog have been found to rotate around
the Galactic y axis with an angular velocity of -0.36 +/- 0.09 mas/year. One of
the causes of this rotation may be an uncertainty in the lunisolar precession
constant adopted when constructing the ICRS. In this case? the correction to
the IAU (1976) lunisolar precession constant in longitude is shown to be -3.26
+/- 0.10 mas/yr. Based on the TRC catalog, we have determined the main Oort
constants: A = 14.9 +/- 1.0 and B = -10.8 +/- 0.3 km/s/kpc. The component of
the model that describes the rotation of all TRC stars around the Galactic y
axis is nonzero for all magnitudes, My= -0.86 +/- 0.11 mas/yr.Comment: 10 pages, 4 figures, 2 table
Dynamics of Gaseous Disks in a Non-axisymmetric Dark Halo
The dynamics of a galactic disk in a non-axisymmetric (triaxial) dark halo is
studied in detail using high-resolution, numerical, hydrodynamical models. A
long-lived, two-armed spiral pattern is generated for a wide range of
parameters. The spiral structure is global, and the number of turns can be two
or three, depending on the model parameters. The morphology and kinematics of
the spiral pattern are studied as functions of the halo and disk parameters.
The spiral structure rotates slowly, and its angular velocity varies
quasi-periodically. Models with differing relative halo masses, halo semi-axis
ratios, distributions of matter in the disk, Mach numbers in the gaseous
component, and angular rotational velocities of their halos are considered.Comment: 22 pages, 11 figure
Kinematic Peculiarities of Gould Belt Stars
We analyzed the space velocities of Gould Belt stars younger than 125 Myr
located at heliocentric distances <650 pc. We determined the rotation and
expansion parameters of the Gould Belt by assuming the existence of a single
kinematic center whose direction was found to be the following:
and pc. The linear velocities reach their
maximum at a distance of pc from the center and are -6 km s
for the rotation (whose direction coincides with the Galactic rotation) and +4
km s for the expansion. The stellar rotation model used here is shown to
give a more faithful description of the observed velocity field than the linear
model based on the Oort constants and . We present evidence that the
young clusters Pic, Tuc/HorA, and TWA belong to the Gould Belt
structure.Comment: 17 pages, 5 figure
Genetic determinants of endometriosis and uterine myoma combinatin
The objective of the research was a bioinformatic study of the involvement of candidate genes in the formation of a combination of endometriosis with uterine myoma in wome
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