Assessing the Effective Energy for Magnetic Forming Processes by Means of Measurements and Numerical Calculation

The efficiency of magnetic sheet metal forming processes is strongly depending on the facility s overall design. This mainly includes the geometric layout of forming tool, work piece and matrix but, however, will also expect the energy storage device being taken into consideration. Apart from field theoretic models the energy storage is describable by its terminal traits which the electric load - tool coil and work piece - is connected to. The paper presents a measuring method for the tool coil s terminal quantities, current i(t) and voltage u(t), which are used to provide the electric power p(t) being transferred to the load. Thus, it is possible to determine the entire energy which is dissipated by the work piece, provided that the coil s resistance is known. Besides the measurement, this approach is supported by numerical calculation intending to take a closer look at the inner losses of the work piece which are not accessible from measuring the system s terminal traits directly. Dividable into separate parts of the total energy, this information is applied to assess the forming process by means of the facility s energetic performance and to draw an overall energy balance

Identification of potential neuromotor mechanisms of manual therapy in patients with musculoskeletal disablement: rationale and description of a clinical trial

<p>Abstract</p> <p>Background</p> <p>Many health care practitioners use a variety of hands-on treatments to improve symptoms and disablement in patients with musculoskeletal pathology.</p> <p>Research to date indirectly suggests a potentially broad effect of manual therapy on the neuromotor processing of functional behavior within the supraspinal central nervous system (CNS) in a manner that may be independent of modification at the level of local spinal circuits. However, the effect of treatment speed, as well as the specific mechanism and locus of CNS changes, remain unclear.</p> <p>Methods/Design</p> <p>We developed a placebo-controlled, randomized study to test the hypothesis that manual therapy procedures directed to the talocrural joint in individuals with post-acute ankle sprain induce a change in corticospinal excitability that is relevant to improve the performance of lower extremity functional behavior.</p> <p>Discussion</p> <p>This study is designed to identify potential neuromotor changes associated with manual therapy procedures directed to the appendicular skeleton, compare the relative effect of treatment speed on potential neuromotor effects of manual therapy procedures, and determine the behavioral relevance of potential neuromotor effects of manual therapy procedures.</p> <p>Trial Registration</p> <p><url>http://www.clinicaltrials.gov</url> identifier NCT00847769.</p

The concepts of resiliency: Theoretical lessons from community research

Resiliency is a concept for which both its appeal and frustration comes from the elasticity of its meaning. The idea of resiliency commonly has been found in areas of human development and psychopathology, there is now an increased interest in extending its application. Community resiliency is increasingly a central element in public health policies and programs. In what follows, we strive to identify some central theoretical issues that arise when the concept of resiliency is applied to communities. Our purpose is to work through these issues in a way that clarifies the concept by bringing together useful, though otherwise disparate, strands from the research literature.Special thank you to Barry Edginton for allowing us to post this article.Ye

Exciton propagation and halo formation in two-dimensional materials

The interplay of optics, dynamics and transport is crucial for the design of novel optoelectronic devices, such as photodetectors and solar cells. In this context, transition metal dichalcogenides (TMDs) have received much attention. Here, strongly bound excitons dominate optical excitation, carrier dynamics and diffusion processes. While the first two have been intensively studied, there is a lack of fundamental understanding of non-equilibrium phenomena associated with exciton transport that is of central importance e.g. for high efficiency light harvesting. In this work, we provide microscopic insights into the interplay of exciton propagation and many-particle interactions in TMDs. Based on a fully quantum mechanical approach and in excellent agreement with photoluminescence measurements, we show that Auger recombination and emission of hot phonons act as a heating mechanism giving rise to strong spatial gradients in excitonic temperature. The resulting thermal drift leads to an unconventional exciton diffusion characterized by spatial exciton halos

Exciton diffusion in monolayer semiconductors with suppressed disorder

Tightly bound excitons in monolayer semiconductors represent a versatile platform to study two-dimensional propagation of neutral quasiparticles. Their intrinsic properties, however, can be severely obscured by spatial energy fluctuations due to a high sensitivity to the immediate environment. Here, we take advantage of the encapsulation of individual layers in hexagonal boron nitride to strongly suppress environmental disorder. Diffusion of excitons is then directly monitored using time and spatially resolved emission microscopy at ambient conditions. We consistently find very efficient propagation with linear diffusion coefficients up to 10 cm(2)/s, corresponding to room-temperature effective mobilities as high as 400 cm(2)/Vs as well as a correlation between rapid diffusion and short population lifetime. At elevated densities we detect distinct signatures of many-particle interactions and consequences of strongly suppressed Auger-type exciton-exciton annihilation. A combination of analytical and numerical theoretical approaches is employed to provide pathways toward comprehensive understanding of the observed linear and nonlinear propagation phenomena. We emphasize the role of dark exciton states and present a mechanism for diffusion facilitated by free-electron hole plasma from entropy-ionized excitons

Toxicity of mercury to hybridoma TA7 cells

Environmental mercury and mercury compound contamination has increased dramatically since the industrial revolution. This paper describes the toxic effects of mercury on a culture of hybridoma TA7 cells, which produce antibodies against the A-subunit of viskumin. Cells were cultivated on 96- well flat-bottomed plates with RPMI-1640 medium supplemented with 10% fetal calf serum at 37°C in 5% CO2/95% air. The cells were exposed to 0.1nM/l- 10μM/l Hg2(NO3)2·2H2O (mercury nitrate) during the exponential growth phase. Toxicity was assessed by using the colorimetric MTT (tetrazolium) assay after exposure for 48 hours. Cell growth and cell survival were evaluated by using percentage indices of cellular content in exposed cells when compared to non-exposed control cells. The concentrations of the no- effect level, the lowest observed effect level and the the highest toxic effect level were registered. The toxic effects of the mercury compound on the hybridoma cells occurred between 0.1μM/l and 10μM/l.Peer reviewe

QSAR studies on a number of pyrrolidin-2-one antiarrhythmic arylpiperazinyls

The activity of a number of 1-[3-(4-arylpiperazin-1-yl)propyl]pyrrolidin-2-one antiarrhythmic (AA) agents was described using the quantitative structure–activity relationship model by applying it to 33 compounds. The molecular descriptors of the AA activity were obtained by quantum chemical calculations combined with molecular modeling calculations. The resulting model explains up to 91% of the variance and it was successfully validated by four tests (LOO, LMO, external test, and Y-scrambling test). Statistical analysis shows that the AA activity of the studied compounds depends mainly on the PCR and JGI4 descriptors