BIOMIMETIC STRATEGIES IN ORGANIC SYNTHESIS. TERPENES

The current paper represents an outline of the selected contributions to the biomimetic procedures and approaches for the synthesis of terpenes with complex structure and diverse functionalisation pattern. These include homologation strategies, cyclisations, rearrangements, as well as biomimetic remote functionalisations

CONTINUOUS EVOLUTION IN COLABORATIONS BETWEEN MOLDOVAN AND ITALIAN CHEMISTS

Moldovan chemists hosted the Italian partners in Chisinau and organized in premiere for the last 20 years an international seminar devoted to the chemistry of natural products. The seminar’s motto: New Frontiers in the Chemistry of Natural Products has addressed numerous students and researchers acting in the fields of chemistry, biology, pharmacy, genetics, biophysics as well as specialists from the R&D sector of companies with chemico-pharmaceutical profile. Following multiple solicitations coming from seminar audience, made us provide in the current issue of the “Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry” a condensed abstract of the seminar presentations. We do really hope that our joint event will give further impetus to our collaboration and will also motivate other researchers from Moldova to develop partnerships with European colleagues

Biodiversitatea compoziției chimice a uleiului esențial la speciile genului Hypericum L. din flora spontană a Republicii Moldova

Speciile genului Hypericum L. din flora spontană a Republicii Moldova se deosebesc prin conținutul și componența uleiului esențial obținut prin hidrodistilare în aparate Ginsberg din partea aeriană a plantei (Hyperici herba). H. perforatum conține în herba 0,26% (s.u.) ulei esențial, H. elegans - 0,15% (s.u.), H. hirsutum - 0,094% (s.u.) și H. tetrapterum - 0,13% (s.u.). Analiza GC-MS a uleiului esențial a demonstrat deosebiri substanțiale atât cantitative cât și calitative. Numărul componenților identificați în uleiul esențial al diferitor specii de Hypericum este diferit. În uleiul esențial separat din H. perforatum L. s-au identificați 33 componenți, β-cariofilen și cariofilen oxid în concentrații de peste 12% fiind componenții majori, urmați de α-pinen (8,574%), β-cadinen (4,155%) și β-pinen (3,216%). La H. elegans în uleiul esențial au fost identificați 18 componenți, g-gurjunen, aromadendren și undecan fiind componenții majori în concentrații de 14,532%, 13,990% și 10,262 %, respectiv. La specia H. tetrapterum s-au identificat în uleiul esențial 21 componenți, iar componenții majori sunt copaen (9,271%), α-longipinen (8,489%) urmați de cadinen (6,423%). În uleiul esențial al speciei H. hirsutum au fost identificați numai 9 componenți, concentrații mai ridicate fiind atestate la cariofilen oxid (10,435%), phytol (6,056%), α-cariofilen (5,086%) și undecan (4,279%).The Hypericum L. species from the spontaneous flora of the Republic of Moldova are distinguished by the content and composition of the essential oil produced through hydrodistillation in Ginsberg’s units from the aerial part of the plant (Hyperici herba). H. perforatum L. herba contains 0.26% (dry matter) of essential oil, H. elegans - 0.15% (dry matter), H. hirsutum - 0.094% (dry matter), and H. tetrapterum - 0.13% (dry matter). GC-MS analysis of the essential oil has demonstrated substantial differences both quantitatively and qualitatively. The number of components identified in the essential oil in different Hypericum species is different. Thirty three components were identified in the essential oil isolated from H. perforatum L., β-caryophyllene and caryophyllene oxide at concentrations above 12% being the major components followed by β-pinene (8.574%), β-cadinene (4.155%), and β-pinene (3.216%). Eighteen components were identified in the essential oil of H. elegans, g-gurjunene, aromadendrene, and undecane being the major components at concentrations of 14.532%, 13.990%, and 10.262 %, respectively. Twenty one components were identified in the essential oil of the H. tetrapterum species, copaene (9.271%) and α-longipinene (8.489%) being the major components followed by cadinene (6.423%). Nine components were identified in the essential oil of the H. hirsutum species, elevated concentrations being found in caryophyllene oxide (10.435%), phytol (6.056%), α-caryophyllene (5.086%) and undecane (4.279%)