22,787 research outputs found
Unifying metastasis--Integrating intravasation, circulation and end organ colonization
Recent technological advances that have enabled the measurement of circulating tumour cells (CTCs) in patients have spurred interest in the circulatory phase of metastasis. Techniques that do not solely rely on a blood sample allow substantial biological interrogation beyond simply counting CTCs
Diffusion and Interdiffusion in Binary Metallic Melts
We discuss the dependence of self- and interdiffusion coefficients on
temperature and composition for two prototypical binary metallic melts, Al-Ni
and Zr-Ni, in molecular-dynamics (MD) computer simulations and the
mode-coupling theory of the glass transition (MCT). Dynamical processes that
are mainly entropic in origin slow down mass transport (as expressed through
self diffusion) in the mixture as compared to the ideal-mixing contribution.
Interdiffusion of chemical species is a competition of slow kinetic modes with
a strong thermodynamic driving force that is caused by non-entropic
interactions. The combination of both dynamic and thermodynamic effects causes
qualitative differences in the concentration dependence of self-diffusion and
interdiffusion coefficients. At high temperatures, the thermodynamic
enhancement of interdiffusion prevails, while at low temperatures, kinetic
effects dominate the concentration dependence, rationalized within MCT as the
approach to its ideal-glass transition temperature . The Darken equation
relating self- and interdiffusion qualitatively reproduces the
concentration-dependence in both Zr-Ni and Al-Ni, but quantitatively, the
kinetic contributions to interdiffusion can be slower than the lower bound
suggested by the Darken equation. As temperature is decreased, the agreement
with Darken's equation improves, due to a strong coupling of all kinetic modes
that is a generic feature predicted by MCT.Comment: 16 pages, 12 figure
Spiral Growth and Step Edge Barriers
The growth of spiral mounds containing a screw dislocation is compared to the
growth of wedding cakes by two-dimensional nucleation. Using phase field
simulations and homoepitaxial growth experiments on the Pt(111) surface we show
that both structures attain the same characteristic large scale shape when a
significant step edge barrier suppresses interlayer transport. The higher
vertical growth rate observed for the spiral mounds on Pt(111) reflects the
different incorporation mechanisms for atoms in the top region and can be
formally represented by an enhanced apparent step edge barrier.Comment: 11 pages, 4 figures, partly in colo
Tight local approximation results for max-min linear programs
In a bipartite max-min LP, we are given a bipartite graph \myG = (V \cup I
\cup K, E), where each agent is adjacent to exactly one constraint
and exactly one objective . Each agent controls a
variable . For each we have a nonnegative linear constraint on
the variables of adjacent agents. For each we have a nonnegative
linear objective function of the variables of adjacent agents. The task is to
maximise the minimum of the objective functions. We study local algorithms
where each agent must choose based on input within its
constant-radius neighbourhood in \myG. We show that for every
there exists a local algorithm achieving the approximation ratio . We also show that this result is the best possible
-- no local algorithm can achieve the approximation ratio . Here is the maximum degree of a vertex , and
is the maximum degree of a vertex . As a methodological
contribution, we introduce the technique of graph unfolding for the design of
local approximation algorithms.Comment: 16 page
Gaia Stellar Kinematics in the Head of the Orion A Cloud: Runaway Stellar Groups and Gravitational Infall
This work extends previous kinematic studies of young stars in the Head of
the Orion A cloud (OMC-1/2/3/4/5). It is based on large samples of infrared,
optical, and X-ray selected pre-main sequence stars with reliable radial
velocities and Gaia-derived parallaxes and proper motions. Stellar kinematic
groups are identified assuming they mimic the motion of their parental gas.
Several groups are found to have peculiar kinematics: the NGC 1977 cluster and
two stellar groups in the Extended Orion Nebula (EON) cavity are caught in the
act of departing their birthplaces. The abnormal motion of NGC 1977 may have
been caused by a global hierarchical cloud collapse, feedback by massive Ori
OB1ab stars, supersonic turbulence, cloud-cloud collision, and/or slingshot
effect; the former two models are favored by us. EON groups might have
inherited anomalous motions of their parental cloudlets due to small-scale
`rocket effects' from nearby OB stars. We also identify sparse stellar groups
to the east and west of Orion A that are drifting from the central region,
possibly a slowly expanding halo of the Orion Nebula Cluster. We confirm
previously reported findings of varying line-of-sight distances to different
parts of the cloud's Head with associated differences in gas velocity.
Three-dimensional movies of star kinematics show contraction of the groups of
stars in OMC-1 and global contraction of OMC-123 stars. Overall, the Head of
Orion A region exhibits complex motions consistent with theoretical models
involving hierarchical gravitational collapse in (possibly turbulent) clouds
with OB stellar feedback.Comment: Accepted for publication in MNRAS. 26 pages, 13 figures. The two 3-D
stellar kinematic movies, aimed as Supplementary Materials, can be found on
YouTube at: https://youtu.be/B4GHCVvCYfo (`restricted' sample) and
https://youtu.be/6fUu8sP0QFI (`full' sample
Polarization-controlled single photons
Vacuum-stimulated Raman transitions are driven between two magnetic substates
of a rubidium-87 atom strongly coupled to an optical cavity. A magnetic field
lifts the degeneracy of these states, and the atom is alternately exposed to
laser pulses of two different frequencies. This produces a stream of single
photons with alternating circular polarization in a predetermined
spatio-temporal mode. MHz repetition rates are possible as no recycling of the
atom between photon generations is required. Photon indistinguishability is
tested by time-resolved two-photon interference.Comment: 4 pages, 3 figure
Electroweak Sudakov Logarithms and Real Gauge-Boson Radiation in the TeV Region
Electroweak radiative corrections give rise to large negative,
double-logarithmically enhanced corrections in the TeV region. These are partly
compensated by real radiation and, moreover, affected by selecting
isospin-noninvariant external states. We investigate the impact of real gauge
boson radiation more quantitatively by considering different restricted final
state configurations. We consider successively a massive abelian gauge theory,
a spontaneously broken SU(2) theory and the electroweak Standard Model. We find
that details of the choice of the phase space cuts, in particular whether a
fraction of collinear and soft radiation is included, have a strong impact on
the relative amount of real and virtual corrections.Comment: 20 pages, 4 figure
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