199 research outputs found
"Jetzt weiß ich, dass ich weder verrückt bin noch sterben werde!" : Die Verhaltenstherapie-Ambulanz verbindet Forschung, Lehre und Praxis
Psychische Störungen überschreiten alle Grenzen – es gibt sie in allen Kulturen, zu allen Zeiten, in allen soziodemografischen Schichten und in jedem Lebensalter. Sie sind häufige Themen sowohl in Talkshows, Fernsehserien und Illustrierten als auch in Literatur, Theater und bildender Kunst. Jeden können sie treffen, und beinahe jeder kennt zumindest eine Person, die an einer klinisch bedeutsamen psychischen Störung leidet. Zu deren Behandlung und Erforschung sowie zur Ausbildung von Psychologischen Psychotherapeuten wurde 1999 am Fachbereich Psychologie und Sportwissenschaften der Universität Frankfurt die Verhaltenstherapie-Ambulanz eingerichtet. Primäres Ziel der universitären Ambulanz ist dabei, die Forschung und Lehre des Fachs »Klinische Psychologie und Psychotherapie « mit der praktischen therapeutischen Arbeit an Klienten zusammenzuführen, um damit die Verbindung aus Forschung, Lehre, Ausbildung und Praxis herzustellen
Über Religionsunterricht und Religionsfreiheit: ein Briefwechsel per E-Mail
Aus einer Rückmeldung zum vorstehenden reli.-Grundsatzbeitrag entstand ein längerer Briefwechsel per E-Mail, in dem Fragen zu einem zukunftstauglichen schulischen Religionsunterricht diskutiert werden. Der Austausch liegt hier in gekürzter Fassung vor
Localization of cyanobacterial photosystem II donor-side subunits by electron microscopy and the supramolecular organization of photosystem II in the thylakoid membrane
Localization of cyanobacterial photosystem II donor-side subunits by electron microscopy and the supramolecular organization of photosystem II in the thylakoid membrane
Localization of cyanobacterial photosystem II donor-side subunits by electron microscopy and the supramolecular organization of photosystem II in the thylakoid membrane
A large set of electron microscopy projections of photosystem II (PSII) dimers isolated from the cyanobacterium Synechococcus elongatus was characterized by single particle image analysis. In addition to previously published maps at lower resolution [Boekema, E.J., Hankamer, B., Bald, D., Kruip, J., Nield, J., Boonstra, A.F., Barber, J. & Rogner, M. (1995) Proc. Natl Acad. Sci. USA 92, 175-179], the new side-view projections show densities of all three lumenal extrinsic proteins, i.e. the 33-kDa, 12-kDa and the cytochrome c-550 subunit encoded by psbO, psbU and psbV, respectively. Analysis of the size and shape of the top-view projections revealed a small number of photosystem II particles of about double the size of the usual dimers. Size and quantity of these 'double dimers' correlates with a small fraction of 1000-kDa particles found with HPLC-size-exclusion chromatographic analysis. Because many cyanobacteria contain dimeric photosystem II complexes arranged in rows within the membrane, the double dimers can be considered as the breakdown fragments of these rows. Their analysis enabled the detection of the arrangement of photosystem II within the rows, in which the dimers interact with other dimers mostly with their tips, leaving a rather open center at the interfaces of two dimers. The dimers have a repeating distance of only 11.7 nm. As a consequence, the phycobilisomes, located on Lop of PSII and functioning in light-harvesting, must be closely packed or almost touch each other, in a manner similar to a recently suggested model [Bald, D., Kruip, J. & Rogner, M.(1996) Photosynthesis Res. 49, 103-118].</p
834-2 Clonal T-cell composition is not associated with enteroviral or adenoviral infection in dilated cardiomyopathy: Implications for the pathogenesis of dilated cardiomyopathy
A Finely Segmented Semi-Monolithic Detector tailored for High Resolution PET
Preclinical research and organ-dedicated applications require high-resolution
positron emission tomography (PET) detectors to visualize small structures and
understand biological processes at a finer level of detail. Current commercial
systems often employ finely pixelated or monolithic scintillators, each with
its limitations. We present a semi-monolithic detector, tailored for
high-resolution PET applications, and merging concepts of monolithic and
pixelated crystals. The detector features slabs measuring (24 x 10 x 1) sq. mm,
coupled to a 12 x 12 readout channel photosensor with 4 mm pitch. The slabs are
grouped in two arrays of 44 slabs each to achieve a higher optical photon
density. We employ a fan beam collimator for fast calibration to train
machine-learning-based positioning models for all three dimensions, including
slab identification and depth-of-interaction (DOI), utilizing gradient tree
boosting (GTB). Energy calculation was based on a position-dependent energy
calibration. Using an analytical timing calibration, time skews were corrected
for coincidence timing resolution (CTR) estimation. Leveraging
machine-learning-based calibration in all three dimensions, we achieved high
detector spatial resolution: down to 1.18 mm full width at half maximum (FWHM)
detector spatial resolution and 0.75 mm mean absolute error (MAE) in the
planar-monolithic direction along the slabs, and 2.14 mm FWHM and 1.03 mm MAE
for depth-of-interaction (DOI) at an energy window of (435-585) keV. Correct
slab interaction identification exceeded 80%, alongside an energy resolution of
13.8% and a CTR of 450 ps FWHM. Therewith, the introduced finely segmented,
high-resolution slab detector demonstrates an appealing performance suitable
for high-resolution PET applications. The current benchtop-based detector
calibration routine allows these detectors to be used in PET systems.Comment: 14 pages, 11 figures, IEEE NSS MIC RTSD 202
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