Клинико-статистический анализ предикторов летальных исходов у больных туберкулезом, получающих лечение в учреждениях ФСИН России

The objective: to determine risk factors of lethal outcomes (predictors) in tuberculosis patients treated with chemotherapy regimens I, II, III during confinement in the Russian penitentiary system.Subjects and Methods: data on 6,069 patients registered for treatment in 2019 and 2020 were studied. Univariate and multivariate analyses were performed.Results. The following factors were found to have effect on mortality: age (aOR = 1.05; 95% CI 1.03-1.06), multiple localizations of tuberculosis (aOR = 11.08; 95% CI 5.12-24.20), concurrent HIV infection (aOR = 9.13; 95% CI 6.90-12.24), and positive sputum microscopy at registration (aOR = 5.18; 95% CI 3.93-6.81). The patient gender was found to have no effect (OR = 0.9; 95% CI 0.4-1.9; p = 1).Цель исследования: определить факторы риска летального исхода (предикторы) у пациентов с туберкулезом, получающих лечение по I, II, III режимам химиотерапии во время нахождения в пенитенциарных учреждениях России.Материалы и методы: изучены сведения о 6 069 записях о пациентах, зарегистрированных для лечения в 2019 и 2020 г. Проводили одномерный и многомерный анализ.Результаты. Установлено влияние на частоту летального исхода возраста (aOR = 1,05; 95% CI 1,03-1,06), множественных локализаций туберкулеза (aOR = 11,08; 95% CI 5,12-24,20), наличия сопутствующей ВИЧ-инфекции (aOR = 9,13; 95% CI 6,90-12,24), положительного результата микроскопии мокроты при регистрации (aOR = 5,18; 95% CI 3,93-6,81). Не было выявлено влияния пола пациентов (OR = 0,9; 95% CI 0,4-1,9; p = 1)

Influence of high-intensity CO2 laser irradiation on collagen matrix composition of normotrophic skin scars (experimental study)

The experiment was carried out in 25 laboratory rats. After modeling of normotrophic cutaneous scars, the procedure of laser dermabrasion with 50 Watt carbon dioxide laser was performed in superpulse mode with impulse-pause ratio of 0,5:100 ms and 500 µm spot diameter. Morphological, immunohistochemical and morphometric examination of skin histological sections were performed. A single exposure to CO2 laser radiation in this mode resulted in the early formation of mainly type III collagen and then type I collagen in ratios approaching to the intact skin.Проведено экспериментальное исследование на 25-ти лабораторных крысах, которым после моделирования нормотрофических кожных рубцов выполняли процедуру лазерной дермабразии излучением углекислого лазера мощностью 50 Вт в суперимпульсном режиме с соотношением импульс – пауза 0,5:100 мс и диаметром пятна 0,5 мм. Проводили морфологическое, иммуногистохимическое морфометрическое исследование гистологических срезов кожи. Установлено, что однократное воздействие излучением Со2 лазера в указанных режимах приводит к образованию в ранние сроки преимущественно коллагена III типа, а затем и коллагена I типа в соотношениях, приближающихся к показателям интактной кожи

Derivatives of phosphorus acids and α-chloroallyl alcohol - Communication 2. Synthesis of mixed α-chloroallyl esters of phosphoric acid and some of their biological properties

1. A series of derivatives of phosphorus acids and α-chloroallyl alcohol was obtained. 2. Increasing the length of the hydrocarbon radical attached to the phosphorus atom from C1 to C6 leads to a sharp increase in the selectivity of the action of the compounds toward Trichophyton gypseum and Epidermophyton Kaufmann-Wolf. A further increase in the length of the radical decreases the anti-fungal activity of the compounds. 3. It was established that di-n-amyl α-chloroallyl phosphate has the highest selectivity index of action toward dermatophytes. © 1972 Consultants Bureau

Derivatives of phosphorus acids and α-chloroallyl alcohol - Communication 2. Synthesis of mixed α-chloroallyl esters of phosphoric acid and some of their biological properties

1. A series of derivatives of phosphorus acids and α-chloroallyl alcohol was obtained. 2. Increasing the length of the hydrocarbon radical attached to the phosphorus atom from C1 to C6 leads to a sharp increase in the selectivity of the action of the compounds toward Trichophyton gypseum and Epidermophyton Kaufmann-Wolf. A further increase in the length of the radical decreases the anti-fungal activity of the compounds. 3. It was established that di-n-amyl α-chloroallyl phosphate has the highest selectivity index of action toward dermatophytes. © 1972 Consultants Bureau

Le Courrier des spectacles, ou Journal des théâtres

17 octobre 18041804/10/17 (N2789)