The ecological domain in the sustainability science research and education

A single disciplinary approach fails to tackle problems threatening the sustainable development. Thus, the sustainability  science – focused on the problem, normative, and covering many disciplines – has been developed and recognized as critical in  creating solutions that could actually trigger a global change. As an example, environmental issues are no longer the problem to be  solved within the ecological domain but the primary and complex sources of the problem must be analysed from the social, economic  and technical perspectives as well, using methodological tools allowing for a variety of disciplines. This study provides a systematic  review of publications related to sustainability and ecology, and briefly explains the role of environmental knowledge in the sustainability  education. The study has shown that despite a common scepticism about combining qualitative and quantitative approaches the  employment of miscellaneous disciplines has become a common approach and ecology in the context of sustainability goes beyond  the ecological research. It appears from the reviewed curriculum of the sustainability science graduate programme at the University  of Tokyo that environmental knowledge is well established, but is generally driven by transdisciplinary courses. It was included in  the half of credits from compulsory courses, whereas elective courses are those which are open to other disciplines.

インターロイキン-1β暴露下のラットの血管におけるエタノールによる誘導型一酸化窒素合成酵素抑制を介した弛緩反応の抑制

Nitric oxide produced by inducible nitric oxide synthase (iNOS) regulates sepsis-induced hypotension. During septic shock, interleukin (IL)-1β is synthesized in endothelial cells and smooth muscle cells by endotoxin. Ethanol (EtOH) suppresses endotoxin-induced hypotension. The present study aimed to elucidate the effect of EtOH on gradual relaxation and iNOS expression induced by IL-1β in isolated rat superior mesenteric arteries (SMAs). Exposure to IL-1β–induced contraction in SMA rings, followed by a gradual relaxation of phenylephrine precontracted tone. Contraction was abolished by indomethacin (IM), cycloheximide (Chx), and endothelium denudation. In contrast, the gradual relaxation was abolished by NOS inhibitors, Chx, endothelium denudation, and inhibited by EtOH (50 and 100 mM). However, IM had no effect on relaxation. Western blot analysis demonstrated that iNOS expression was induced by IL-1β and was inhibited by EtOH and endothelium denudation. Furthermore, messenger RNA expression of iNOS, but not endothelial NOS, was inhibited by EtOH. These data suggest that IL-1β–induced contraction is mediated by thromboxane A2, whereas IL-1β–induced relaxation occurs via NO derived from iNOS. The endothelium plays an important role in vasorelaxation. Taken together, EtOH inhibits IL-1β–mediated vasorelaxation by suppressing endothelium iNOS expression. This study provides the first evidence of EtOH -induced inhibition of IL-1β–mediated vasorelaxation.博士（医学）・甲第647号・平成28年3月15日© The Author(s)Copyright © 2016 by SAGE PublicationsThe definitive version is available at " http://dx.doi.org/10.1177/0960327115611944

Fostering the Next Generation of Sustainability Professionals – Assessing Field-based Courses in a Sustainability Science Graduate Program

A growing number of educational programs in sustainability science has paralleled the rise of the field itself. The educational approach of these programs follows the problem-driven, interdisciplinary, and transdisciplinary nature of the field itself. However, its effectiveness has yet to be systematically evaluated. Similarly, while ad-hoc evaluation schemes have attempted to monitor the quality of the educational programs, there is no standard method that accounts for the particularities of sustainability science programs. This study thus addresses the need for an assessment of the problem-driven approach of educational programs in sustainability science. We have conducted student self-assessments of field courses in the Graduate Program in Sustainability Science (GPSS-GLI) at The University of Tokyo, which positions its field courses at the center of its curriculum. The self-assessments were based on five key competencies identified as particularly important for sustainability professionals. Workshops and questionnaires engaged students in a reflection of the six field courses and of their own personal development through the activities offered. Our questionnaire results indicate that the majority of participants were satisfied with how the courses furthered their personal development. While some participants expressed frustration at being unable to sufficiently address the respective field's sustainability challenges due to time constraints, students generally recognized the five key competencies as important for addressing sustainability issues after participating in the courses. Moreover, participants attributed much of their learning to their active engagement in planned field research activities, rather than to passive learning. Variations in results across different course units provide material for further analysis and development of the curriculum. This study is an initial attempt at assessment, with room for ongoing improvement and further research to address additional requirements for fostering the next generation of sustainability professionals

Fostering the Next Generation of Sustainability Professionals - Assessing Field-based Courses in a Sustainability Science Graduate Program

A growing number of educational programs in sustainability science has paralleled the rise of the field itself. The educational approach of these programs follows the problem-driven, interdisciplinary, and transdisciplinary nature of the field itself. However, its effectiveness has yet to be systematically evaluated. Similarly, while ad-hoc evaluation schemes have attempted to monitor the quality of the educational programs, there is no standard method that accounts for the particularities of sustainability science programs. This study thus addresses the need for an assessment of the problem-driven approach of educational programs in sustainability science. We have conducted student self-assessments of field courses in the Graduate Program in Sustainability Science (GPSS-GLI) at The University of Tokyo, which positions its field courses at the center of its curriculum. The self-assessments were based on five key competencies identified as particularly important for sustainability professionals. Workshops and questionnaires engaged students in a reflection of the six field courses and of their own personal development through the activities offered. Our questionnaire results indicate that the majority of participants were satisfied with how the courses furthered their personal development. While some participants expressed frustration at being unable to sufficiently address the respective field's sustainability challenges due to time constraints, students generally recognized the five key competencies as important for addressing sustainability issues after participating in the courses. Moreover, participants attributed much of their learning to their active engagement in planned field research activities, rather than to passive learning. Variations in results across different course units provide material for further analysis and development of the curriculum. This study is an initial attempt at assessment, with room for ongoing improvement and further research to address additional requirements for fostering the next generation of sustainability professionals

An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2

BACKGROUND: Aryl hydrocarbon receptor (AhR) not only regulates drug-metabolizing enzyme expression but also regulates cancer malignancy. The steps to the development of malignancy include angiogenesis that is induced by tumor microenvironments, hypoxia, and nutrient deprivation. Vascular endothelial growth factor (VEGF) plays a central role in the angiogenesis of cancer cells, and it is induced by activating transcription factor 4 (ATF4). RESULTS: Recently, we identified that glucose deprivation induces AhR translocation into the nucleus and increases CYP1A1 and 1A2 expression in HepG2 cells. Here, we report that the AhR pathway induces VEGF expression in human hepatoblastoma HepG2 cells under glucose deprivation, which involves ATF4. ATF4 knockdown suppressed VEGF expression under glucose deprivation. Moreover, AhR knockdown suppressed VEGF and ATF4 expression under glucose deprivation at genetic and protein levels. CONCLUSIONS: The AhR-VEGF pathway through ATF4 is a novel pathway in glucose-deprived liver cancer cells that is related to the microenvironment within a cancer tissue affecting liver cancer malignancy

Entrusting the Future of Rural Society through Nurturing Civic Pride: Endeavors in Gojome Town, Akita Prefecture of Japan

This photo essay illustrates a study on endeavors in a rural Japanese town with a declining population and discusses the future of rural society from a perspective of civic pride as well as sustainability. The population of the town of Gojome, located in Akita Prefecture of northern Japan, has halved from 20,025 in 1960 to 9,481 in 2015. Depopulation is often perceived as a half-empty glass, but we approached our study with the view that it is half-full. We discuss the issue through appreciative approaches by adopting the concept of “civic pride” as an alternative lens based on our empirical survey. The methodology adopted for this field survey include individual interviews with 126 respondents (consisting of 79 residents of Gojome and 47 individuals who were visiting the town) across different generations, 15 key informant interviews, drawings of their pride about the town by 34 sixth-graders of Gojome Elementary School, and observations. It was found that various generations of proud Gojome locals and non-locals have started to proactively participate in the process of bettering the town through various social, cultural, economic, and environmental activities. Based on our learning in Gojome town we conclude that, in the wake of rural depopulation, nurturing “civic pride” could potentially contribute to rural sustainability through entrusting the future of rural society to next generations

高齢社会における農村地域の サステイナビリティ

学位の種別: 課程博士審査委員会委員 : (主査)東京大学特任教授 長尾 眞文, 東京大学教授 味埜 俊, 東京大学教授 山路 永司, 東京大学准教授 小貫 元治, 東京大学特任准教授 鎗目 雅, 東京大学准教授 村山 顕人University of Tokyo(東京大学

Identifying Context-Specific Categories for Visualizing Livability of Cities—a Case Study of Malmö

Livability is a concept being applied to cities, even though it is vague. Worldwide, there are several livable city ranking schemes in use, which compare the livability of cities by making use of standardized indicator sets. The research presented here recognizes, as a point of departure, that each city is unique, implying that comparisons of cities by standardized categories only does not adequately reflect the reality of each city. A qualitative approach to identify context-specific categories of livability is proposed and employed to the case of Malmo ̈ in Sweden. Through interviews, nine context-specific categories were identified and visualized. The findings of the study demonstrate that a qualitative approach enables a more in-depth description of livability categories because it can capture and illustrate relationships among the categories. An explicit awareness of such relationships may provide a more holistic perspective to city officials and planners as they aim to improve the livability of their cities. The study concludes that a qualitative approach in identifying context-specific categories can complement existing assessment schemes and allow a better grasp of livability challenges to cities

Multiplex PCRを用いた簡便で感度の高い溺死診断法の開発

For diagnosing death due to drowning, the method of acid digestion of diatoms is widely used to detect plankton in the organs of the corpse. However, the method is limited by its　being complex, hazardous, time-consuming, and insufficiently sensitive. We therefore, developed a novel simple method to diagnose death due to drowning, and determined the location of drowning by detecting genes of representative bacteria in the environment. To procure all the information in one step, the multiplex PCR method was designed. For the diagnosis of drowning, the genes of upper respiratory indigenous bacteria, Streptococcus salivarius and Streptococcus sanguinis were used as indicators. For detection of the location of drowning, Aeromonas hydrophila and Microcystis aeruginosa were used as indicators of freshwater, and Vibrio harveyi as an indicator of seawater. A set of primers was designed for multiplex PCR. to amplify all the bacterial genes simultaneously. Using this method, 47 cases of drowning were examined, and the causes and locations of death were diagnosed.博士（医学）・乙第1428号・平成31年3月15