Rare case of huge rectal and uterovaginal prol

A case of combined genital prolapse and rectal prolapse in a 60-year-old multipara is reported. The treatment of mixed prolapse remains surgical and should be treated the genital prolapse by vaginal hysterectomy with pelvic floor repair and the rectal prolapse by means of the Delorme operation. The mortality and morbidity rates are zero if this operation is used and the relapse rate is only 8 to 11% for the rectal prolapse. It would appear that the two approaches are rarely associated by the authors and would seem to be interesting to reconsider this question by indicating mixed treatment of the two prolapses whenever possible

Comparative study of programmed labor and traditional management of labor

Background: Prolongation of labor leads to dehydration, ketoacidosis, infection, fetal asphyxia. Programmed labor aims at reducing the duration of labor, labor pain and incidence of cesarean section with improved maternal and neonatal outcome.Aims and Objectives:1)       To evaluate the effect of programmed labor on duration of labor.2)       To assess efficacy of analgesics in reducing pain of labor.3)       To find out maternal and neonatal complications.4)       To study impact of programmed labor on LSCS rates.Methods: Prospective randomized study of primigravida in active labor (after 4 cm cervical dilatation) for which 100 women were selected for programmed labor (cases) and 100 women were selected for traditional management of labor (controls). Cases were subjected to interventions to improve uterine contractions (ARM, Dinoprostone tablets, and Oxytocin drip), to facilitate cervical dilatation (Inj. Drotaverine), to relieve labor pains (Inj. Pentazocine & Diazepam). All labors were monitored by partogram.Results: Programmed labor reduced duration of first and second stage of labor. There was faster cervical dilatation (1.8 cm/hour against 1.2 cm/hour). Majority of the patients had better pain relief. There was no impact on LSCS ratesConclusions: Programmed labor significantly reduced duration of labor with good pain relief without compromising maternal and fetal/neonatal safety. But it had no impact on LSCS rates

Aggressive angiomyxoma of broad ligament: an uncommon mesenchymal tumor

Aggressive angiomyxoma is a rare mesenchymal tumor occurring predominantly in the pelviperineal region. Authors present a case of a 70 years female presented with history of distention of lower abdomen with recurrent pain since 6 months. On clinical examination there was suspicion of fibroid. On USG it was reported as huge fleshy, soft tissue mass measuring 20x10x9 cm in lower abdominal flanks and pelvis with vascular pedicle attached to right parametrium. Pan-hysterectomy was performed. Right broad ligament showed mass measuring 18.5x10x6 cm. On histopathological examination it was diagnosed as a case of Aggressive angiomyxoma of broad ligament. We are presenting this case for its extreme rarity, clinicohisto-pathological and radiological findings

Study of prevalence and determinants of polycystic ovarian syndrome among adolescent girls in rural area: a prospective study

Background: Polycystic ovarian syndrome (PCOS) is the most frequent endocrinological disorder affecting 5-10% of women in the reproductive age. This prevalence ranging from 2.2% to 26% in adult women from 18-45 year. In a recent study the prevalence of a confirmed diagnosis of PCOS in adolescents aged 10 to 19 years was 5-15%, which increased to 10-22%. When undiagnosed cases with documented symptoms qualifying for PCOS according to NIH (National institute of Health) criteria were included. PCOS is a complex endocrine disorder which is most common in women of reproductive age. PCOS may first present in adolescence, but the incidence of PCOS in adolescence is not known, as diagnostic criteria for PCOS in the adolescent age-group is still not defined, PCOS symptoms tend to overlap with normal pubertal changes making the diagnosis even more challenging. The objective is to study prevalence and symptomatology of polycystic ovary syndrome (PCOS) in adolescent girls.Methods: Prospective Cross sectional study between April 2018 and March 2019. 150 adolescent girls aged 10 to 19 years attending OPD with oligomenorrhea, irregular menstrual cycle, obesity and/or hirsutism were advised for biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS on the basis of Rotterdam's criteria at the Department of Obstetrics and Gynaecology, Krishna Institute of Medical Sciences, Deemed University, Karad, Maharashtra, India.Results: Prevalence of PCOS in the study was 17.33% in the study group.Conclusions: PCOS is increasingly encountered during adolescence, although the overall prevalence is low and evaluation of PCOS in adolescents is challenging. At this age, lifestyle modification is imperative to prevent long-term metabolic and reproductive complications

Uterine Lipoleiomyoma: a rare variant of benign uterine neoplasm

The lipomatous tumors are very rare benign neoplasms of the uterus. Lipoleiomyoma is a benign tumor which is variant of leiomyoma. It has similar clinical course and presentation like uterine leiomyoma and is typically found in postmenopausal women. Authors report a case of 45 years female presented with a complaint of increased frequency of menstrual cycles and generalized weakness since 5- 6 months. On ultrasonography abdomen - pelvis a single large lobulated hyperechoic mass was noted in the fundal myometrium measuring 5 x 4.6 cm. The finding was suggestive of fibroid uterus. On histopathological examination showed variable proportions of lobules of mature adipocytes and interlacing bundles of benign smooth muscle cells which was diagnostic of lipoleiomyoma. Authors are presenting this case for its rarity, clinical presentation, imaging and histopathological finding with differential diagnosis

Ovarian teratomas: clinicopathological study at tertiary care center

Background: Teratomas are belonging to a group of germ cell tumors. It is also referred to as dermoid cyst. Teratomas are most common germ cell tumor of the ovary. Teratomas are composed of various histological types. In this article we are presenting various morphological patterns, its clinical manifestation and its clinical significance.Methods: This is prospective study for a period of 3 years from March 2016 to February 2019 at tertiary care hospital. It consists of total evaluation of 82 cases of ovarian lesions which were surgically excised for clinically or radiologically suspected of ovarian neoplasm.Results: A total of 82 cases of ovarian specimen were included out of which 18 cases were of ovarian teratoma. In these 17 cases were benign teratomas, 1 case of immature teratoma. All the cases of mature teratoma were predominantly of cystic type with focal solid areas. Right sided ovary was involved in44.5% cases while left sided in 55.5% cases. The tumor size ranges from 2.5 cm to 20.8 cms. The age range in this study was from 20 to 60 year. The common age observed for ovarian teratoma was in group of 31-40 years, having 6 cases. The clinically most of cases were asymptomatic or presented with unexplained abdominal pain or palpable mass. USG finding in most of cases were diffuse or partial echogenic mass lesion with cystic nature and echogenic bands.Conclusions: In our study showed mature cystic teratoma is the most common type of ovarian teratomas. The immature and monodermal types are rare. The histopathological examination plays important role in final diagnosis   and patient management

Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach using captopril (CP) and hydrochlorothiazide (HCTZ) as a model drug. Captopril being unstable in intestinal pH and HCTZ has specific absorption from duodenum and the first part of the jejunum and to a small extent in the stomach are suitable candidate for GRDDS. 32 factorial design was employed in formulating and optimizing the GRDDS for bilayer tablet of CP and HCTZ matrix tablet. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The gastroretentive ability of the tablets was evaluated by X-radiographic studies in healthy human volunteer. The tablet releases CP and HCTZ for extended period up to 24 h in controlled manner. The predicted values agreed well with the experimental values and the results demonstrate the feasibility of the optimization methodology in the development of GRDDS. The tablet was buoyant for up to 16 h in human stomach. Development of once a day gastroretentive formulation of CP and HCTZ improves the patience compliance and bioavailability of drugs.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach using captopril (CP) and hydrochlorothiazide (HCTZ) as a model drug. Captopril being unstable in intestinal pH and HCTZ has specific absorption from duodenum and the first part of the jejunum and to a small extent in the stomach are suitable candidate for GRDDS. 32 factorial design was employed in formulating and optimizing the GRDDS for bilayer tablet of CP and HCTZ matrix tablet. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The gastroretentive ability of the tablets was evaluated by X-radiographic studies in healthy human volunteer. The tablet releases CP and HCTZ for extended period up to 24 h in controlled manner. The predicted values agreed well with the experimental values and the results demonstrate the feasibility of the optimization methodology in the development of GRDDS. The tablet was buoyant for up to 16 h in human stomach. Development of once a day gastroretentive formulation of CP and HCTZ improves the patience compliance and bioavailability of drugs.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach using captopril (CP) and hydrochlorothiazide (HCTZ) as a model drug. Captopril being unstable in intestinal pH and HCTZ has specific absorption from duodenum and the first part of the jejunum and to a small extent in the stomach are suitable candidate for GRDDS. 32 factorial design was employed in formulating and optimizing the GRDDS for bilayer tablet of CP and HCTZ matrix tablet. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The gastroretentive ability of the tablets was evaluated by X-radiographic studies in healthy human volunteer. The tablet releases CP and HCTZ for extended period up to 24 h in controlled manner. The predicted values agreed well with the experimental values and the results demonstrate the feasibility of the optimization methodology in the development of GRDDS. The tablet was buoyant for up to 16 h in human stomach. Development of once a day gastroretentive formulation of CP and HCTZ improves the patience compliance and bioavailability of drugs.Colegio de Farmacéuticos de la Provincia de Buenos Aire