5 research outputs found
Stanowisko Komitetu Terapii i Nauk o Leku PAN (KTiNoL PAN), Komitetu Nauk Fizjologicznych i Farmakologicznych PAN (KNFiF), Polskiego Towarzystwa Farmakologicznego (PTF), Polskiego Towarzystwa Farmakologii Klinicznej i Terapii (PTFKiT), Polskiego Towarzystwa Nadciśnienia Tętniczego (PTNT) oraz Sekcji Farmakoterapii Sercowo-Naczyniowej Polskiego Towarzystwa Kardiologicznego (SFSN PTK) dotyczące chlorochiny w leczeniu zakażenia SARS-CoV-2 powodującego COVID-19
Get PDFPosition paper of Scientific Committees of the Polish Academy of Sciences (Committee on Therapy and Drug Research, Committee on Physiology and Pharmacology) and Polish scientific societies (Polish Society of Pharmacology, Polish Society of Clinical Pharma
Get PDFCationic derivative of dextran reverses anticoagulant activity of unfractionated heparin in animal models of arterial and venous thrombosis
No full textNew arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal
No full textNew derivatives of polyallylamine containing arginine moieties (PAH-ARG) were synthesized. The in vitro tests performed in heparinized blood plasma showed that the complexation of heparin by PAH-ARG polymers allowed the reduction of the activated partial thromboplastin time (aPTT) values to the normal level. The dose of PAH-ARG required for complete reversal of aPTT (prolonged by 1 U of heparin) was half of that required for protamine sulfate, the currently used heparin antagonist. The efficacy of these polymers in the neutralization of heparin was confirmed by in vivo tests using a rat model. PAH-ARG polymers were nontoxic to the fibroblast cells
