Successful Non-Invasive treatment of stricturing fibrosing colonopathy in an adult patient

<p>Abstract</p> <p>Objective</p> <p>Fibrosing colonopathy (FC) is a rare entity associated with cystic fibrosis (CF). Until now, patients with stricturing FC have usually been treated surgically. In this instance, we aimed at avoiding surgery by applying a new conservative approach.</p> <p>Methods</p> <p>Case report on an adult with CF who developed persistent abdominal pain due to a non-passable stricture in the right transverse colon. Histology confirmed fibrosing colonopathy.</p> <p>Results</p> <p>Initially we treated the patient with prednisolone pulse therapy and additive antibiotic therapy. For maintenance therapy we administered budesonide. The patient underwent clinical, laboratory and endoscopic follow-up over a three-year period. The stricture healed and was easy to pass. A relapse in the cecum at the ileocecal valve again improved under steroid and antibiotic therapy.</p> <p>Conclusions</p> <p>We present a novel therapeutic approach for advanced stricturing FC in an adult patient which successfully avoided surgery (right hemicolectomy) over a three year follow up.</p

Incomplete Dissociation in Solutions of Strong Electrolytes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70904/2/JCPSA6-9-3-283-1.pd

Hidden order in bosonic gases confined in one dimensional optical lattices

We analyze the effective Hamiltonian arising from a suitable power series expansion of the overlap integrals of Wannier functions for confined bosonic atoms in a 1d optical lattice. For certain constraints between the coupling constants, we construct an explicit relation between such an effective bosonic Hamiltonian and the integrable spin-$S$ anisotropic Heisenberg model. Therefore the former results to be integrable by construction. The field theory is governed by an anisotropic non linear $\sigma$-model with singlet and triplet massive excitations; such a result holds also in the generic non-integrable cases. The criticality of the bosonic system is investigated. The schematic phase diagram is drawn. Our study is shedding light on the hidden symmetry of the Haldane type for one dimensional bosons.Comment: 5 pages; 1 eps figure. Revised version, to be published in New. J. Phy

Estudios preliminares para la determinación de la resistencia a cortadura interlaminar ST mediante los ensayos Iosipescu y "Short beam shear"

La resistencia a cortadura interlaminar ST es una característica del material que juega un papel significativo en algunos de los criterios de fallo de la matriz en compresión con más repercusión en la actualidad (e.g.: Hashin, Puck, "World Wide Failure Exercise", 1998, 2002). Sin embargo, dicha característica resulta difícil de medir experimentalmente, por lo que es común la aproximación de dicho valor a partir de otras características del material que resultan más simples de determinar (resistencia a cortadura intralaminar S, resistencia a compresión perpendicular a las fibras YC, resistencia a cortadura en el ensayo "Short Beam Shear", SBS). En este trabajo se realiza un estudio acerca de la posibilidad de medir la resistencia a cortadura interlaminar ST empleando una configuración modificada de la probeta Iosipescu, y mediante una variante del ensayo SBS con las fibras perpendiculares a la dirección longitudinal de la probeta. Los resultados obtenidos para las diferentes configuraciones, y para distintas dimensiones de las probetas son analizados en el presente estudio.Ministerio de Ciencia y Tecnología MAT2000-111

Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial

Background: Adequate bowel preparation is essential for accurate colonoscopy. Both oral sodium phosphate (NaP) and polyethylene glycol-based lavage (PEG-ELS) are used predominantly as bowel cleansing modalities. NaP has gained popularity due to low drinking volume and lower costs. The purpose of this randomized multicenter observer blinded study was to compare three groups of cleansing (NaP, NaP + sennosides, PEG-ELS + sennosides) in reference to tolerability, acceptance, and cleanliness. Patient and Methods: 355 outpatients between 18 and 75 years were randomized into three groups (A, B, C) receiving NaP = A, NaP, and sennosides = B or PEG-ELS and sennosides = C. Gastroenterologists performing colonoscopies were blinded to the type of preparation. All patients documented tolerance and adverse events. Vital signs, premedication, completeness, discomfort, and complications were recorded. A quality score (0–4) of cleanliness was generated. Results: The three groups were similar with regard to age, sex, BMI, indication for colonoscopy, and comorbidity. Drinking volumes (L) (A = 4.33 + 1.2, B = 4.56 + 1.18, C = 4.93 + 1.71) were in favor of NaP (P = .005). Discomfort from ingested fluid was recorded in A = 39.8% (versus C: P = .015), B = 46.6% (versus C: P = .147), and C = 54.6%. Differences in tolerability and acceptance between the three groups were statistically not significant. No differences in adverse events and the cleanliness effects occurred in the three groups (P = .113). The cleanliness quality scores 0–2 were calculated in A: 77.7%, B: 86.7%, and C: 85.2%. Conclusions: These data fail to demonstrate significant differences in tolerability, acceptance, and preparation quality between the three types of bowel preparation for colonoscopy. Cleansing with NaP was not superior to PEG-ELS

Exact results on the Kitaev model on a hexagonal lattice: spin states, string and brane correlators, and anyonic excitations

In this work, we illustrate how a Jordan-Wigner transformation combined with symmetry considerations enables a direct solution of Kitaev's model on the honeycomb lattice. We (i) express the p-wave type fermionic ground states of this system in terms of the original spins, (ii) adduce that symmetry alone dictates the existence of string and planar brane type correlators and their composites, (iii) compute the value of such non-local correlators by employing the Jordan-Wigner transformation, (iv) affirm that the spectrum is inconsequential to the existence of topological quantum order and that such information is encoded in the states themselves, and (v) express the anyonic character of the excitations in this system and the local symmetries that it harbors in terms of fermions.Comment: 14 pages, 7 figure

Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial

A list of investigators of the International Salofalk OD Study Group is given in the appendix. Investigators from Latvia are: Jelena Derova, Aleksejs Derovs, Juris Pokrotnieks, Aldis Pukitis, Mairita Ergle.Objectives: To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. Design: A randomised, double-blind, double-dummy, parallel group, multicentre, international, phase III noninferiority study. Setting: 54 centres in 13 countries. Patients: 380 patients with confirmed diagnosis of established or first attack of ulcerative colitis (clinical activity index (CAI)>4 and endoscopic index ≥ 4 at baseline) were randomised and treated. Interventions: 8-week treatment with either 3 g OD or 1 g TID mesalazine granules. Main outcome measures: Clinical remission (CAI ≤ 4) at study end. Results: 380 patients were evaluable for efficacy and safety by intention-to-treat (ITT); 345 for per protocol (PP) analysis. In the ITT population, 79.1% in the OD group (n = 191) and 75.7% in the TID group (n = 189) achieved clinical remission (p<0.0001 for non-inferiority). Significantly more patients with proctosigmoiditis achieved clinical remission in the OD group (86%; n = 97) versus the TID group (73%; n = 100; p = 0.0298). About 70% of patients in both treatment groups achieved endoscopic remission, and 35% in the OD group and 41% in the TID group achieved histological remission. About 80% of all patients preferred OD dosing. Similar numbers of adverse events occurred in 55 patients (28.8%) in the OD group and in 61 patients (32.3%) in the TID group, indicating that the two dosing regimens were equally safe and well tolerated. Conclusions: OD 3 g mesalazine granules are as effective and safe as a TID 1 g schedule. With respect to the best possible adherence of patients to the treatment, OD dosing of mesalazine should be the preferred application mode in active ulcerative colitis. ClinicalTrials.gov Identifier: NCT00449722.publishersversionPeer reviewe

Use of complementary and alternative medicine in Germany – a survey of patients with inflammatory bowel disease

BACKGROUND: Previous studies have suggested an increasing use of complementary and alternative medicine (CAM) in patients with inflammatory bowel disease (IBD). The aim of our study was to evaluate the use of CAM in German patients with IBD. METHODS: A questionnaire was offered to IBD patients participating in patient workshops which were organized by a self-help association, the German Crohn's and Colitis Association. The self-administered questionnaire included demographic and disease-related data as well as items analysing the extent of CAM use and satisfaction with CAM treatment. Seven commonly used CAM methods were predetermined on the questionnaire. RESULTS: 413 questionnaires were completed and included in the analysis (n = 153 male, n = 260 female; n = 246 Crohn's disease, n = 164 ulcerative colitis). 52 % of the patients reported CAM use in the present or past. In detail, homeopathy (55%), probiotics (43%), classical naturopathy (38%), Boswellia serrata extracts (36%) and acupuncture/Traditional Chinese Medicine (TCM) (33%) were the most frequently used CAM methods. Patients using probiotics, acupuncture and Boswellia serrata extracts (incense) reported more positive therapeutic effects than others. Within the statistical analysis no significant predictors for CAM use were found. 77% of the patients felt insufficiently informed about CAM. CONCLUSION: The use of CAM in IBD patients is very common in Germany, although a large proportion of patients felt that information about CAM is not sufficient. However, to provide an evidence-based approach more research in this field is desperately needed. Therefore, physicians should increasingly inform IBD patients about benefits and limitations of CAM treatment