2 research outputs found
Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure.
- Author
- Publication venue
- Jefferson Digital Commons
- Publication date
- 27/01/2019
- Field of study
Hepatitis B virus (HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma (HCC). During the last two decades, with the use of currently available anti-HBV therapies (lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBV-associated HCC (HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA (cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure (loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV
Angeborene Herz- und Gefäßfehler
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- LG Druepple
- LG Rigler
- LH Garland
- LH Kettler
- LH Meeker
- LJ Boyd
- LJ Boyd
- LJ Manhoff Jr.
- LJ Ross
- LM Becu
- LM Becu
- LM Becu
- LM Blackford
- LM Blackford
- LM Bonnet
- LM Linde
- LP Elliott
- LR Limon
- LS Blumenthal
- LS Gordon
- LT Bullock
- LT Wald Le
- M Abbott
- M Anderson
- M Borst
- M Brombart
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Cleveland
- M Cohen
- M Dahm
- M Dubois
- M Durand
- M Durand
- M Durand
- M Fogal
- M Franke
- M Friedmann
- M Goldbloom
- M Grob
- M Grob
- M Grob
- M Grob
- M Grob
- M Halipre
- M Herbst
- M Holzmann
- M Honey
- M Jequier
- M Kahn
- M Kartagener
- M Kühne
- M Langeron
- M Lev
- M Lev
- M Lev
- M Lillian
- M Lingen van
- M Lipson
- M Lubert
- M Löweneck
- M MacLeod
- M Mandelstamm
- M Mouquin
- M Nagel
- M Roch
- M Segers
- M Segers
- M Segers
- M Sewart
- M Silvestrini
- M Sossai
- M Stahlmann
- M Ursini
- M Vizcaino
- M Wahl
- M Watson
- M Weinbren
- MA Chiechi
- MA Dollfus
- MA Engle
- MA Engle
- MA Engle
- MA Kugel
- MB Ariel
- MB Copleman
- MC Achard
- MC McCord
- MCF Lindert
- McKinley
- MD Altschle
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- Meckel
- MF Joly
- MF Moses
- MF Steinberg
- MF Steinberg
- MF Steinberg
- MG Austin
- MG Desai
- MG Stevens
- MH Uhley
- MH Wittenborg
- MH Wittenborg
- MJ Askey
- MJ Carson
- MJ Hubeny
- MJ Reeh
- MJ Shapiro
- MK Ledbetter
- ML Carnes
- ML Susman
- ML Young
- MM Figley
- MM Glendy
- MR Drennan
- MV Cruz De La
- MV Pfaundler
- MW Arthurron
- N Coulshed
- N Kusnetzowsky
- N Oeconomos
- N Schad
- N Schad
- N Schad
- N Tanner-Cain
- NA Halasz
- NB Everett
- NE Freeman
- NE Reich
- NF Trench
- NG Demy
- NR Barrett
- NR Konar
- NS Donavan
- NS Talner
- NW Philpott
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Fraentzel
- O Garcia
- O Heitzmann
- O Hueck
- O Krausse
- O Müller
- O Petersen
- O Saphir
- O Schleckat
- O Storstein
- O Storstein
- O Wenner
- Oberwinter
- OC Brantigan
- OC Railsback
- OH Wangenstein
- OR Morgan
- OS Tubbs
- OW Husebye
- O’Bryan
- P Adams
- P Adams
- P Amundsen
- P Batchelder
- P Belou
- P Broustet
- P Cachen
- P Calazel
- P Charrague
- P Chiche
- P Corone
- P Cossio
- P Delthil
- P Fleming
- P Formijne
- P Galle
- P Geipel
- P Gellert
- P Huard
- P Kezdi
- P Krepler
- P Laurens
- P Merklen
- P Mouren
- P Quintin
- P Samet
- P Schölmerich
- P SouliÉ
- P SouliÉ
- P Soulié
- P Soulié
- P Soulié
- P Soulié
- P Stumpf
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Vernaut
- P Weischer
- P Wood
- P Wood
- P Wood
- P Zagorsky
- P ödman
- P ödman
- P ödmann
- PA Herbut
- PBN Odgers
- PD White
- PE Kaunitz
- PE Linebach
- PH Davison
- PH Futcher
- Ph Uyttenhove
- PI Halonen
- PJD Snow
- PM Ayrolles
- PN Yu
- PO Issajew
- PR Slade
- PW Gebauer
- PW Speschilow
- R Adams
- R Ash
- R Bilger
- R Brock
- R Bulgarelli
- R Debré
- R Fono
- R Gelfman
- R Gürtler
- R Hagen
- R Hanna
- R Heim De Balsac
- R Heim de Balsac
- R Heim De Balsac
- R Heim De Balsac
- R Heim de Balsac
- R Heim De Balsac
- R Heim de Balsac
- R Janker
- R Janker
- R Janker
- R Janker
- R Janker
- R Kilby
- R Kunzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Limon Lason
- R Lutembacher
- R Mohr
- R Nicks
- R Paltauf
- R Pannier
- R Pape
- R Pavlitzek
- R Potts
- R Praagh van
- R Quain
- R Quain
- R Rippert
- R Rippert
- R Robertson
- R Rössle
- R Schatzki
- R Schmaltz
- R Shaw
- R Stintzing
- R Thoma
- R Vernejoul De
- R Wenger
- R Wilson
- R Zenker
- R Zuckermann
- RA Bruce
- RA Deterling Jr.
- RA Deterling Jr.
- RA Deterling Jr.
- RA Furman
- RA Lyon
- RA Miller
- RA Sprengel
- RA Stebbins
- RB Blacket
- RB Disenhouse
- RC Anderson
- RC Anderson
- RC Anderson
- RC Anderson
- RC Brock
- RC Darling
- RC Scott
- RC Scott
- RD Lockhart
- RD Powell
- RD Smith
- RE Gross
- RE Gross
- RE Gross
- RE Gross
- RE Gross
- RE Johnson
- RE Steen
- RF Grover
- RF Grover
- RF Grover
- RF Healey
- RF Shaner
- RF Shaner
- RF Shaner
- RF Ziegler
- RG Hebb
- RG McGorkle
- RG Palmer
- RG Siekert
- RH Balsac
- RH Goetz
- RH Goetz
- RH Murray
- RH Sweet
- RI Lloyd
- RIG Sinclair
- RJ Bing
- RJ Bing
- RJ Bing
- RJ Bing
- RJ Marvel
- RK Piper
- RL Riley
- RM Marquis
- RM Norman
- RM Stewart
- RN Astley
- RN Cooley
- RN Paul
- RO Brandenburg
- RO Brigham
- RP Allen
- RP Grant
- RP Grant
- RP Johnson
- RS Cosby
- RS Cosby
- RS Fontana
- RS Fontana
- RW Alexander
- RW Baer
- RW Collett
- RW Collett
- RW Dickson
- RW Scott
- RX Zittel
- S Bellet
- S Berber
- S Bleifer
- S Buchs
- S Buchs
- S Cheu
- S Contro
- S Dack
- S Eek
- S Effert
- S Effert
- S Farber
- S Gibson
- S Gibson
- S Gibson
- S Gibson
- S Gordon
- S Howard
- S Howath
- S Kejlson
- S Mackler
- S McGinn
- S McLean
- S Millman
- S Novelo
- S Oram
- S Sailer
- S Sailer
- S Sanes
- S Scheef
- S Schorr
- S Seiler
- S Skapinker
- S Uchida
- S Wilkes
- SA Levine
- SC Blount
- SC Mitchell
- SC Shattock
- SE Courter
- SE Gould
- SE Gould
- SE Gould
- SG Blount
- SG Blount
- SG Blount
- SG Blount Jr.
- SG Blount Jr.
- SG Shepherd
- SGr Blount
- SH Marder
- SI Seldinger
- SJ Powell
- SL Burwell
- SO Wasastjerna
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Levine
- SRF Whittacker
- SS Lichtman
- St Mahrburg
- ST Sömmering
- St Zacharioudakis
- SW Hunter
- Symington
- Symptomatische Pulmonalstenose
- T Fisher
- T Lewis
- T Munkner
- T Peacock
- TB Peacock
- TB Peacock
- TF Hilbish
- TF Hubbard
- Th Bothwell
- TH Burford
- Th Cowie
- Th Hornykiewitsch
- TI Dry
- TJ Dry
- TM Welsh
- TO Dorrance
- TW Griffith
- TW Griffith
- TY Dry
- UI Roche
- V Beato Nunez
- V Eisenmenger
- V Eskelund
- V Malacarne
- V Moragues
- V Moragues
- V Rubio
- V Salle
- V Schilling
- V Sprenkel
- V Thaden
- VA McKusick
- VA McKusick
- Varco
- VB Dolgopol
- VB Dolgopol
- VG Brekke
- VL Gott
- VO Björk
- VO Björk
- W Bircks
- W Bridgen
- W Coulson
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Dressler
- W Evans
- W Evans
- W Ewald
- W Falholt
- W Gerok
- W Gerok
- W Graf
- W Gruber
- W Haggenmiller
- W Harvey
- W Heck
- W Heek
- W Herzog
- W Hickman
- W Jegier
- W Krause
- W Müller
- W Porstmann
- W Porstmann
- W Porstmann
- W Risel
- W Roessler
- W Schulze
- W Schweizer
- W Siegenthaler
- W SipilÄ
- W Smull
- W Teschendorf
- W Turner
- W Weitz
- W Whitaker
- W Whitaker
- W Zinn
- WA Wimsatt
- WB Bean
- WB Civin
- WB Porter
- WC Schraft
- WCD Richards
- WD Hurst
- WE Medd
- Weiss-Eder
- WF Bugden
- WF Doolittle
- WF Kraemer
- WF Weaver
- WF Windle
- WG Gunteroth
- WG McCallum
- WG Mitchell
- WG Smith
- WH Muller
- WH Muller
- WH Pritchard
- WH Welch
- WI Potts
- Wieting
- Winslow
- WJ Atwell
- WJ Brown
- WJ Elliot
- WJ Muller Jr.
- WJ Patterson
- WJ Porter
- WJ Potts
- WJ Potts
- WK Purks
- WL Riker
- WM Yater
- WP Cleland
- WP Herringham
- WPO Hwang
- WR Livesay
- WS Church
- WS Conklin
- WS Greenfield
- WS Hastings
- WS Love Jr.
- WS Tinney
- WS Tinney Jr.
- WS Tinney Jr.
- WT Mustard
- WT Mustard
- WT Mustard
- WT Mustard
- WW Beattie
- WW Fray
- WW Herrmann
- WW Meyer
- WW Wagstaffe
- Y Larsson
- YS Palladino
- Z Belobradek
- — Die Mißbildungen des menschlichen Herzens. Ergebn. allg. Path. path
- —La double crosse aortique
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1967
- Field of study