5-bromo- and 5-iodo-N-1-sulfonylated cytosine derivatives. Exclusive formation of keto-imino tautomers

N-1-Sulfonylated cytosine 5 and 5-halogeno-N-1-sulfonylated cytosine derivatives 1 and 2 were synthesized by condensation of silylated cytosine or 5-halogenocytosine bases with tosylchloride in acetonitrile, or by the reaction of cytosine or 5-halogenocytosine bases with tosylchloride in pyridine. The NMR evidences are presented, showing that 1 and 2 form exclusively rare keto-imino tautomers in DMSO-d(6) solution, while N-1-sulfonylated cytosine 5 appears as a common keto-amino tautomer

5-Bromo- and 5–Iodo-N-1-sulfonylated Cytosine Derivatives. Exclusive Formation of Keto-Imino Tautomers

N-1-Sulfonylated cytosine 5 and 5-halogeno-N-1-sulfonylated cytosine derivatives 1 and 2 were synthesized by condensation of silylated cytosine or 5-halogenocytosine bases with tosylchloride in acetonitrile, or by the reaction of cytosine or 5-halogenocytosine bases with tosylchloride in pyridine. The NMR evidences are presented, showing that 1 and 2 form exclusively rare keto-imino tautomers in DMSO-d6 solution, while N-1-sulfonylated cytosine 5 appears as a common keto-amino tautomer

Synthesis, NMR and MS Study of Novel N-Sulfonylated Purine Derivatives

Tosylation and mesylation of adenine (1) at room temperature give regioselectively N9-sulfonylated purines 2 and 5. Excess of TsCl or MsCl at higher reaction temperatures leads to formation of unstable N6,N9-disulfonylated products 3 and 6, which easily transform into the corresponding N9-monosulfonylated product 4. Two N-sulfonylated purine nucleoside derivatives 12 and 15 have also been prepared. 1D/2D NMR determined the site of sulfonylation and the spatial arrangement of the substituents. MS spectra showed unexpected rearrangement of protonated molecular ions that occurs upon the loss of SO2

Who is the better candidate? Macroinvertebrates and diatoms for ecological status assessment of Sava Lake (Serbia)

Sava Lake was created from the right arm of the Sava River, and the inhabitants of Belgrade use the lake intensively for swimming and bathing. We analysed macrozoobenthos and epilithic diatom communities at six sites from April to October 2017, to assess the ecological status of Sava Lake according to the National legislation of Serbia. Considering macrozoobenthos communities, the mean values of Zelinka and Marvan saprobity index indicated high ecological status. In contrast, results obtained from the mean values of BMWP (Biological Monitoring Working Party) scores suggested moderate to poor ecological status. The mean values of the IPS diatom index (Indice de Polluo-sensibilité) indicated high ecological status, while the TDIL index (Trophic Diatom Index for lakes) was slightly more sensitive and indicated good ecological status. Water chemical parameters indicated that Sava Lake was mainly oligotrophic during the study period (average total phosphorus concentrations were 10.7 μgL-1 and average total nitrogen concentrations 410 μgL-1). Before being able to adopt an integrative approach for ecological status assessment (combining two or more biological quality elements), more studies must be performed on how to choose the most sensitive and adequate indices. This is especially true for lakes experiencing intensive anthropogenic pressure during the summer season. Also, the boundary values in the National legislation of Serbia must be adapted for lakes, such as Sava Lake.11th Symposium for European Freshwater Sciences, June 30–July 5, 2019, Zagreb, Croatia, [http://www.sefs11.biol.pmf.hr/

Prilozi povijesti psihologije u Hrvatskoj

Prilozi povijesti hrvatske psihologije prvo je referentno djelo s povijesnim pregledom hrvatske psihologije. Poglavlja donose pregršt vrijednih informacija o psiholozima i njihovim aktivnostima koje su omogućile da se psihologija u Hrvatskoj razvije u respekatbilnu znanost i struku. Autori priloga, redom istaknuti sveučilišni profesori i praktičari, i sami su dio povijesti psihologije u Republici Hrvatskoj. U knjizi opisuju prva istraživanja, početke sveučilišnog obrazovanja, primjenu znanja u praksi te sistematiziraju razvoj temeljnih i primijenjenih grana psihologije kroz razdoblja, autore i znanstvene teme. Sustavno su prikazana sva važna područja psihologije. Stoga ovo djelo predstavlja značajan znanstveni doprinos proučavanju povijesti psihologije u Hrvatskoj. (Iz recenzija prof.dr.sc Darja Maslić Seršić, prof. dr.sc Dražen Domijan

Prilozi povijesti psihologije u Hrvatskoj

Prilozi povijesti hrvatske psihologije prvo je referentno djelo s povijesnim pregledom hrvatske psihologije. Poglavlja donose pregršt vrijednih informacija o psiholozima i njihovim aktivnostima koje su omogućile da se psihologija u Hrvatskoj razvije u respekatbilnu znanost i struku. Autori priloga, redom istaknuti sveučilišni profesori i praktičari, i sami su dio povijesti psihologije u Republici Hrvatskoj. U knjizi opisuju prva istraživanja, početke sveučilišnog obrazovanja, primjenu znanja u praksi te sistematiziraju razvoj temeljnih i primijenjenih grana psihologije kroz razdoblja, autore i znanstvene teme. Sustavno su prikazana sva važna područja psihologije. Stoga ovo djelo predstavlja značajan znanstveni doprinos proučavanju povijesti psihologije u Hrvatskoj. (Iz recenzija prof.dr.sc Darja Maslić Seršić, prof. dr.sc Dražen Domijan

Testing the applicability of diatom indices for ecological assessment of Balkan lakes

During 2016-2017 six Balkan lakes were investigated: Sava Lake in Serbia, Ohrid Lake and Prespa Lake in North Macedonia and Albania, Great Lake in Albania, Biogradsko Lake and Crno Lake in Montenegro. Epilithic diatom samples were collected from 6 localities around each lake with the aim to test the applicability of diatom indices for ecological assessment of Balkan lakes. Also, water samples for chemical analysis were taken. Based on the concentrations of total phosphorus and BOD (biochemical oxygen demand) two lakes (Ohrid and Crno) were oligotrophic and oligosaprobic, while the other four lakes were mesotrophic and β-mesosaprobic, respectively. The highest diversity of dominant taxa was recorded in Ohrid and Prespa, and one of the dominant taxa was the endemic species Gomphonema paratergestinum. Diatom communities in lakes Sava and Crno were dominated by Achnanthidim minutissimum and Encyonopsis microcephala. According to Serbian legislation, the IPS index is used for the assessment of the ecological status of lakes, while in North Macedonia, Albania and Montenegro National Monitoring Systems do not yet include officially accepted diatom indices. In our results, the diatom indices IPS and IBD had the highest inclusion of diatom taxa, in some lakes almost 100%. The lowest inclusion of diatom taxa had the TDIL index. Values of IPS and IBD indices indicated very good water quality for Great Lake, Crno and Biogradsko, and good for Prespa. The water quality of Ohrid and Sava was between very good and good. Values of trophic indices (Rott TI and TDIL) indicated a very low concentration of nutrients in the Sava, Great Lake and Biogradsko, low in Ohrid and Prespa and low to the very low concentration of nutrients in Crno. The development and establishment of monitoring systems in lakes according to the requirements of the Water Framework Directive (WFD) is essential for all European countries and more comprehensive ecological investigations of Balkan lakes are necessary to be able to fulfill these demands.7th European Phycological Congress, Zagreb, Croatia, 25-30.08.201